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Publikováno v:
The Journal of Experimental Medicine
Silverman et al. demonstrate that complement activation features prominently in retinitis pigmentosa in close association with activated microglia. This response mediates adaptive neuroprotection for photoreceptors by facilitating a C3-CR3–dependen
Autor:
Jeffrey R. Gulcher, Nicholas A. Cilfone, Carmen J. Booth, Heino Velazquez, Nicolas Ricard, Susan E. Quaggin, Michael Simons, Rizaldy P. Scott, Thomas Chittenden, Javier L. Baylon
Publikováno v:
The Journal of Experimental Medicine
Suppression of endothelial ERK1/1 pathways results in multi-organ failure, similar to what is observed in patients treated with anti-VEGF therapies.
The mechanism of maintaining vascular endothelial identity and integrity is largely unknown. In
The mechanism of maintaining vascular endothelial identity and integrity is largely unknown. In
Autor:
Rajee Ganesan, Alex Marki, Johannes Roth, Gregory J. Golden, Konrad Buscher, Sara McArdle, David M. Smalley, Matthew Meyer, Jennifer M. Dan, Holger Winkels, Yi-Ting Yeh, Shu Chien, Zhichao Fan, Mitchell Kronenberg, Nadine Hartmann, William B. Kiosses, Victor Nizet, Jeffrey D. Esko, Ryosuke Saigusa, Klaus Ley, Jack D. Bui, Yoav Altman, Marco Orecchioni, Zbigniew Mikulski, Cristina B Lorenzini
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 218, iss 3
The Journal of experimental medicine, vol 218, iss 3
During bacterial sepsis, tethers break off from neutrophils rolling on the vessel wall, destabilizing neutrophil rolling and forming elongated neutrophil-derived structures (ENDS) in the blood circulation. ENDS are phosphatidylserine- and tetraspanin
Autor:
Stephan Ehl, Klaus Warnatz, Nora Naumann-Bartsch, Anika Erxleben, Geoffroy Andrieux, Myriam Ricarda Lorenz, Robin Kobbe, Maximilian Heeg, Melanie Boerries, Gerd Horneff, Gregor Dückers, Stefan Schönberger, Klaus Schwarz, Julian Staniek, Jan Rohr, Andreas Mackensen, Hermann Eibel, Stephen Owens, Miriam Groß, Patrick Kury, Julian Thalhammer, Marita Führer, Andreas P. Frei, Pascal Schneider, Charlotte M. Niemeyer, Catharina Schütz, Carla N. Castro, Markus G. Seidel, Maria Elena Maccari, Ilka Fuchs, Simon Völkl, Friedrich G. Kapp, Marta Rizzi, Ursula Warthorst, R Kolb, Christian Klemann, Maurizio Miano, Tomas Kalina, Sebastian Fuchs, Rolf Backofen, Petr Smisek, Dirk Holzinger, Christoph König, Carsten Speckmann, Sabine Jägle, Arif B. Ekici, Bodo Grimbacher, Bertram Bengsch, Anne Rensing-Ehl
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine, vol. 218, no. 2, pp. e20192191
The Journal of experimental medicine, vol. 218, no. 2, pp. e20192191
Maccari et al. identify a physiological population of highly proliferative CD38+CD45RA+, IL-10–producing TCRαβ+ T cells. They can be CD4+, CD8+, or double-negative and are controlled by FAS and CTLA4, while their survival is enhanced by mTOR and
Autor:
Elizabeth M. Jaffee, Joel S. Bader, Matthew Dunworth, Isaac S. Chan, Manisha Warrier, Hildur Knutsdottir, Veena Padmanaban, Juan Carlos Ramirez, Gayathri Ramakrishnan, Hao Zhang, Andrew J. Ewald
Publikováno v:
The Journal of Cell Biology
Chan et al. show that natural killer (NK) cells can be reprogrammed by breast cancer cells to promote metastasis. Reprogramming can be blocked by targeting NK cell inhibitory receptors TIGIT or KLRG1 or inhibiting DNA methyltransferases, which sugges
Autor:
Joan C. Marini, Heeseog Kang, Timothy Bhattacharyya, Wayne A. Cabral, Smita Jha, Zuoming Deng, Edward W. Cowen, Eric P. Hanson, Klaus Klaushofer, Aleksandra Ivovic, Eileen Lange, Paul Roschger, James D. Katz, Richard M. Siegel, Apratim Mitra, Nadja Fratzl-Zelman, Ryan K. Dale
Publikováno v:
The Journal of Experimental Medicine
Somatic mosaicism for MAP2K1-activating mutations causes radiographical “dripping candle wax” melorheostosis. Kang et al. report somatic mosaicism for SMAD3 mutations in bone lesions of endosteal pattern melorheostosis. The SMAD3 mutations increa
Autor:
Nikolaos G. Frangogiannis
Publikováno v:
The Journal of Experimental Medicine
TGF-β is a central mediator in the fibrotic response. This review discusses the role of TGF-β in tissue fibrosis, highlighting the mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeu
Autor:
Timothy Y. Huang, Qiuyang Zheng, Ying Du, Huaxi Xu, Zhuyi Li, Yingjun Zhao, Chuan Li, Wei Zhang, Jing Tian
Publikováno v:
The Journal of Experimental Medicine
Du et al. demonstrate that PKCδ modulates BACE1 expression and amyloidogenic amyloid precursor protein processing. Inhibition of PKCδ markedly reduces BACE1 expression, β-amyloid levels, and amyloid plaque formation and also rescues cognitive defi
Autor:
Thomas E. Willnow, Timothy Y. Huang, Eliezer Masliah, Yan Liu, Xiaoguang Li, Juan C. Piña-Crespo, Huaxi Xu, Yingjun Zhao, Bing Zhu, Elena B. Pasquale, Yu Sun, Lu-Lin Jiang
Publikováno v:
The Journal of Experimental Medicine
Huang et al. show that the Alzheimer’s disease (AD) risk factor SORLA inhibits amyloid β–induced synaptotoxicity and cognitive impairment through interacting with and subsequently inactivating EphA4. These findings provide a novel mechanism by w
Autor:
Hiroshi Mori, Hiroyuki Ohigashi, Ken Kurokawa, Satomi Matsuoka, Ko Ebata, Shuichiro Takahashi, Rina Hiramine, Tomohiro Yamakawa, Emi Yokoyama, Yoshitoshi Ogura, Tokiyoshi Ayabe, Rina Sugimoto, Takahide Ara, Tetsuya Hayashi, Kiminori Nakamura, Tomoyasu Aizawa, Reiki Ogasawara, Yuki Yokoi, Takanori Teshima, Eiko Hayase, Daigo Hashimoto, Kazuma Tomizuka, Takeshi Kondo, Clara Noizat
Publikováno v:
The Journal of Experimental Medicine
Hayase et al. show that R-Spondin1 stimulates intestinal stem cells to differentiate to Paneth cells and enhances luminal secretion of α-defensins. Administration of R-Spondin1 or recombinant α-defensin prevents dysbiosis mediated by graft-versus-h