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Autor:
C. Florian Bentzinger, Danny A. Stark, Nicolas A. Dumont, Yu Xin Wang, Jérôme Frenette, Kevin Nhan, Julia von Maltzahn, Michael A. Rudnicki, D.D.W. Cornelison
Publikováno v:
The Journal of cell biology
The Journal of Cell Biology
The Journal of Cell Biology
In addition to stimulating skeletal muscle growth and repair, Wnt7a/Fzd7 signaling increases the polarity and directional migration of myogenic progenitors and improves the efficacy of muscle stem cell therapy.
Wnt7a/Fzd7 signaling stimulates sk
Wnt7a/Fzd7 signaling stimulates sk
Autor:
Hayley Davis, Abdolrahman S. Nateri, Anett Jandke, Axel Behrens, Roya Babaei-Jadidi, Mohammed Abuzinadah, Elsayed E. Ibrahim, Anas Saadeddin, Bradley Spencer-Dene, Belal A. Muhammad, Annabelle Lewis, Susan D Watson, Ningning Li, Ian Tomlinson, Ranjithmenon Muraleedharan
Publikováno v:
The Journal of Experimental Medicine
The E3 ubiquitin ligase component FBXW7 modulates homeostasis and inhibits tumorigenesis in the murine intestine.
The Fbxw7 (F-box/WD repeat–containing protein 7; also called CDC4, Sel10, Ago, and Fbw7) component of the SCF (Skp1/Cullin/F-box
The Fbxw7 (F-box/WD repeat–containing protein 7; also called CDC4, Sel10, Ago, and Fbw7) component of the SCF (Skp1/Cullin/F-box
Autor:
Christoph Klein, Vinicius Cotta-de-Almeida, Adrian J. Thrasher, Marisa A. P. Baptista, Parool Meelu, Peter Vandenberghe, Michelle A. Eston, Frederick W. Alt, Brian Seed, Scott B. Snapper, Lisa S. Westerberg, David A. Adamovich, Michael K. Rosen
Publikováno v:
The Journal of Experimental Medicine
X-linked neutropenia (XLN) is caused by activating mutations in the Wiskott-Aldrich syndrome protein (WASP) that result in aberrant autoinhibition. Although patients with XLN appear to have only defects in myeloid lineages, we hypothesized that activ
Autor:
Alan F. Horwitz, Leanna Whitmore, Miguel Vicente-Manzanares, Marcelo Lazzaron Lamers, Margaret A. Koach
Publikováno v:
The Journal of Cell Biology
We have found that MLC-dependent activation of myosin IIB in migrating cells is required to form an extended rear, which coincides with increased directional migration. Activated myosin IIB localizes prominently at the cell rear and produces large, s
Autor:
Bao Hong Lin, Dominic C.H. Ng, Cheh Peng Lim, Xinmin Cao, Valeria Poli, Tong Zhang, Guochang Huang
Publikováno v:
The Journal of Cell Biology
Stat3 is a member of the signal transducer and activator of transcription family, which is important in cytokine signaling. Gene ablation studies have revealed a requirement for Stat3 in diverse biological processes (Akira, S. 2000. Oncogene. 19: 260
Autor:
Fiona M. Watt, Salvador Aznar Benitah, Steffi Herold, Michaela Frye, Martin Eilers, Birgit Samans, Kristin M. Braun, Anneli Gebhardt, Hans-Peter Elsässer
Publikováno v:
The Journal of Cell Biology
Myc plays a key role in homeostasis of the skin. We show that Miz1, which mediates Myc repression of gene expression, is expressed in the epidermal basal layer. A large percentage of genes regulated by the Myc–Miz1 complex in keratinocytes encode p
Autor:
Nancy A. Louis, Sean P. Colgan, Donald W. Lawrence, Walter J. Bruyninckx, Douglas M. Lublin, Charles A. Parkos, Gregory L. Stahl
Publikováno v:
The Journal of Experimental Medicine
Neutrophil migration across mucosal epithelium during inflammatory episodes involves the precise orchestration of a number a cell surface molecules and signaling pathways. After successful migration to the apical epithelial surface, apically localize
Publikováno v:
The Journal of Cell Biology
p21-activated kinase 1 (PAK1) can affect cell migration (Price et al., 1998; del Pozo et al., 2000) and modulate myosin light chain kinase and LIM kinase, which are components of the cellular motility machinery (Edwards, D.C., L.C. Sanders, G.M. Boko
Autor:
Paola Spessotto, Roberto Perris, Massimo Degan, Valter Gattei, Raffaele Di Francia, Alfonso Colombatti, Francesca Rossi
Publikováno v:
The Journal of Cell Biology
Osteoclast (OC) precursors migrate to putative sites of bone resorption to form functionally active, multinucleated cells. The preOC FLG 29.1 cells, known to be capable of irreversibly differentiating into multinucleated OC-like cells, displayed seve
Autor:
Christine Roméro, Laurent Gagnoux-Palacios, Olivier Pommeret, Flavia Spirito, Maryline Allegra, Guerrino Meneguzzi, Jean-Paul Ortonne
Publikováno v:
The Journal of Cell Biology
Laminin 5 is a basement membrane component that actively promotes adhesion and migration of epithelial cells. Laminin 5 undergoes extracellular proteolysis of the gamma2 chain that removes the NH(2)-terminal short arm of the polypeptide and reduces t