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pro vyhledávání: ''
Autor:
Badri Krishnan, Takaaki Yasuhara, Purva Rumde, Marcello Stanzione, Chenyue Lu, Hanjun Lee, Michael S. Lawrence, Lee Zou, Linda T. Nieman, Ioannis Sanidas, Nicholas J. Dyson
Publikováno v:
The Journal of Cell Biology
Krishnan et al. use FISH to show that specific forms of RB induce changes in the organization of euchromatin and heterochromatin domains. These changes are visible under the microscope, occur after cell cycle arrest, are separable from senescence, an
Autor:
Dimitrios K. Papadopoulos, Christos Samakovlis, Kassiani Skouloudaki, Pavel Tomancak, Elisabeth Knust, Dilan Khalili, Vasilios Tsarouhas, Ioannis Christodoulou
Publikováno v:
The Journal of Cell Biology
Skouloudaki, K, Christodoulou, I, Khalili, D, Tsarouhas, V, Samakovlis, C, Tomancak, P, Knust, E & Papadopoulos, D K 2019, ' Yorkie controls tube length and apical barrier integrity during airway development ', Journal of Cell Biology, vol. 218, no. 8, pp. 2762-2781 . https://doi.org/10.1083/jcb.201809121
Skouloudaki, K, Christodoulou, I, Khalili, D, Tsarouhas, V, Samakovlis, C, Tomancak, P, Knust, E & Papadopoulos, D K 2019, ' Yorkie controls tube length and apical barrier integrity during airway development ', Journal of Cell Biology, vol. 218, no. 8, pp. 2762-2781 . https://doi.org/10.1083/jcb.201809121
Skouloudaki et al. identify an alternative role of the transcriptional coactivator Yorkie (Yki) in controlling water impermeability and tube size of developing Drosophila airways. Tracheal impermeability is triggered by Yki-mediated transcriptional r
Publikováno v:
The Journal of Cell Biology
The authors describe a system for engineering proteases. They evolved SUMOEu/protease pairs that are compatible with eukaryotic protein expression and used SUMOEu-assisted affinity chromatography to identify Ubc9 as a nuclear import cargo and eIF5A a
Publikováno v:
The Journal of Cell Biology
Olenick et al. find that in hippocampal neurons, the cytoplasmic dynein activator Hook1 specifically activates retrograde transport of BDNF–TrkB-signaling endosomes but is not required for motility of other retrograde cargo, supporting a model of c
Autor:
Yun Zhao, Huixiong Xu, Min Chen, Chun Hou, Wenjia Wang, Pingping Nie, Shi Jiao, Liwei An, Zhaocai Zhou, Hui Zhang, Yang Tang, Zhifa Cao, Jingmin Guan
Publikováno v:
The Journal of Experimental Medicine
An et al. identify a novel MST4-mediated YAP inactivation signaling pathway and demonstrate that the MST4–YAP axis is required to suppress gastric tumorigenesis in vivo.
Hyperactivation of YAP has been commonly associated with tumorigenesis, a
Hyperactivation of YAP has been commonly associated with tumorigenesis, a
Autor:
Bo Zhong, Zhi-Dong Zhang, Tian-Chen Xiong, Zhen Tang, Zeng Cai, Jing Ye, Meng-Xin Zhang, Qiang Zhang
Publikováno v:
The Journal of Experimental Medicine
USP22 is a cytoplasmic and nuclear deubiquitinating enzyme. Cai et al. show that the cytoplasmic USP22 deubiquitinates and stabilizes the importin protein KPNA2 after viral infection, which promotes nuclear translocation of IRF3 and cellular antivira
Autor:
Joost H.A. Martens, Guillaume Hypolite, Guillaume Andrieu, Charlotte Smith, Melania Tesio, Denis Puthier, Eva M. Janssen-Megens, Guillaume Charbonnier, Hendrik G. Stunnenberg, Ivo Gut, Salvatore Spicuglia, Marta Gut, Mohamed Belhocine, Nicolas Boissel, Eve-Lyne Mathieu, Vahid Asnafi, Elizabeth Macintyre, Arnaud Petit, Aurore Touzart, Agata Cieslak
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (9), ⟨10.1084/jem.20192360⟩
Journal of Experimental Medicine, 2020, 217 (9), ⟨10.1084/jem.20192360⟩
Journal of Experimental Medicine, 217, 9, pp. 1-28
Journal of Experimental Medicine, 217, 1-28
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (9), ⟨10.1084/jem.20192360⟩
Journal of Experimental Medicine, 2020, 217 (9), ⟨10.1084/jem.20192360⟩
Journal of Experimental Medicine, 217, 9, pp. 1-28
Journal of Experimental Medicine, 217, 1-28
This manuscript presents a comprehensive epigenomic analysis of human thymocyte development and provides new molecular insights into the mechanism by which the TCRA enhancer is activated during thymic maturation by developmentally programmed repressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de66f73e71e66697e93213ace5c73bfa
http://hdl.handle.net/10230/45880
http://hdl.handle.net/10230/45880
Publikováno v:
The Journal of Cell Biology
PDGFRβ translocates to the nucleus in a ligand-dependent manner tethered by TATA element–modifying factor 1 (TMF-1). Papadopoulos et al. show that PDGFRβ interacts with TMF-1 and Fer kinase in the nucleus, regulating chromatin remodeling by the S
Publikováno v:
The Journal of Cell Biology
Norton and Phillips-Cremins review the 3D architecture of the genome and discuss links between chromatin misfolding and human diseases.
Mammalian genomes are folded into unique topological structures that undergo precise spatiotemporal restructu
Mammalian genomes are folded into unique topological structures that undergo precise spatiotemporal restructu
Autor:
Valentina Botti, Florian Richter, François McNicoll, Ilka Wittig, Kathi Zarnack, Michaela C. Steiner, Michaela Müller-McNicoll, Karla M. Neugebauer, Anfisa Solovyeva, Marius Wegener, Oliver D. Schwich, Ina Poser
Publikováno v:
The Journal of Cell Biology
SR proteins connect nuclear pre-mRNA processing to mRNA export and translation. Botti et al. develop a quantitative nucleocytoplasmic shuttling assay and show that SR proteins are differentially modified and active in differentiated and pluripotent c