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Autor:
Panagiotis Mistriotis, Petr Kalab, Kaustav Bera, Yuqi Zhang, Konstantinos Konstantopoulos, Runchen Zhao, Sean X. Sun, Nicolas A. Perez-Gonzalez, Emily Wisniewski, Jeremy Keys, Jan Lammerding, Soontorn Tuntithavornwat, Yizeng Li, Eda Erdogmus, Robert A. Law
Publikováno v:
The Journal of Cell Biology
The nucleus is a significant obstacle that impedes migration of cells through confining microenvironments. Mistriotis et al. propose a conceptual model in which confinement-induced RhoA/myosin-II activation promotes nuclear volume expansion, nuclear
Publikováno v:
The Journal of Cell Biology
Herbst et al. use a novel approach for identifying activity-dependent changes in the nuclear proteome of neurons and provide evidence that regulated degradation of the tumor suppressor protein PDCD4 is required for normal activity-dependent transcrip
Autor:
Dora Tortarolo, Guido Serini, Chiara Sandri, Donatella Valdembri, Giulia Villari, Matteo Astone, Marco Arese, Chiara Camillo, Roxana E. Oberkersch, Dafne Gays, Noemi Gioelli, Fabiana Clapero, Giulia Mana, Massimo M. Santoro, Nicola Facchinello, Luca Tamagnone
Publikováno v:
bioRxiv
Dynamic modulation of endothelial cell-to-cell and cell-to-extracellular matrix (ECM) adhesion is essential for blood vessel patterning and functioning. Yet, the molecular mechanisms involved in this process have not been completely deciphered. We id
Publikováno v:
The Journal of Cell Biology
This study presents a new accretion model for spontaneous microtubule formation. In this model, microtubules form through a multitude of pathways and sheet-like oligomeric intermediates in a process akin to crystal growth.
Microtubules are dynam
Microtubules are dynam
Autor:
Jean Gautier, Benjamin R. Schrank
Publikováno v:
The Journal of Cell Biology
Schrank and Gautier discuss the generation and function of nuclear domains during DNA repair with a special focus on nuclear actin polymerization.
Eukaryotic nuclei are organized into nuclear domains that unite loci sharing a common function. Th
Eukaryotic nuclei are organized into nuclear domains that unite loci sharing a common function. Th
Publikováno v:
The Journal of Cell Biology
The authors describe a system for engineering proteases. They evolved SUMOEu/protease pairs that are compatible with eukaryotic protein expression and used SUMOEu-assisted affinity chromatography to identify Ubc9 as a nuclear import cargo and eIF5A a
Publikováno v:
The Journal of Cell Biology
Maass et al. review interchromosomal interactions, which, like intrachromosomal interactions, are emerging as important regulators of genome organization and gene expression.
Nuclei require a precise three- and four-dimensional organization of D
Nuclei require a precise three- and four-dimensional organization of D
Publikováno v:
The Journal of Cell Biology
Lele et al. review sources of cellular forces on the nucleus and the structural contributors to its mechanical response.
Positioning and shaping the nucleus represents a mechanical challenge for the migrating cell because of its large size and r
Positioning and shaping the nucleus represents a mechanical challenge for the migrating cell because of its large size and r
Autor:
Hongyuan Yang, Ximing Du
Publikováno v:
The Journal of Cell Biology
Du and Yang preview new work from the Fujimoto laboratory unveiling how seipin regulates the formation of nucleoplasmic lipid droplets.
Nuclear lipid droplets (nLDs) are poorly characterized outside of the liver. In this issue, Sołtysik et al.
Nuclear lipid droplets (nLDs) are poorly characterized outside of the liver. In this issue, Sołtysik et al.
Autor:
Sheila S Teves
Publikováno v:
The Journal of Cell Biology
Teves previews work from the Blower laboratory describing the importance of RNA exclusion from chromosomes for cells to divide.
The dynamics and functional roles of chromatin-bound RNA during cell division are largely unexplored. In this issue,
The dynamics and functional roles of chromatin-bound RNA during cell division are largely unexplored. In this issue,