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Autor:
Sven Peine, Marissa Herrmann, Hendrik Karsten, Marc Lütgehetmann, Matthias Marget, Matin Kohsar, William W. Kwok, John Sidney, Janna Heide, Sophia Schulte, Alessandro Sette, Julian Schulze zur Wiesch, Alexandra M. Johansson, Thomas Theo Brehm
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1 (2022)
PLoS Pathogens, Vol 17, Iss 9, p e1009842 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010220 (2022)
PLoS Pathogens, Vol 17, Iss 9, p e1009842 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010220 (2022)
The aim of this study was to define the breadth and specificity of dominant SARS-CoV-2-specific T cell epitopes using a comprehensive set of 135 overlapping 15-mer peptides covering the SARS-CoV-2 envelope (E), membrane (M) and nucleoprotein (N) in a
Autor:
Khadija Khan, Gila Lustig, Farina Karim, Bernadett I Gosnell, Suzaan Marais, Prakash Jeena, Rohen Harrichandparsad, Anne Derache, Sandile Cele, Mahomed-Yunus S. Moosa, Ravindra K. Gupta, Katya Govender, Alex Sigal, Ntombi Ntshuba, Abigail Ngoepe, Vinod B. Patel, John H. Adamson, Henrik N. Kløverpris
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009871 (2021)
Lustig, G, Cele, S, Karim, F, Derache, A, Ngoepe, A, Khan, K, Gosnell, B I, Moosa, M Y S, Ntshuba, N, Marais, S, Jeena, P M, Govender, K, Adamson, J, Kløverpris, H, Gupta, R K, Harrichandparsad, R, Patel, V B & Sigal, A 2021, ' T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy ', PLOS Pathogens, vol. 17, no. 9, e1009871 . https://doi.org/10.1371/journal.ppat.1009871
PLoS Pathogens
Lustig, G, Cele, S, Karim, F, Derache, A, Ngoepe, A, Khan, K, Gosnell, B I, Moosa, M Y S, Ntshuba, N, Marais, S, Jeena, P M, Govender, K, Adamson, J, Kløverpris, H, Gupta, R K, Harrichandparsad, R, Patel, V B & Sigal, A 2021, ' T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy ', PLOS Pathogens, vol. 17, no. 9, e1009871 . https://doi.org/10.1371/journal.ppat.1009871
PLoS Pathogens
HIV cerebrospinal fluid (CSF) escape, where HIV is suppressed in blood but detectable in CSF, occurs when HIV persists in the CNS despite antiretroviral therapy (ART). To determine the virus producing cell type and whether lowered CSF ART levels are
Autor:
Dale B. Bosco, Hailong Dong, Yanlu Ying, Anthony D. Umpierre, Long Jun Wu, Yong Liu, Tingjun Chen, Aastha Dheer, Min Hee Yi, Jiaying Zheng
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001154 (2021)
Spinal microglia are highly responsive to peripheral nerve injury and are known to be a key player in pain. However, there has not been direct evidence showing that selective microglial activation in vivo is sufficient to induce chronic pain. Here, w
Autor:
Alfredo Q. Antoniazzi, Lady Katerine Serrano Mujica, Carolina dos Santos Amaral, Suzan Gonçalves Rosa, Cristina W. Nogueira, Valério M. Portela, William Schoenau, M. F. Fiorenza, Natalia P. Smirnova, Fabio V. Comim, Gabrielle Rebeca Everling Correa
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257418 (2021)
PLoS ONE
PLoS ONE
One of the major causes of early pregnancy loss is heat stress. In ruminants, interferon tau (IFNT) is the embryo signal to the mother. Once the interferon signaling pathway is activated, it drives gene expression for interferon-stimulated genes (ISG
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252439 (2021)
PLoS ONE
PLoS ONE
Background Hypoxia-inducible factor (HIF) prolyl hydroxylase domain inhibitors, which have recently become clinically available for treating renal anemia, are attracting attention for their novel mechanisms of action. Methods Relationships of reticul
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254167 (2021)
PLoS ONE
PLoS ONE
Dexamethasone provides benefits in patients with coronavirus disease 2019 (COVID-19), although data regarding immunological profiles and viral clearance are limited. This study aimed to evaluate for differences in biomarkers among patients with sever
Autor:
Stuart J. Armstrong, Mike Dennis, Geraint Davies, Faye Lanni, Susan A. Fotheringham, Debbie J Harris, Simon Clark, Ann Williams, Neil K Burton, Oliver Skinner, Nathan R Wiblin
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245922 (2021)
PLoS ONE
PLoS ONE
Optimised pre-clinical models are required for TB drug development to better predict the pharmacokinetics of anti-tuberculosis (anti-TB) drugs to shorten the time taken for novel drugs and combinations to be approved for clinical trial. Microdialysis
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251885 (2021)
PLoS ONE
PLoS ONE
It is widely recognized that innate macrophage immune reactions to implant debris are central to the inflammatory responses that drive biologic implant failure over the long term. Less common, adaptive lymphocyte immune reactions to implant debris, s
Autor:
Fabio Luise, Lucia Sammicheli, Irene Tassinari, Filippo Pieralli, Andrea Ungar, Chiara Beltrame, Riccardo Pini, Rossella Marcucci, Alessandro Milia, Francesca Innocenti, Margherita Giampieri, Alberto Fortini, Fulvio Pomero, Francesca Caldi, Antonio Mancini, Domenico Prisco, Antonio Faraone
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251966 (2021)
PLoS ONE
PLoS ONE
Objective The aim of this study was to assess the incidence of deep vein thrombosis (DVT) of the lower limbs, using serial compression ultrasound (CUS) surveillance, in acutely ill patients with COVID-19 pneumonia admitted to a non-ICU setting. Metho
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260469 (2021)
PLoS ONE
PLoS ONE
Purpose To evaluate changes in choroidal vascular structure and aqueous cytokine levels in eyes with vitreoretinal lymphoma (VRL) after intravitreal methotrexate (MTX) treatment. Methods In this retrospective study, VRL patients who visited our hospi