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Autor:
Ferdia A. Gallagher, Wendi Qian, Fulvio Zaccagna, Stephan Ursprung, Grant D. Stewart, Anne Y. Warren, Sarah J. Welsh, Tristan Barrett, Timothy Eisen, Andrew N. Priest, Andrea Machin
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258988 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258988 (2021)
Funder: NIHR Cambridge Biomedical Research Centre
Funder: Addenbrooke’s Charitable Trust
Funder: National Institute for Health Research (NIHR)
Funder: Mark Foundation For Cancer Research
Funder: Cambridge Commonwealth, European
Funder: Addenbrooke’s Charitable Trust
Funder: National Institute for Health Research (NIHR)
Funder: Mark Foundation For Cancer Research
Funder: Cambridge Commonwealth, European
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175576bf7192b19e2d8f1d92a44d8c2e
Autor:
Sven Peine, Marissa Herrmann, Hendrik Karsten, Marc Lütgehetmann, Matthias Marget, Matin Kohsar, William W. Kwok, John Sidney, Janna Heide, Sophia Schulte, Alessandro Sette, Julian Schulze zur Wiesch, Alexandra M. Johansson, Thomas Theo Brehm
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1 (2022)
PLoS Pathogens, Vol 17, Iss 9, p e1009842 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010220 (2022)
PLoS Pathogens, Vol 17, Iss 9, p e1009842 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010220 (2022)
The aim of this study was to define the breadth and specificity of dominant SARS-CoV-2-specific T cell epitopes using a comprehensive set of 135 overlapping 15-mer peptides covering the SARS-CoV-2 envelope (E), membrane (M) and nucleoprotein (N) in a
Serum miR-192-5p levels predict the efficacy of pegylated interferon therapy for chronic hepatitis B
Autor:
Hiroki Ikeda, Akihiro Matsumoto, Masataka Tsuge, Takako Inoue, Masakuni Tateyama, Kentaro Matsuura, Tsunamasa Watanabe, Masanori Atsukawa, Eiji Tanaka, Takeshi Matsui, Masaru Enomoto, Yasuhito Tanaka, Shuhei Nishiguchi, Jong-Hon Kang, Chiaki Okuse, Yoshihito Nagura, Hiromi Kataoka, Etsuko Iio, Koji Fujita
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263844 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263844 (2022)
We examined the association between serum miRNA (-192-5p, -122-3p, -320a and -6126-5p) levels and the efficacy of pegylated interferon (Peg-IFN) monotherapy for chronic hepatitis B (CHB) patients. We enrolled 61 CHB patients treated with Peg-IFNα-2a
Autor:
Therese Sheppard, Usman Iqbal, Robyn Tamblyn, Jack Shiansong Li, David L. Buckeridge, Meghna Jani, Shelly A. Vik, David W. Bates, Colin Weaver, Nadyne Girard, William G Dixon, Judy E. Seidel
Publikováno v:
PLoS Medicine, Vol 18, Iss 11 (2021)
Jani, M, Girard, N, Bates, D, Buckeridge, D, Sheppard, T, Li, J S, Iqbal, U, Vik, S, Weaver, C, Seidel, J, Dixon, W & Tamblyn, R 2021, ' Opioid prescribing among new users for non-cancer pain in USA, Canada, UK and Taiwan : a population-based cohort study ', PL o S Medicine, vol. 18, no. 11, e1003829, pp. 1-15 . https://doi.org/10.1371/journal.pmed.1003829
PLoS Medicine
PLoS Medicine, Vol 18, Iss 11, p e1003829 (2021)
Jani, M, Girard, N, Bates, D, Buckeridge, D, Sheppard, T, Li, J S, Iqbal, U, Vik, S, Weaver, C, Seidel, J, Dixon, W & Tamblyn, R 2021, ' Opioid prescribing among new users for non-cancer pain in USA, Canada, UK and Taiwan : a population-based cohort study ', PL o S Medicine, vol. 18, no. 11, e1003829, pp. 1-15 . https://doi.org/10.1371/journal.pmed.1003829
PLoS Medicine
PLoS Medicine, Vol 18, Iss 11, p e1003829 (2021)
Background The opioid epidemic in North America has been driven by an increase in the use and potency of prescription opioids, with ensuing excessive opioid-related deaths. Internationally, there are lower rates of opioid-related mortality, possibly
Autor:
Sylvain Mutanda, Medard Ilunga, Olaf Valverde Mordt, Digas Ngolo Tete, Wilfried Mutombo, Caecilia Schmid, Victor Kande, Séverine Blesson, Andrea Kuemmerle, Ismael Lumpungu, Christian Burri, Mays Kisala, Sonja Bernhard, Pathou Nganzobo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009903 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
PLoS Neglected Tropical Diseases
Background Nifurtimox-eflornithine combination therapy (NECT) for the treatment of second stage gambiense human African trypanosomiasis (HAT) was added to the World Health Organization’s Essential Medicines List in 2009 after demonstration of its n
Autor:
Louis Scampavia, Claudia M. Rohr, Timothy P. Spicer, Evgeny G. Chulkov, Sang-Kyu Park, Jonathan S. Marchant, Emery Smith, Nawal A. Yahya
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009898 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009898 (2021)
Given the worldwide burden of neglected tropical diseases, there is ongoing need to develop novel anthelmintic agents to strengthen the pipeline of drugs to combat these burdensome infections. Many diseases caused by parasitic flatworms are treated u
Autor:
Li Sheng, Yan Zhang, Xiaoying Xu, Zongjie Hou, Jianghua Wang, Chong Chen, Xingming Ma, Yanping Luo, Qingxia Yang, Zhi Li, Qi He
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009927 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
The metacestode stage of Echinococcus granulosus can cause cystic echinococcosis (CE), which still widely occurs around the world. Since the early 1970s, benzimidazoles have been shown to inhibit the growth of cysts and used to treat CE. However, ben
Autor:
Mitali Chatterjee, Shilpa Sengupta
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009906 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009906 (2021)
PLoS Neglected Tropical Diseases
Background The assessment of chemotherapeutic responses in Post Kala-azar Dermal Leishmaniasis (PKDL), especially its macular form is challenging, emphasizing the necessity for ‘test of cure’ tools. This study explored the diagnostic and prognost
Autor:
Leena Omereltinai, Muzamil Mahdi Abdel Hamid, Abdelrahim O. Mohamad, Sara B. Eltom, Nouh S. Mohamed, Musab M. Ali Albsheer, Andrew A. Lover, Mohamed S. Muneer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009720 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009720 (2021)
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is the most common enzymopathy globally, and deficient individuals may experience severe hemolysis following treatment with 8-aminoquinolines. With increasing evidence of Plasmodium vivax infection
Autor:
Mio Ayana, Martin Walker, Antonio Montresor, Jennifer Keiser, Marco Albonico, Zeleke Mekonnen, Leonardo Ferreira Matoso, Somphou Sayasone, Johnny Vlaminck, Piet Cools, Daniel Dana, Jozef Vercruysse, Rodrigo Correa-Oliveira, Bruno Levecke, Simone A. Pinto, Shaali M. Ame
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009888 (2021)
PLOS NEGLECTED TROPICAL DISEASES
PLoS Neglected Tropical Diseases
PLOS NEGLECTED TROPICAL DISEASES
PLoS Neglected Tropical Diseases
Background Albendazole (ALB) is administered annually to millions of children through global deworming programs targeting soil-transmitted helminths (STHs: Ascaris lumbricoides, Trichuris trichiura and hookworms, Necator americanus and Ancylostoma du