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Autor:
Ann-Kathrin Weier, Mirka Homrich, Stephanie Ebbinghaus, Pavel Juda, Eliška Miková, Robert Hauschild, Lili Zhang, Thomas Quast, Elvira Mass, Andreas Schlitzer, Waldemar Kolanus, Sven Burgdorf, Oliver J. Gruß, Miroslav Hons, Stefan Wieser, Eva Kiermaier
Publikováno v:
Journal of Cell Biology. 221
Centrosomes play a crucial role during immune cell interactions and initiation of the immune response. In proliferating cells, centrosome numbers are tightly controlled and generally limited to one in G1 and two prior to mitosis. Defects in regulatin
Autor:
Alba Zuidema, Paul Atherton, Maaike Kreft, Liesbeth Hoekman, Onno B. Bleijerveld, Nagarjuna Nagaraj, Nanpeng Chen, Reinhard Fässler, Arnoud Sonnenberg
Publikováno v:
Journal of Cell Biology. 221
Integrins mediate cell adhesion by connecting the extracellular matrix to the intracellular cytoskeleton and orchestrate signal transduction in response to chemical and mechanical stimuli by interacting with many cytoplasmic proteins. We used BioID t
Autor:
Daniele Campisi, Laurence Desrues, Kléouforo-Paul Dembélé, Alexandre Mutel, Renaud Parment, Pierrick Gandolfo, Hélène Castel, Fabrice Morin
Publikováno v:
Journal of Cell Biology. 221
Chemotactic migration is a fundamental cellular behavior relying on the coordinated flux of lipids and cargo proteins toward the leading edge. We found here that the core autophagy protein ATG9A plays a critical role in the chemotactic migration of s
Autor:
Jaeho Yoon, Kunio Nagashima, Jian Sun, Ira O. Daar, Ziqiu Wang, Christopher J. Westlake, Hyun-Kyung Lee, Christina Carpenter, Yoo-Seok Hwang, Moonsup Lee
Publikováno v:
The Journal of Cell Biology
Lee et al. identify Dyrk1a as a new interaction partner that phosphorylates CEP97, which in turn promotes recruitment of Plk1. The complex of CEP97–Dyrk1a–Plk1 plays a substantive role in the maturation and location of centrioles/basal bodies and
Autor:
Panagiotis Mistriotis, Petr Kalab, Kaustav Bera, Yuqi Zhang, Konstantinos Konstantopoulos, Runchen Zhao, Sean X. Sun, Nicolas A. Perez-Gonzalez, Emily Wisniewski, Jeremy Keys, Jan Lammerding, Soontorn Tuntithavornwat, Yizeng Li, Eda Erdogmus, Robert A. Law
Publikováno v:
The Journal of Cell Biology
The nucleus is a significant obstacle that impedes migration of cells through confining microenvironments. Mistriotis et al. propose a conceptual model in which confinement-induced RhoA/myosin-II activation promotes nuclear volume expansion, nuclear
Autor:
Adam W. Watson, Leilei Peng, Denise J. Roe, Julieann I. Puleo, Kathylynn Saboda, Robert Ros, Ghassan Mouneimne, Frank B. Gertler, Sara S. Parker, Mackenzie R. Roman, Kiarash Rahmani Eliato
Publikováno v:
The Journal of Cell Biology
Puleo et al. identify the Ena/VASP protein EVL as a crucial actin polymerization factor at focal adhesions, which regulates focal adhesion maturation and mechanosensing. Interestingly, they show that EVL promotes mechanically directed motility and du
Autor:
Stefan Wirtz, Cornelia Symowski, Lisa Knipfer, Imke Atreya, Anja Schulz-Kuhnt, Markus F. Neurath, Vicky Greif, David Voehringer, Markus Kindermann
Publikováno v:
The Journal of Experimental Medicine
Knipfer et al. identify a critical role for the type 2–related chemokine receptor CCR8 on ILC2 functions during type 2 immune responses. CCR8 supports ILC2 survival by autocrine secretion of the ligand CCL1. The authors demonstrate that CCL1/CCR8 s
Autor:
George Kannourakis, Susan N Christo, Sapna Devi, Stuart P. Berzins, Erica Wynne-Jones, Daniel G. Pellicci, William R. Heath, Thomas N. Burn, Raissa Fonseca, Simone L Park, Scott N. Mueller, Jerold Chun, Laura K. Mackay, Changwei Peng, Maximilien Evrard, Stephen C. Jameson, Yu Kato, Maleika Osman
Publikováno v:
The Journal of Experimental Medicine
S1PR5 impairs TRM cell differentiation by limiting T cell entry and promoting T cell egress from peripheral tissues. Local TGF-β signaling coordinates suppression of the T-bet–ZEB2–S1PR5 emigration axis, thus enforcing tissue residency.
Tis
Tis
Autor:
Daisuke Nanba, Koji Sayama, Hiroyuki Matsumura, Kyosuke Asakawa, Fujio Toki, Emi K. Nishimura, Kyoichi Matsuzaki, Hiroshi Toki, Ken Shiraishi
Publikováno v:
Journal of Cell Biology. 220
Skin regenerative capacity declines with age, but the underlying mechanisms are largely unknown. Here we demonstrate a functional link between epidermal growth factor receptor (EGFR) signaling and type XVII collagen (COL17A1) proteolysis on age-assoc
Autor:
Daniel J. Moore, Joseph H. R. Hetmanski, Stephen J. Royle, Patrick T. Caswell, Gabrielle Larocque, Méghane Sittewelle, Nicholas I. Clarke, Penelope J. La-Borde, Cansu Kuey, Beverley J. Wilson
Publikováno v:
The Journal of Cell Biology
Larocque et al. describe how tumor protein D52-like proteins associate with intracellular nanovesicles. These small transport vesicles are shown to be involved in recycling α5β1 integrins during cell migration and invasion.
Membrane traffic is
Membrane traffic is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5153a89aa5d907657aa04f52b1ab0d