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Autor:
Panagiotis Mistriotis, Petr Kalab, Kaustav Bera, Yuqi Zhang, Konstantinos Konstantopoulos, Runchen Zhao, Sean X. Sun, Nicolas A. Perez-Gonzalez, Emily Wisniewski, Jeremy Keys, Jan Lammerding, Soontorn Tuntithavornwat, Yizeng Li, Eda Erdogmus, Robert A. Law
Publikováno v:
The Journal of Cell Biology
The nucleus is a significant obstacle that impedes migration of cells through confining microenvironments. Mistriotis et al. propose a conceptual model in which confinement-induced RhoA/myosin-II activation promotes nuclear volume expansion, nuclear
Autor:
Dora Tortarolo, Guido Serini, Chiara Sandri, Donatella Valdembri, Giulia Villari, Matteo Astone, Marco Arese, Chiara Camillo, Roxana E. Oberkersch, Dafne Gays, Noemi Gioelli, Fabiana Clapero, Giulia Mana, Massimo M. Santoro, Nicola Facchinello, Luca Tamagnone
Publikováno v:
bioRxiv
Dynamic modulation of endothelial cell-to-cell and cell-to-extracellular matrix (ECM) adhesion is essential for blood vessel patterning and functioning. Yet, the molecular mechanisms involved in this process have not been completely deciphered. We id
Autor:
Dimitrios K. Papadopoulos, Christos Samakovlis, Kassiani Skouloudaki, Pavel Tomancak, Elisabeth Knust, Dilan Khalili, Vasilios Tsarouhas, Ioannis Christodoulou
Publikováno v:
The Journal of Cell Biology
Skouloudaki, K, Christodoulou, I, Khalili, D, Tsarouhas, V, Samakovlis, C, Tomancak, P, Knust, E & Papadopoulos, D K 2019, ' Yorkie controls tube length and apical barrier integrity during airway development ', Journal of Cell Biology, vol. 218, no. 8, pp. 2762-2781 . https://doi.org/10.1083/jcb.201809121
Skouloudaki, K, Christodoulou, I, Khalili, D, Tsarouhas, V, Samakovlis, C, Tomancak, P, Knust, E & Papadopoulos, D K 2019, ' Yorkie controls tube length and apical barrier integrity during airway development ', Journal of Cell Biology, vol. 218, no. 8, pp. 2762-2781 . https://doi.org/10.1083/jcb.201809121
Skouloudaki et al. identify an alternative role of the transcriptional coactivator Yorkie (Yki) in controlling water impermeability and tube size of developing Drosophila airways. Tracheal impermeability is triggered by Yki-mediated transcriptional r
Autor:
Jean Gautier, Benjamin R. Schrank
Publikováno v:
The Journal of Cell Biology
Schrank and Gautier discuss the generation and function of nuclear domains during DNA repair with a special focus on nuclear actin polymerization.
Eukaryotic nuclei are organized into nuclear domains that unite loci sharing a common function. Th
Eukaryotic nuclei are organized into nuclear domains that unite loci sharing a common function. Th
Autor:
Fan Gao, Neeraj Kumar Singh, Qingyuan Fan, Manoshi Gayen, Riqiang Yan, Wanxia He, Xiangyou Hu, Li-Huei Tsai
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine (JEM)
Journal of Experimental Medicine (JEM)
The membrane-anchored CX3CL1 is best known to exert its signaling function through binding its receptor CX3CR1. This study demonstrates a novel function that CX3CL1 exerts. CX3CL1 is sequentially cleaved by α-, β-, and γ-secretase, and the release
Autor:
Ardalan Naseri, Shaojie Zhang, Thoru Pederson, David Grunwald, Li-Chun Tu, Hanhui Ma, Yu-Chieh Chung
Publikováno v:
The Journal of Cell Biology
Ma et al. use the CRISPR-Sirius system to track the dynamics of genomic loci situated kilobases to megabases apart on a single chromosome throughout the cell cycle, providing insight into the compaction–relaxation dynamics of the interphase chromos
Publikováno v:
The Journal of Cell Biology
Kinesin-binding protein (KBP) is identified as a regulator of the kinesins KIF18A and KIF15 during mitosis. KBP buffers the activity of these motors to control chromosome alignment and spindle integrity in metaphase and prevent lagging chromosomes in
Publikováno v:
The Journal of Cell Biology
Maass et al. review interchromosomal interactions, which, like intrachromosomal interactions, are emerging as important regulators of genome organization and gene expression.
Nuclei require a precise three- and four-dimensional organization of D
Nuclei require a precise three- and four-dimensional organization of D
Autor:
Holger Jastrow, Beate Sodeik, Christiane Silke Heilingloh, Katinka Döhner, Aykut Turan, Alexandra Düthorn, Mirko Kummer, Sylvia Voortmann, Christina Drassner, Niels Schaft, Alexander Steinkasserer, Petra Mühl-Zürbes, Jan Dörrie, Mike Hasenberg, Adalbert Krawczyk, Max E. Kraner, Linda Grosche
Publikováno v:
The Journal of Cell Biology
Florence Niedergang introduces work by Turan et al. demonstrating that herpes virus egress from dendritic cells is differentially regulated by kinesin-dependent positioning of lysosomes and autophagic degradation of nuclear lamins.
Herpes simple
Herpes simple
Publikováno v:
The Journal of Cell Biology
Vermunt et al. discuss the relationship between gene-regulatory elements and nuclear architectural features in transcription.
Imaging studies, high-resolution chromatin conformation maps, and genome-wide occupancy data of architectural proteins
Imaging studies, high-resolution chromatin conformation maps, and genome-wide occupancy data of architectural proteins