Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Blake, R. P."'
Autor:
Tian-Yeh Lim, Blake R Wilde, Mallory L Thomas, Kristin E Murphy, Jeffery M Vahrenkamp, Megan E Conway, Katherine E Varley, Jason Gertz, Donald E Ayer
Publikováno v:
PLoS Biology, Vol 21, Iss 3, p e3001778 (2023)
The c-Myc protooncogene places a demand on glucose uptake to drive glucose-dependent biosynthetic pathways. To meet this demand, c-Myc protein (Myc henceforth) drives the expression of glucose transporters, glycolytic enzymes, and represses the expre
Externí odkaz:
https://doaj.org/article/7572474847da4aaf9911a7ea46d99e21
Autor:
Shuang Li, Yuanyuan Li, Blake R Rushing, Sarah E Harris, Susan L McRitchie, Janice C Jones, Daniel Dominguez, Susan J Sumner, Henrik G Dohlman
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009640 (2021)
Heterotrimeric G proteins were originally discovered through efforts to understand the effects of hormones, such as glucagon and epinephrine, on glucose metabolism. On the other hand, many cellular metabolites, including glucose, serve as ligands for
Externí odkaz:
https://doaj.org/article/b1d6d008d7d84ee7807ee27521839932
Autor:
Saida Benomar, Patrick Lansdon, Aaron M Bender, Blake R Peterson, Josephine R Chandler, Brian D Ackley
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008134 (2020)
Caenorhabditis elegans are soil-dwelling nematodes and models for understanding innate immunity and infection. Previously, we developed a novel fluorescent dye (KR35) that accumulates in the intestine of C. elegans and reports a dynamic wave in intes
Externí odkaz:
https://doaj.org/article/51b0401b71c24aafb24cf5aabf52ffb8
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 5, p e1006976 (2019)
Gene-expression deconvolution is used to quantify different types of cells in a mixed population. It provides a highly promising solution to rapidly characterize the tumor-infiltrating immune landscape and identify cold cancers. However, a major chal
Externí odkaz:
https://doaj.org/article/e1a1448a77af46a9b55fa275f695a5c2
Autor:
Adam J Sepulveda, Michael T Tercek, Robert Al-Chokhachy, Andrew M Ray, David P Thoma, Blake R Hossack, Gregory T Pederson, Ann W Rodman, Tom Olliff
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145060 (2015)
Knowledge of climatic variability at small spatial extents (< 50 km) is needed to assess vulnerabilities of biological reserves to climate change. We used empirical and modeled weather station data to test if climate change has increased the synchron
Externí odkaz:
https://doaj.org/article/e071b42747c54742b76c9e0d0b3ddc43
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003709 (2013)
In an effort to suppress microbial outgrowth, the host sequesters essential nutrients in a process termed nutritional immunity. However, inflammatory responses to bacterial insult can restore nutritional resources. Given that nutrient availability mo
Externí odkaz:
https://doaj.org/article/03563b9b75ff42db8a87a792171b205f
Autor:
Jamie J Arnold, Suresh D Sharma, Joy Y Feng, Adrian S Ray, Eric D Smidansky, Maria L Kireeva, Aesop Cho, Jason Perry, Jennifer E Vela, Yeojin Park, Yili Xu, Yang Tian, Darius Babusis, Ona Barauskus, Blake R Peterson, Averell Gnatt, Mikhail Kashlev, Weidong Zhong, Craig E Cameron
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1003030 (2012)
Ribonucleoside analogues have potential utility as anti-viral, -parasitic, -bacterial and -cancer agents. However, their clinical applications have been limited by off target effects. Development of antiviral ribonucleosides for treatment of hepatiti
Externí odkaz:
https://doaj.org/article/b319ca8392e34c9a89590b29d3f91226