Zobrazeno 1 - 10
of 305
pro vyhledávání: ''
Autor:
Tzu-Jing Yang, Tian-Neng Li, Rih-Sheng Huang, Max Yu-Chen Pan, Shu-Yu Lin, Steven Lin, Kuen-Phon Wu, Lily Hui-Ching Wang, Shang-Te Danny Hsu
Publikováno v:
Journal of Cell Biology. 221
Subcellular localization of the deubiquitinating enzyme BAP1 is deterministic for its tumor suppressor activity. While the monoubiquitination of BAP1 by an atypical E2/E3-conjugated enzyme UBE2O and BAP1 auto-deubiquitination are known to regulate it
Autor:
Badri Krishnan, Takaaki Yasuhara, Purva Rumde, Marcello Stanzione, Chenyue Lu, Hanjun Lee, Michael S. Lawrence, Lee Zou, Linda T. Nieman, Ioannis Sanidas, Nicholas J. Dyson
Publikováno v:
The Journal of Cell Biology
Krishnan et al. use FISH to show that specific forms of RB induce changes in the organization of euchromatin and heterochromatin domains. These changes are visible under the microscope, occur after cell cycle arrest, are separable from senescence, an
Autor:
Yuko Sato, Makio Tokunaga, Tetsuya Handa, Satoshi Uchino, Yasuyuki Ohkawa, Yuma Ito, Hiroshi Kimura
Publikováno v:
The Journal of Cell Biology
Uchino et al. have developed a genetically encoded probe to specifically detect the Ser2-phosphorylated, elongating form of RNA polymerase II in living cells. Ser2-phosphorylated RNA polymerase foci exhibit more dynamic motion than chromatin replicat
Autor:
Panagiotis Mistriotis, Petr Kalab, Kaustav Bera, Yuqi Zhang, Konstantinos Konstantopoulos, Runchen Zhao, Sean X. Sun, Nicolas A. Perez-Gonzalez, Emily Wisniewski, Jeremy Keys, Jan Lammerding, Soontorn Tuntithavornwat, Yizeng Li, Eda Erdogmus, Robert A. Law
Publikováno v:
The Journal of Cell Biology
The nucleus is a significant obstacle that impedes migration of cells through confining microenvironments. Mistriotis et al. propose a conceptual model in which confinement-induced RhoA/myosin-II activation promotes nuclear volume expansion, nuclear
Publikováno v:
The Journal of Cell Biology
Herbst et al. use a novel approach for identifying activity-dependent changes in the nuclear proteome of neurons and provide evidence that regulated degradation of the tumor suppressor protein PDCD4 is required for normal activity-dependent transcrip
Autor:
Dora Tortarolo, Guido Serini, Chiara Sandri, Donatella Valdembri, Giulia Villari, Matteo Astone, Marco Arese, Chiara Camillo, Roxana E. Oberkersch, Dafne Gays, Noemi Gioelli, Fabiana Clapero, Giulia Mana, Massimo M. Santoro, Nicola Facchinello, Luca Tamagnone
Publikováno v:
bioRxiv
Dynamic modulation of endothelial cell-to-cell and cell-to-extracellular matrix (ECM) adhesion is essential for blood vessel patterning and functioning. Yet, the molecular mechanisms involved in this process have not been completely deciphered. We id
Publikováno v:
The Journal of Cell Biology
This study presents a new accretion model for spontaneous microtubule formation. In this model, microtubules form through a multitude of pathways and sheet-like oligomeric intermediates in a process akin to crystal growth.
Microtubules are dynam
Microtubules are dynam
Autor:
Dimitrios K. Papadopoulos, Christos Samakovlis, Kassiani Skouloudaki, Pavel Tomancak, Elisabeth Knust, Dilan Khalili, Vasilios Tsarouhas, Ioannis Christodoulou
Publikováno v:
The Journal of Cell Biology
Skouloudaki, K, Christodoulou, I, Khalili, D, Tsarouhas, V, Samakovlis, C, Tomancak, P, Knust, E & Papadopoulos, D K 2019, ' Yorkie controls tube length and apical barrier integrity during airway development ', Journal of Cell Biology, vol. 218, no. 8, pp. 2762-2781 . https://doi.org/10.1083/jcb.201809121
Skouloudaki, K, Christodoulou, I, Khalili, D, Tsarouhas, V, Samakovlis, C, Tomancak, P, Knust, E & Papadopoulos, D K 2019, ' Yorkie controls tube length and apical barrier integrity during airway development ', Journal of Cell Biology, vol. 218, no. 8, pp. 2762-2781 . https://doi.org/10.1083/jcb.201809121
Skouloudaki et al. identify an alternative role of the transcriptional coactivator Yorkie (Yki) in controlling water impermeability and tube size of developing Drosophila airways. Tracheal impermeability is triggered by Yki-mediated transcriptional r
Autor:
Jean Gautier, Benjamin R. Schrank
Publikováno v:
The Journal of Cell Biology
Schrank and Gautier discuss the generation and function of nuclear domains during DNA repair with a special focus on nuclear actin polymerization.
Eukaryotic nuclei are organized into nuclear domains that unite loci sharing a common function. Th
Eukaryotic nuclei are organized into nuclear domains that unite loci sharing a common function. Th
Autor:
Fan Gao, Neeraj Kumar Singh, Qingyuan Fan, Manoshi Gayen, Riqiang Yan, Wanxia He, Xiangyou Hu, Li-Huei Tsai
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine (JEM)
Journal of Experimental Medicine (JEM)
The membrane-anchored CX3CL1 is best known to exert its signaling function through binding its receptor CX3CR1. This study demonstrates a novel function that CX3CL1 exerts. CX3CL1 is sequentially cleaved by α-, β-, and γ-secretase, and the release