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Autor:
Steffen Wöllner, Mario Drewello, Gunter Fischer, Angelika Schierhorn, Gerd Scherer, Ulf Reimer, Mike Schutkowski, Mario Jakob
Publikováno v:
FEBS Letters. (3):289-294
Oligopeptides derived from the gag polyprotein (Pr55gag) of human immunodeficiency virus type 1 (HIV-1) segment were used to evaluate the extension of the putative binding region for the complex of Pr55gag and the human cytosolic peptidyl prolyl cisl
Publikováno v:
FEBS Letters. (1-2):37-41
We describe here Ro 46-8443, the first non-peptide endothelin ETB receptor selective antagonist. It displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel ri
Publikováno v:
FEBS Letters. (1):55-58
Adherence of pathogenic bacteria to epithelial surfaces is considered an important first step' in infective processes. In the case of Escherichia coli, hair-like structures at the surface of the cell, referred to as fimbriae or pili are supposedly in
Publikováno v:
FEBS Letters. (1):125-129
The extracellular domains of the TrkA and TrkB neurotrophin receptors contain defined structural modules such as immunoglobulin-like domains and leucine-rich motifs (LRMs) [Schneider and Schweiger, Oncogene 6 (1991) 1807–1811]. Recently, the second
Publikováno v:
FEBS Letters. (2):281-285
Publikováno v:
FEBS Letters. (23):4507-4511
Nuclear factor of kappaB (NF-kappaB) is a major transcription factor regulating the expression of interleukin-2 (IL-2) and interleukin-2 receptor-alpha (IL-2Ralpha) in Th(1) cells. We previously demonstrated that zinc increased IL-2 and IL-2Ralpha pr
Autor:
Tanjef Szellas, Georg Nagel
Publikováno v:
FEBS Letters. (1-3):141-146
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel which is activated by protein phosphorylation and nucleoside triphosphates. We demonstrate here that fusion of the soluble catalytic subunit of cAMP-dependent protei
Autor:
Kazunari Taira, Koh Yamamoto, Osamu Kaminuma, Fujiko Kitamura, Shoichiro Miyatake, Osamu Miura, Noriko Kitamura, Makoto Miyagishi
Publikováno v:
FEBS Letters. (1-3):63-68
The regulatory mechanism by which GATA-3 suppresses IFN-gamma gene expression was investigated. A reduction of GATA-3 using RNA interference technology enhanced, whereas overexpression of GATA-3 suppressed IFN-gamma mRNA expression. IL-4 expression w
Publikováno v:
FEBS Letters. (2-3):159-163
Ecotin, a serine protease inhibitor found in the periplasm of Escherichia coli , has been characterized as a potent reversible tight-binding inhibitor of the human contact activation proteases factor XIIa (FXIIa) and plasma kallikrein, having K i val
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (1):45-54
Recurrent venous thrombosis, arterial thrombosis and pregnancy losses are clinical manifestation associated with antiphospholipid antibody (aPL) that recognizes negatively charged phospholipid antigens. Enzyme-linked immunosorbent assays (ELISA) are