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Publikováno v:
The Journal of Cell Biology
PDGFRβ translocates to the nucleus in a ligand-dependent manner tethered by TATA element–modifying factor 1 (TMF-1). Papadopoulos et al. show that PDGFRβ interacts with TMF-1 and Fer kinase in the nucleus, regulating chromatin remodeling by the S
Autor:
King, Megan C., Lusk, C. Patrick
Publikováno v:
The Journal of Cell Biology
King and Lusk preview work from Halfmann et al. that provides insight into the mechanisms that mediate the repair of nuclear envelope rupture.
Ruptures of the nuclear envelope can drive a catastrophic loss of nucleocytoplasmic compartmentalizati
Ruptures of the nuclear envelope can drive a catastrophic loss of nucleocytoplasmic compartmentalizati
Autor:
Nina Pedersen, Maria Lyngaas Torgersen, Harald Stenmark, Ling Wang, Zhi Hong, Camilla Raiborg
Publikováno v:
The Journal of Cell Biology
mTORC1 is activated by lysosome positioning and by amino acid–induced phosphatidylinositol 3-phosphate (PtdIns3P). Hong et al. show that amino acids stimulate recruitment of the PtdIns3P-binding protein FYCO1 to lysosomes and promote contacts betwe
Publikováno v:
The Journal of Cell Biology
Norton and Phillips-Cremins review the 3D architecture of the genome and discuss links between chromatin misfolding and human diseases.
Mammalian genomes are folded into unique topological structures that undergo precise spatiotemporal restructu
Mammalian genomes are folded into unique topological structures that undergo precise spatiotemporal restructu
Autor:
Margarita Schlackow, Monika Gullerova, Kaspar Burger, Shabaz Mohammed, Svenja Hester, Martin Potts
Publikováno v:
The Journal of Cell Biology
Recent work implicated human Dicer in the DNA damage response. Burger et al. show that DNA damage induces phosphorylation of Dicer and promotes DNA repair in the nucleus.
The endoribonuclease Dicer is a key component of the human RNA interferenc
The endoribonuclease Dicer is a key component of the human RNA interferenc
Autor:
Valentina Botti, Florian Richter, François McNicoll, Ilka Wittig, Kathi Zarnack, Michaela C. Steiner, Michaela Müller-McNicoll, Karla M. Neugebauer, Anfisa Solovyeva, Marius Wegener, Oliver D. Schwich, Ina Poser
Publikováno v:
The Journal of Cell Biology
SR proteins connect nuclear pre-mRNA processing to mRNA export and translation. Botti et al. develop a quantitative nucleocytoplasmic shuttling assay and show that SR proteins are differentially modified and active in differentiated and pluripotent c
Autor:
Lorna Wills, Saya H. Ebbesen, Wu Zheng, Navneet Narula, Scott Powers, Kendra S. Plafker, Lloyd C. Trotman, Tali Herzka, Brian D. Robinson, Kaitlin Watrud, Vivek Mittal, Brendon M. Stiles, Nasser K. Altorki, Carlos Stahlhut, Dawid G. Nowak, John E. Wilkinson, Abu Nasar, Raffaella Sordella, Matthias Minderer, Carlos Cordon-Cardo, Mireia Castillo-Martin, Martha E. Zeeman, Alexandra Ambrico, Muhan Chen, Victoria M.-Y. Wang, Scott M. Plafker
Publikováno v:
The Journal of Cell Biology
Reduced PTEN protein is linked to tumorigenesis. Here, Chen et al. show that the nuclear transport receptor Importin-11 separates PTEN from degradation machinery. IPO11 mutant mice exhibit PTEN degradation, lung adenocarcinoma, and prostate neoplasia
Publikováno v:
The Journal of Cell Biology
Cho, Irianto, and Discher review emerging mechanisms of nuclear mechanosensing and propose through meta-analyses of published data the universality of mechanosensing pathways.
The nucleus is linked mechanically to the extracellular matrix via mu
The nucleus is linked mechanically to the extracellular matrix via mu
Publikováno v:
The Journal of Cell Biology
Petrie et al. show that inhibiting matrix metalloproteinases during 3D tumor cell migration activates the fibroblast-associated nuclear piston mechanism of intracellular pressure generation to slow tumor cell movement.
Primary human fibroblasts
Primary human fibroblasts
Autor:
Marc Vooijs, Xicheng Mao, Jan M. van Deursen, Da Jia, Naoteru Miyata, Bart van de Sluis, Rebecca A. Faulkner, Luis Sifuentes-Dominguez, Lindsey L. Morris, Yeon Koo, Haiying Li, Ezra Burstein, Ondine Cleaver, Daniel D. Billadeau
Publikováno v:
Journal of Cell Biology, 211, 3, pp. 605-17
Journal of Cell Biology, 211, 605-17
The Journal of Cell Biology
Journal of Cell Biology, 211(3), 605-617. Rockefeller University Press
The Journal of Cell Biology, 211(3), 605-617. ROCKEFELLER UNIV PRESS
Journal of Cell Biology, 211, 605-17
The Journal of Cell Biology
Journal of Cell Biology, 211(3), 605-617. Rockefeller University Press
The Journal of Cell Biology, 211(3), 605-617. ROCKEFELLER UNIV PRESS
COMMD protein family member COMMD9 regulates the endosome to plasma membrane trafficking of Notch through a unique COMMD–CCDC22–CCDC93 (CCC) complex.
Notch family members are transmembrane receptors that mediate essential developmental progr
Notch family members are transmembrane receptors that mediate essential developmental progr