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Autor:
Stefan Wirtz, Cornelia Symowski, Lisa Knipfer, Imke Atreya, Anja Schulz-Kuhnt, Markus F. Neurath, Vicky Greif, David Voehringer, Markus Kindermann
Publikováno v:
The Journal of Experimental Medicine
Knipfer et al. identify a critical role for the type 2–related chemokine receptor CCR8 on ILC2 functions during type 2 immune responses. CCR8 supports ILC2 survival by autocrine secretion of the ligand CCL1. The authors demonstrate that CCL1/CCR8 s
Autor:
Fanny Jaulin, David P. Sullivan, William A. Muller, Geri Kreitzer, Prarthana Dalal, David B. Sacks
Publikováno v:
The Journal of Experimental Medicine
The function of endothelial cell IQGAP1 during diapedesis requires its actin-binding domain and IQ motifs to recruit the lateral border recycling compartment. Genetic ablation of endothelial cell IQGAP1 expression in vivo causes significant disruptio
Autor:
Pedro E. Cruz, Christopher Janus, Karen A. Scott, Marshall S. Goodwin, Melanie R. Shapiro, Brenda D. Moore, Eric G. Krause, M. Zino Kuhn, Paramita Chakrabarty, Thomas B. Ladd, Andrew Judge, Yong Ran, Todd M. Brusko, Karen N. McFarland, Annette D. de Kloet, Cara L. Croft, Todd E. Golde, Benoit I. Giasson, Daniel Ryu, Yona Levites, Hunter S. Futch, Rachel L. Nosacka
Publikováno v:
The Journal of Experimental Medicine
A high-affinity monoclonal antibody (CTRND05) targeting corticotropin-releasing factor (CRF) blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent with suppression of t
Autor:
George Kannourakis, Susan N Christo, Sapna Devi, Stuart P. Berzins, Erica Wynne-Jones, Daniel G. Pellicci, William R. Heath, Thomas N. Burn, Raissa Fonseca, Simone L Park, Scott N. Mueller, Jerold Chun, Laura K. Mackay, Changwei Peng, Maximilien Evrard, Stephen C. Jameson, Yu Kato, Maleika Osman
Publikováno v:
The Journal of Experimental Medicine
S1PR5 impairs TRM cell differentiation by limiting T cell entry and promoting T cell egress from peripheral tissues. Local TGF-β signaling coordinates suppression of the T-bet–ZEB2–S1PR5 emigration axis, thus enforcing tissue residency.
Tis
Tis
Autor:
Rebecca Haffner-Krausz, Noam Kadouri, Jan Dobeš, Eirik Bratland, Golda M. Damari, Yael Goldfarb, Uku Haljasorg, Cristina Peligero-Cruz, Eystein S. Husebye, Bareket Dassa, Amund Holte Berger, Tal Givony, Bergithe E. Oftedal, Ziv Porat, Martina M. Erichsen, Ulus Atasoy, Dena Leshkowitz, Itay Zalayat, Shir Nevo, Yael Gruper, Jakub Abramson, Ayelet Avin, Adi Ulman, Yael Kuperman, Shifra Ben-Dor
Publikováno v:
Journal of Experimental Medicine. 218
The autoimmune regulator (AIRE) is essential for the establishment of central tolerance and prevention of autoimmunity. Interestingly, different AIRE mutations cause autoimmunity in either recessive or dominant-negative manners. Using engineered mous
Publikováno v:
The Journal of Cell Biology
Bosch et al. discuss the role of lipid droplets as a front-line defense in the immune system.
In the ongoing conflict between eukaryotic cells and pathogens, lipid droplets (LDs) emerge as a choke point in the battle for nutrients. While many pa
In the ongoing conflict between eukaryotic cells and pathogens, lipid droplets (LDs) emerge as a choke point in the battle for nutrients. While many pa
Autor:
Angus C. Nairn, Peng Xu, Jerry C. Chang, Eitan Wong, Wei Wang, Wenjie Luo, Michael Bamkole, Karima Bettayeb, Yue-Ming Li, Timothy Y. Huang, Lu-Lin Jiang, Marc Flajolet, Xiaopu Zhou, Huaxi Xu, Paul Greengard, Nancy Y. Ip
Publikováno v:
The Journal of Experimental Medicine
GSAP plays an important role in Alzheimer's disease, but the underlying cellular and molecular pathways remain unclear. Using unbiased multi-omics approaches, this study demonstrates that GSAP regulates lipid homeostasis in mitochondria-associated me
Publikováno v:
The Journal of Experimental Medicine
Inflammation can activate hematopoietic stem and progenitor cells (HSPCs) to proliferate and differentiate, signal the specification of HSPCs during embryonic development, and maintain adult HSPC homeostasis. Collins et al. review the role of inflamm
Autor:
Pingping Zheng, Shiming Ye, Enrico L. Digiammarino, Donghee Choi, Andrew V. Nguyen, Zoltan Dezso, Kathleen McGuire, Bryan M Rogers, Denny Nguyen, Sunantha Sethuraman, Gabriel R. Starbeck-Miller, Debra Chao, Xu Shi, Laura A. Smith, Namjin Chung, Dong Zhang, Wei Liu
Publikováno v:
The Journal of Experimental Medicine
VISTA biology has yet to be fully resolved despite much enthusiasm to define it as an immune checkpoint protein. Here, we show that VISTA antibodies can singly activate human monocytes and provide evidence that Syndecan-2 can regulate VISTA interacti
Autor:
Bo-Ruei Chen, Shingo Kajimura, David G. Schatz, Louis-Marie Charbonnier, Yinan Wang, Chun-Chin Chen, Jessica K. Tyler, Jaime de Juan-Sanz, Timothy A. Ryan, Philip Curman, Ryan M. Brecht, Catherine C. Liu, Talal A. Chatila, Ryan J. Farrell, Jakob D. Wikstrom, Barry P. Sleckman, Helen A. Beilinson
Publikováno v:
The Journal of Experimental Medicine
We show that the Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) family proteins SERCA2 and SERCA3 have redundant functions that are required for RAG gene expression and DNA breaks during V(D)J recombination. Loss of SERCA activity leads to B lymphop