Zobrazeno 1 - 10
of 21
pro vyhledávání: '"James A. Brown"'
Autor:
Jessy S. Deshane, Shannon K. Boi, Kenneth G. Nepple, Laura A. Bertrand, James A. Brown, Megan Bing, Lyse A. Norian, Lewis Thomas, Gal Wald, Claire Buchta Rosean, Jennifer B. Gordetsky, Peng Li, Katlyn E Norris, Justin T. Gibson
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233795 (2020)
PLoS ONE
PLoS ONE
Understanding the effects of obesity on the immune profile of renal cell carcinoma (RCC) patients is critical, given the rising use of immunotherapies to treat advanced disease and recent reports of differential cancer immunotherapy outcomes with obe
Autor:
Ivan Melendez-Rivera, Douglas J. Ward, Joseph Horton, James R. Brown, Daniel Murphy, Samiul Hasan, Edwin DeJesus, Jonathon Uy, Martin Potter, Anthony LaMarca, Mark S. Shaefer, Lisa L. Ross
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89611 (2014)
PLoS ONE
PLoS ONE
Factors that contribute to the transmission of human immunodeficiency virus type 1 (HIV-1), especially drug-resistant HIV-1 variants remain a significant public health concern. In-depth phylogenetic analyses of viral sequences obtained in the screeni
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75607 (2013)
PLoS ONE
PLoS ONE
Respiratory bacterial pathogens are one of the leading causes of infectious death in the world and a major health concern complicated by the rise of multi-antibiotic resistant strains. Therapeutics that modulate host genes essential for pathogen infe
Autor:
William R. Burnside, Marcus J. Hamilton, Jeffrey C. Nekola, Jordan G. Okie, Trevor S. Fristoe, James H. Brown, Joseph R. Burger, Ana D. Davidson, Craig D. Allen, Wenyun Zuo, Norman Mercado-Silva
Publikováno v:
PLoS Biology, Vol 10, Iss 6, p e1001345 (2012)
PLoS Biology
PLoS Biology
Global consumption rates of vital resources suggest that we have surpassed the capacity of the Earth to sustain current levels, much less future trajectories of growth in human population and economy.
The discipline of sustainability science has
The discipline of sustainability science has
Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models
Autor:
Stephanie Van Horn, David L. Mayhew, Elizabeth Thomas, Lihong Chen, Jean-Louis Klein, Vinod Kumar, Ganesh M. Sathe, George P. Livi, James R. Brown, David J. Holmes, Karen A. Ingraham, Aaron Spivak, Deepak K. Rajpal, Mark A. Paulik, Joyce A. Boucheron
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145499 (2015)
PLoS ONE
PLoS ONE
The gastrointestinal tract microbiome has been suggested as a potential therapeutic target for metabolic diseases such as obesity and Type 2 diabetes mellitus (T2DM). However, the relationship between changes in microbial communities and metabolic di
Autor:
Elizabeth Thomas, Deepak K. Rajpal, David Baker, Andrew W. Nicholls, Sam R. Miller, Derek J. Nunez, Antonella Napolitano, James R. Brown, Stephanie Van Horn, Aaron Spivak
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 7, p e100778 (2014)
PLoS ONE, Vol 9, Iss 7, p e100778 (2014)
UnlabelledMetformin, a biguanide derivate, has pleiotropic effects beyond glucose reduction, including improvement of lipid profiles and lowering microvascular and macrovascular complications associated with type 2 diabetes mellitus (T2DM). These eff
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 3, p e33174 (2012)
PLoS ONE, Vol 7, Iss 3, p e33174 (2012)
Background Pandemic and seasonal respiratory viruses are a major global health concern. Given the genetic diversity of respiratory viruses and the emergence of drug resistant strains, the targeted disruption of human host-virus interactions is a pote
Autor:
Courtney Yong, Devon L Moose, Nadine Bannick, Wade R Gutierrez, Marion Vanneste, Robert Svensson, Patrick Breheny, James A Brown, Rebecca D Dodd, Michael B Cohen, Michael D Henry
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0232807 (2020)
Here we have improved an existing mouse model of prostate cancer based on prostate-specific deletion of Pten and Trp53 by incorporating a Cre-activatable luciferase reporter. By coupling the deletion of those genes to the activation of a luciferase r
Externí odkaz:
https://doaj.org/article/ce7d1f3ddce84cf390873022563396c7
Autor:
Justin T Gibson, Katlyn E Norris, Gal Wald, Claire M Buchta Rosean, Lewis J Thomas, Shannon K Boi, Laura A Bertrand, Megan Bing, Jennifer B Gordetsky, Jessy Deshane, Peng Li, James A Brown, Kenneth G Nepple, Lyse A Norian
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233795 (2020)
Understanding the effects of obesity on the immune profile of renal cell carcinoma (RCC) patients is critical, given the rising use of immunotherapies to treat advanced disease and recent reports of differential cancer immunotherapy outcomes with obe
Externí odkaz:
https://doaj.org/article/ad0135c8e8374a1c905d5a81d2e63135
Autor:
Melisa L Wong, Ying Shi, Kathy Z Fung, Sarah Ngo, Brett M Elicker, James K Brown, Robert A Hiatt, Victoria L Tang, Louise C Walter
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200496 (2018)
BACKGROUND:Pulmonary nodule guidelines do not indicate how to individualize follow-up according to comorbidity or life expectancy. OBJECTIVES:To characterize comorbidity and life expectancy in older veterans with incidental, symptom-detected, or scre
Externí odkaz:
https://doaj.org/article/a0658defccb34bcc95c5ccfea46318d7