Zobrazeno 1 - 10
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Autor:
He Ren, Jihui Hao, Xiuchao Wang, Hongwei Wang, Weiwei Bai, Chongbiao Huang, Wenna Jiang, Wenwen Yu, Bo Yang, Jing Liu, Shengyu Yang, Kaili Zhao, Danqi Fu, Tai Qin, Tianxing Zhou, Wei Tan, Xin Li, Tiansuo Zhao, Song Gao
Publikováno v:
The Journal of Experimental Medicine
EHF transcriptionally inhibits the expressions of TGFβ1 and GM-CSF to decrease T reg cell and MDSC accumulation, making it a promising biomarker to evaluate the immune microenvironment in PDAC. EHF overexpression may improve the efficacy of checkpoi
Autor:
Thomas F. Gajewski, Kyle R. Cron
Publikováno v:
The Journal of Experimental Medicine
Type 1 conventional dendritic cells are progressively and systemically dysregulated during pancreatic carcinogenesis, subject to semimaturation and IL-6–driven apoptosis. Yet, CD40 agonist synergizes with Flt3L to rescue cDC1 abundance and maturati
Autor:
Ash A. Alizadeh, Kevin Sheehan, Neel K. Gupta, Debra K. Czerwinski, Malek Faham, Ole Audun Werner Haabeth, Andrew R. Rezvani, Ginna G. Laport, Michael P. Chu, Matthew J. Frank, Irene Wapnir, Sunil Reddy, Michael S. Khodadoust, Everett Meyer, Robert S. Negrin, Ami Okada, David B. Miklos, Ranjana H. Advani, Joshua Brody, Destiny L Phillips, Lauren S. Maeda, Ronald Levy, A Holliston Moore, Wen-Kai Weng
Publikováno v:
The Journal of Experimental Medicine
A CpG-stimulated autologous tumor cell vaccine for patients with MCL is safe and feasible and induces detectable antitumor T cell immune responses. Patients who received the CpG-MCL vaccination demonstrated freedom from MRD at 1 yr after ASCT that su
Autor:
Haowen Ran, Jianghong Man, Lanjuan Mi, Da Li, Xu Yan, Jin Wu, Tao Li, Jeremy N. Rich, Sai-Sai Guo, Dake Xiao, Xiao-Yan Zhan, Songyang Zhang, Haohao Huang, Jiuwei Cui, Kun He, Yuanyuan Li, Lishu Chen, Zhang Xuemin, Xinzheng Wang, Tao Zhou, Qiu-Ying Han, Yu Yu, Tingting Li, Ailing Li, Shideng Bao
Publikováno v:
The Journal of Experimental Medicine
Zhan et al. reveal that glioma stem-like cells (GSCs) evade type I IFN suppression through MBD3/NuRD complex–mediated STAT1 downregulation, thereby allowing GSCs to initiate a tumor in the inhospitable microenvironment in glioblastoma (GBM).
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Autor:
Kelly Mitchell, Tihomira I. Todorova, Laura Barreyro, Joana Leite, Iléana Antony-Debré, Ioannis Mantzaris, Amit Verma, Samuel J. Taylor, Elisabeth Paietta, Gopichand Pendurti, Swathi Rao Narayanagari, Ulrich Steidl, Luis A. Carvajal, Zubair Piperdi, Kira Gritsman
Publikováno v:
The Journal of Experimental Medicine
IL1RAP is an emerging target for AML therapy. Studying its cell-intrinsic function revealed that IL1RAP interacts with and amplifies signaling through c-KIT and FLT3 in AML cells. This novel promiscuous role of IL1RAP in AML has implications for ther
Autor:
Johan Skog, Carmen García-Martín, Iwona Kalinowska, Susana García-Silva, Alberto Benito-Martin, Pablo L. Ortiz-Romero, Yolanda Ruano, Marina S. Mazariegos, Alberto Hernández-Barranco, Mercedes Robledo, Mary Sue Brady, Carlos F. Rodríguez, Kay Brinkmann, Piotr Rutkowski, Javier Munoz, Ana Amor López, Pilar Ximénez-Embún, Anna Szumera-Ciećkiewicz, Cristina Montero, Rocío Letón, José Luis Rodríguez-Peralto, Laura Santambrogio, Mikkel Noerholm, Sara Sánchez-Redondo, Laura Nogués, Héctor Peinado, Lisa Meyer, Jasminka Boskovic
Publikováno v:
The Journal of Experimental Medicine
Liquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogate markers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting. We h
Autor:
Benjamin L. Green, Teresa S. Kim, Rachel Popow, Vinod P. Balachandran, Jonathan B. Greer, Megan H. Crawley, Peter Besmer, Ferdinand Rossi, Cristina R. Antonescu, Shan Zeng, Michael J. Cavnar, Noah A. Cohen, Adrian M. Seifert, Lee M. Ocuin, Eric C. Sorenson, Ronald P. DeMatteo
Publikováno v:
The Journal of Experimental Medicine
Imatinib reduces tumor cell KIT signaling and causes tumor cell apoptosis, which drives TAMs to shift from M1- to M2-like in mouse and human GIST.
