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Autor:
Yilin Tai, Nicholas B. Gallo, Jia Ray Yu, Shinichi Nakamuta, Yu-Ting Yang, Chia-Lin Wang, Linda Van Aelst
Publikováno v:
The Journal of Cell Biology
Neuroblasts born postnatally in the ventricular–subventricular zone migrate long distances via the rostral migratory stream (RMS) to the olfactory bulb. Nakamuta et al. show that DOCK7 drives tangential migration of neuroblasts in the RMS by contro
Autor:
Aidan M. Fenix, Dylan T. Burnette, Giuseppe Balistreri, Pekka Lappalainen, Tommi Kotila, Lassi Paavolainen, Markku Varjosalo, Jaakko I. Lehtimäki
Publikováno v:
The Journal of Cell Biology
How nonmuscle myosin II is recruited to contractile actomyosin bundles or stress fibers and assembled into functional bipolar filaments is unclear. Lehtimäki et al. show that UNC-45a functions as a myosin chaperone that contributes to the assembly o
Autor:
M. Angeles Juanes, Richa Jaiswal, Habib Bouguenina, Ali Badache, Bruce L. Goode, Julian A. Eskin
Publikováno v:
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2017, ⟨10.1083/jcb.201702007⟩
Journal of Cell Biology, 2017, ⟨10.1083/jcb.201702007⟩
Journal of Cell Biology, Rockefeller University Press, 2017, ⟨10.1083/jcb.201702007⟩
Journal of Cell Biology, 2017, ⟨10.1083/jcb.201702007⟩
Cell motility depends on tight coordination between the microtubule (MT) and actin cytoskeletons, but the mechanisms underlying this MT–actin cross talk have remained poorly understood. Here, we show that the tumor suppressor protein adenomatous po
Autor:
Gaudenz Danuser, Yun Yu Tseng, Assaf Zaritsky, M. Angeles Rabadán, Shefali Krishna, Michael Overholtzer, Alan Hall
Publikováno v:
The Journal of Cell Biology
Effective collective cell migration depends on delicate tuning of cell motility forces and cell–cell communication. Zaritsky, Tseng, and coworkers identified differential roles for RhoA, RhoC, and their upstream activators in mediating long-range t
Autor:
Jakub M. Swiercz, Daniel Heil, Hendrik Nolte, Moritz Bünemann, Marie-Josée Santoni, Ramesh K. Krishnan, Jenny Pestel, Mario Looso, Lida Yang, Thomas Worzfeld, Stefan Offermanns, Jean-Paul Borg, Harmandeep Kaur, Tianliang Sun, Cornelius Krasel
Publikováno v:
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2017, 216 (1), pp.199-215. ⟨10.1083/jcb.201602002⟩
Journal of Cell Biology, 2017, 216 (1), pp.199-215. ⟨10.1083/jcb.201602002⟩
The Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2017, 216 (1), pp.199-215. ⟨10.1083/jcb.201602002⟩
Journal of Cell Biology, 2017, 216 (1), pp.199-215. ⟨10.1083/jcb.201602002⟩
The Journal of Cell Biology
Semaphorins are ligands for their receptors, plexins. In this study, Sun et al. show that a transmembrane semaphorin, Sema4A, transduces signals in a reverse manner to control migration of cancer and dendritic cells via the cell polarity protein Scri
Publikováno v:
The Journal of Cell Biology
Petrie et al. show that inhibiting matrix metalloproteinases during 3D tumor cell migration activates the fibroblast-associated nuclear piston mechanism of intracellular pressure generation to slow tumor cell movement.
Primary human fibroblasts
Primary human fibroblasts
Autor:
John Meinhardt, John A. Hammer, Jinsung Hong, Jason Yi, Dong Li, Jordan R. Beach, Grey P. Madison, Xufeng Wu, Sricharan Murugesan, Lin Shao, Eric Betzig
Publikováno v:
The Journal of Cell Biology
Murugesan et al. report that actomyosin arcs at the T cell synapse are formin-generated structures that directly propel T cell receptor cluster movement. The authors reveal the origin, organization, and functions of a major cytoskeletal network durin
Autor:
Hisham Ibrahim, Myron I. Cybulsky, María José Sandí, Björn Petri, Jacob Rullo, Paul Kubes, Michael Glogauer, Jose La Rose, Noah Fine, Ioannis D. Dimitriou, Jack Haitsma, Robert Rottapel
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology, 215(1), 107-119. Rockefeller University Press
Fine, N, Dimitriou, I D, Rullo, J, Sandi, M J, Petri, B, Haitsma, J, Ibrahim, H, La Rose, J, Glogauer, M, Kubes, P, Cybulsky, M & Rottapel, R 2016, ' GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation ', Journal of Cell Biology, vol. 215, no. 1, pp. 107-119 . https://doi.org/10.1083/jcb.201603109
Journal of Cell Biology, 215(1), 107-119. Rockefeller University Press
Fine, N, Dimitriou, I D, Rullo, J, Sandi, M J, Petri, B, Haitsma, J, Ibrahim, H, La Rose, J, Glogauer, M, Kubes, P, Cybulsky, M & Rottapel, R 2016, ' GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation ', Journal of Cell Biology, vol. 215, no. 1, pp. 107-119 . https://doi.org/10.1083/jcb.201603109
In their work, Fine et al. demonstrate that GEF-H1 is required for the spreading and crawling of neutrophils in response to intravascular blood flow. They uncover a novel mechanism that couples shear stress with Rho-dependent migratory behavior of ne
Autor:
Ilaria Cervellini, Ning Zhu, Nina Stöberl, Garrett Lee, Florence R. Fricker, Jorge Galino, Meike Hütte, David L.H. Bennett, Lucy A. McDermott, Giovanna Lalli
Publikováno v:
The Journal of Cell Biology
RalA and RalB are involved in cell migration and membrane dynamics. This study finds that ablation of RalGTPases impairs nerve regeneration and alters Schwann cell process formation; conversely, activation of RalGTPases enhancea Schwann cell process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a02d5ec350b311ac22f6055c8d8310
https://ora.ox.ac.uk/objects/uuid:1fe72709-a996-4b4b-94f2-b6c31464a023
https://ora.ox.ac.uk/objects/uuid:1fe72709-a996-4b4b-94f2-b6c31464a023
Autor:
Tardieux, Isabelle, Baum, Jake
Publikováno v:
The Journal of Cell Biology
The capacity to migrate is fundamental to multicellular and single-celled life. Apicomplexan parasites, an ancient protozoan clade that includes malaria parasites (Plasmodium) and Toxoplasma, achieve remarkable speeds of directional cell movement. Th