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Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243789 (2020)
PLoS ONE
PLoS ONE
Native intact N-glycopeptide analysis can provide access to the comprehensive characteristics of N-glycan occupancy, including N-glycosites, N-glycan compositions, and N-glycoproteins for complex samples. The sample pre-processing method used for the
Autor:
Seung Beom Han, Seung Baik Kang, Hee Gon Park, Sung-Hwan Kim, Young Wan Moon, Kang Il Kim, Moon Jong Chang, Sahnghoon Lee, Joung Youp Shin, Jae Doo Yoo, Myung Ku Kim, Han Jun Lee
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238024 (2020)
PLoS ONE
PLoS ONE
IntroductionAt present, information about clinical efficacy and adverse events of controlled release (CR) form of pelubiprofen, a prodrug of 2-arylopropionic acid with relatively selective effects on cyclooxygenase-2 activity, remains scarce. In this
Autor:
Alain Saga Ouermi, Boubacar Nacro, Ouédraogo Abdoul Salam, Ad Bafa Ibrahim Ouattara, Bintou Sanogo, Anselme Millogo, Makoura Barro
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241789 (2020)
PLoS ONE
PLoS ONE
Objective Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children. Method Sensitivity, specificity, Positive Predictive
Autor:
Takashi Sakaguchi, Hideki Enokida, Hirofumi Yoshino, Kazuki Kuroshima, Masafumi Tsuruda, Yasutoshi Yamada, Masayuki Nakagawa, Satoshi Sugita, Shuichi Tatarano, Yoichi Osako
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236119 (2020)
PLoS ONE
PLoS ONE
The alcohol-abuse drug disulfiram has antitumor effects against diverse cancer types via inhibition of the ubiquitin-proteasome protein nuclear protein localization protein 4 (NPL4). However, the antitumor effects of NPL4 and disulfiram in clear cell
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228027 (2020)
PLoS ONE
PLoS ONE
BACKGROUND: The slope of the relationship between segmental PreS and total systolic shortening (S) has been proposed as a non-invasive index of left ventricular contractility. The aim of this study was to correlate this novel parameter to invasive go
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230261 (2020)
PLoS ONE
PLoS ONE
Background We aimed to evaluate the expression of APOBEC3A (A3A), 3B (A3B) mRNA, and germline APOBEC3A/B deletion polymorphism in patients with breast cancers and to investigate the correlation between their expressions and clinicopathological charac
Autor:
Haridarshan Patel, Katie J. Suda, Robert J. DiDomenico, Glen T. Schumock, Gregory S. Calip, Todd A. Lee
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240379 (2020)
PLoS ONE
PLoS ONE
Previous studies have suggested an increased risk of cardiac events with azithromycin, but the predictors of such events are unknown. We sought to develop and validate two prediction models to identify such predictors. We used data from Truven Market
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 1, p e1007218 (2020)
PLoS Computational Biology
PLoS Computational Biology, Public Library of Science, 2020, 16 (1), pp.e1007218. ⟨10.1371/journal.pcbi.1007218⟩
PLoS Computational Biology
PLoS Computational Biology, Public Library of Science, 2020, 16 (1), pp.e1007218. ⟨10.1371/journal.pcbi.1007218⟩
Precision medicine requires accurate technologies for drug administration and proper systems pharmacology approaches for patient data analysis. Here, plasma pharmacokinetics (PK) data of the OPTILIV trial in which cancer patients received oxaliplatin
Autor:
Nicolaas P.A. Zuithoff, Joyce L. Browne, Kitty W. M. Bloemenkamp, Lachmi R. Kodan, Marcus J. Rijken, Zita D. Prüst, Antoon W Grünberg, Kim J. C. Verschueren, Kerstin Klipstein-Grobusch
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244087 (2020)
PLoS ONE
PLoS ONE, 15(12 December):e0244087. Public Library of Science
PLoS ONE
PLoS ONE, 15(12 December):e0244087. Public Library of Science
Background Postpartum hemorrhage (PPH) is the leading cause of direct maternal mortality globally and in Suriname. We aimed to study the prevalence, risk indicators, causes, and management of PPH to identify opportunities for PPH reduction. Methods A
Autor:
Valda D. Page, Osama K. Khattab, Knox H. Todd, Srinivas R. Banala, Carla L. Warneke, Sai Ching J. Yeung
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235461 (2020)
PLoS ONE
PLoS ONE
ObjectiveIntranasal fentanyl (INF) quickly and noninvasively relieves severe pain, whereas intravenous hydromorphone (IVH) reliably treats severe cancer pain but requires vascular access. The trial evaluated the efficacy of INF relative to IVH for tr