Tumor-associated macrophages (TAMs) are a major component of the cancer microenvironment. Modulati
Tumor-associated macrophages (TAMs) are a major component of the cancer microenvironment. Modulati
Autor:
Liqing Jin, Jayne S. Danska, Po-Yan Cheng, Nico van Rooijen, John E. Dick, Andrei V. Malko, Jenny M.-Y. Ho, Jean C.Y. Wang, Alexandre Theocharides, Tatiana K. Prasolava, Armando G. Poeppl, Mark D. Minden
Publikováno v:
The Journal of Experimental Medicine
Theocharides, A P A, Jin, L Q, Cheng, P Y, Prasolava, T K, Malko, A V, Ho, J M, Poeppl, A G, van Rooijen, N, Minden, M D, Danska, J S, Dick, J & Wang, J C Y 2012, ' Disruption of SIRP alpha signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts ', Journal of Experimental Medicine, vol. 209, no. 10, pp. 1883-1899 . https://doi.org/10.1084/jem.20120502
Journal of Experimental Medicine, 209(10), 1883-1899. Rockefeller University Press
Theocharides, A P A, Jin, L Q, Cheng, P Y, Prasolava, T K, Malko, A V, Ho, J M, Poeppl, A G, van Rooijen, N, Minden, M D, Danska, J S, Dick, J & Wang, J C Y 2012, ' Disruption of SIRP alpha signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts ', Journal of Experimental Medicine, vol. 209, no. 10, pp. 1883-1899 . https://doi.org/10.1084/jem.20120502
Journal of Experimental Medicine, 209(10), 1883-1899. Rockefeller University Press
Inhibition of macrophage SIRPα–CD47 interactions mediates phagocytosis and clearance of acute myeloid leukemia stem cells.
Although tumor surveillance by T and B lymphocytes is well studied, the role of innate immune cells, in particular macr
Although tumor surveillance by T and B lymphocytes is well studied, the role of innate immune cells, in particular macr
Autor:
Roberto N. Miranda, Mark J. Kiel, David T. Yang, Nathanael G. Bailey, David W. Bahler, Megan S. Lim, Govind Bhagat, L. Jeffrey Medeiros, Bryan L. Betz, Lili Zhao, David R. Huebner-Chan, Mark Y. Chiang, Helmut G. Weigelin, Kojo S.J. Elenitoba-Johnson, Thirunavukkarasu Velusamy
Publikováno v:
The Journal of Experimental Medicine
NOTCH2 mutations in splenic marginal zone lymphoma are associated with poor prognosis.
Splenic marginal zone lymphoma (SMZL), the most common primary lymphoma of spleen, is poorly understood at the genetic level. In this study, using whole-genom
Splenic marginal zone lymphoma (SMZL), the most common primary lymphoma of spleen, is poorly understood at the genetic level. In this study, using whole-genom
Autor:
Carmelo Nucera, Shavali Shaik, Hidefumi Fukushima, Hiroyuki Inuzuka, Vania Nosé, Wenyi Wei, Jack Lawler, Amjad Husain, Trista E. North, Gregory M. Frechette, Wolfram Goessling, Maija K. Garnaas, Guido Fadda, Daming Gao, Peter M. Sadow, Lixin Wan, Lauren Harris
Publikováno v:
The Journal of Experimental Medicine
The E3 ubiquitin ligase β-TRCP, acting in concert with casein kinase I, drives ubiquitination and degradation of VEGFR2, and renders human papillary thyroid cancer cells resistant to the VEGFR2 inhibitor sorafenib.
The incidence of human papill
The incidence of human papill