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Autor:
Cowell, Alana R, Jacquemet, Guillaume, Singh, Abhimanyu K, Varela, Lorena, Nylund, Anna S, Ammon, York-Christoph, Brown, David G, Akhmanova, Anna, Ivaska, Johanna, Goult, Benjamin T, Sub Cell Biology, Celbiologie
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology, 220(9). Rockefeller University Press
Journal of Cell Biology, 220(9). Rockefeller University Press
Cowell et al. show that talin rod domain–containing protein 1 (TLNRD1), a protein with homology to the central region of the integrin regulator, talin, has retained the diverse interactions of talin R7R8 but has developed distinct functionality as
Autor:
F. Brad Johnson, Osamu Iwasaki, Andrew V. Kossenkov, Linh Le, Gretchen M. Alicea, Hideki Tanizawa, Ting-Lin B. Yang, Nail Fatkhutdinov, Benjamin G. Bitler, Ken-ichi Noma, Katherine M. Aird, Rugang Zhang
Publikováno v:
The Journal of Cell Biology
In senescence, specific genes encoding secreted factors are excluded from senescence-associated heterochromatin foci, but the mechanisms underlying this senescence-associated secretory phenotype (SASP) are unclear. Aird et al. show that the chromatin
Autor:
Paolo Bianchini, Alessandro Quattrone, Paola Bernabo, Toma Tebaldi, Cecilia Pederzolli, Lorenzo Lunelli, Robert J.C. Gilbert, Andrea Passerini, Gabriella Viero, Alberto Diaspro
Publikováno v:
The journal of cell biology (Online) 208 (2015): 581–596. doi:10.1083/jcb.201406040
info:cnr-pdr/source/autori:Viero G.; Lunelli L.; Passerini A.; Bianchini P.; Gilbert R.J.; Bernabo P.; Tebaldi T.; Diaspro A.; Pederzolli C.; Quattrone A./titolo:Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes/doi:10.1083%2Fjcb.201406040/rivista:The journal of cell biology (Online)/anno:2015/pagina_da:581/pagina_a:596/intervallo_pagine:581–596/volume:208
The Journal of Cell Biology
info:cnr-pdr/source/autori:Viero G.; Lunelli L.; Passerini A.; Bianchini P.; Gilbert R.J.; Bernabo P.; Tebaldi T.; Diaspro A.; Pederzolli C.; Quattrone A./titolo:Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes/doi:10.1083%2Fjcb.201406040/rivista:The journal of cell biology (Online)/anno:2015/pagina_da:581/pagina_a:596/intervallo_pagine:581–596/volume:208
The Journal of Cell Biology
Recurrent supra-ribosomal building blocks separated by ribosome-free mRNA regions form polysomes and reflect cellular translational activity.
Translation is increasingly recognized as a central control layer of gene expression in eukaryotic cell
Translation is increasingly recognized as a central control layer of gene expression in eukaryotic cell
Autor:
Victor J. Thannickal, Edward Abraham, Naftali Kaminski, Yanping Yang, Jadranka Milosevic, Gang Liu, Qiang Ding, Arnaud Friggeri
Publikováno v:
The Journal of Experimental Medicine
Uncontrolled extracellular matrix production by fibroblasts in response to tissue injury contributes to fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), a progressive and ultimately fatal process that currently has no cure. Although dy
Publikováno v:
The Journal of Cell Biology
Silencing mediator for retinoic acid and thyroid hormone receptor (SMRT) is a transcriptional corepressor that participates in diverse signaling pathways and human diseases. However, regulation of SMRT stability remains largely unexplored. We show th
Autor:
Sarah L. Dallas, C. Adrian Shuttleworth, Stuart A. Cain, Amanda Morgan, Shazia S. Chaudhry, Cay M. Kielty
Publikováno v:
The Journal of Cell Biology
We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) beta1, a powerful cytokine that modulates cell survival and phenotype. Altered TGFbeta signaling is a ma
Autor:
Romaine Stalder, Rafael Correa, Ralph M. Steinman, Vincent Piguet, Marjorie Pion, Angela Granelli-Piperno, Bastien Mangeat
Publikováno v:
The Journal of Experimental Medicine
HIV-1 infects immature dendritic cells (iDCs), but infection is inefficient compared with activated CD4+ T cells and only involves a small subset of iDCs. We analyzed whether this could be attributed to specific cellular restrictions during the viral
Autor:
Yukako Oda, Kazutoshi Mori, Tetsuya Okada, Randal J. Kaufman, Hiderou Yoshida, Kazuhiro Nagata
Publikováno v:
The Journal of Cell Biology
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. Components of both productive folding and ER-associated degradation (ERAD) mechanisms are known to be up-reg
Publikováno v:
The Journal of Cell Biology
Mutations in the gene encoding SP-C (surfactant protein C; SFTPC) have been linked to interstitial lung disease (ILD) in children and adults. Expression of the index mutation, SP-C(Deltaexon4), in transiently transfected cells and type II cells of tr
Autor:
Jochen Buck, Kenneth C. Hess, Jeanne Farrell, David R Huron, Margarita Kamenetsky, Jonathan H. Zippin, Lonny R. Levin, Donald A. Fischman
Publikováno v:
The Journal of Cell Biology
Bicarbonate-responsive “soluble” adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of