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Autor:
Leena Omereltinai, Muzamil Mahdi Abdel Hamid, Abdelrahim O. Mohamad, Sara B. Eltom, Nouh S. Mohamed, Musab M. Ali Albsheer, Andrew A. Lover, Mohamed S. Muneer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009720 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009720 (2021)
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is the most common enzymopathy globally, and deficient individuals may experience severe hemolysis following treatment with 8-aminoquinolines. With increasing evidence of Plasmodium vivax infection
Autor:
Mavuto Mukaka, Saorin Kim, Eva Christophel, Sim Kheng, Sinoun Muth, Didier Menard, J. Kevin Baird, Alexandra Kerleguer, Walter R. J. Taylor, Lucio Luzzatto, Pety Tor
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009690 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 2021, 15 (9), pp.e0009690. ⟨10.1371/journal.pntd.0009690⟩
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 2021, 15 (9), pp.e0009690. ⟨10.1371/journal.pntd.0009690⟩
Background Acute Plasmodium vivax malaria is associated with haemolysis, bone marrow suppression, reticulocytopenia, and post-treatment reticulocytosis leading to haemoglobin recovery. Little is known how malaria affects glucose-6-phosphate dehydroge
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009840 (2021)
bioRxiv
PLoS Pathogens
bioRxiv
PLoS Pathogens
COVID-19 vaccines based on the Spike protein of SARS-CoV-2 have been developed that appear to be largely successful in stopping infection. However, therapeutics that can help manage the disease are still required until immunity has been achieved glob
Autor:
Khadija Khan, Gila Lustig, Farina Karim, Bernadett I Gosnell, Suzaan Marais, Prakash Jeena, Rohen Harrichandparsad, Anne Derache, Sandile Cele, Mahomed-Yunus S. Moosa, Ravindra K. Gupta, Katya Govender, Alex Sigal, Ntombi Ntshuba, Abigail Ngoepe, Vinod B. Patel, John H. Adamson, Henrik N. Kløverpris
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009871 (2021)
Lustig, G, Cele, S, Karim, F, Derache, A, Ngoepe, A, Khan, K, Gosnell, B I, Moosa, M Y S, Ntshuba, N, Marais, S, Jeena, P M, Govender, K, Adamson, J, Kløverpris, H, Gupta, R K, Harrichandparsad, R, Patel, V B & Sigal, A 2021, ' T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy ', PLOS Pathogens, vol. 17, no. 9, e1009871 . https://doi.org/10.1371/journal.ppat.1009871
PLoS Pathogens
Lustig, G, Cele, S, Karim, F, Derache, A, Ngoepe, A, Khan, K, Gosnell, B I, Moosa, M Y S, Ntshuba, N, Marais, S, Jeena, P M, Govender, K, Adamson, J, Kløverpris, H, Gupta, R K, Harrichandparsad, R, Patel, V B & Sigal, A 2021, ' T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy ', PLOS Pathogens, vol. 17, no. 9, e1009871 . https://doi.org/10.1371/journal.ppat.1009871
PLoS Pathogens
HIV cerebrospinal fluid (CSF) escape, where HIV is suppressed in blood but detectable in CSF, occurs when HIV persists in the CNS despite antiretroviral therapy (ART). To determine the virus producing cell type and whether lowered CSF ART levels are
Autor:
Matthew T. Birnie, Alex Paterson, Diana A. Stavreva, YM Kershaw, Becky L. Conway-Campbell, Audrys G Pauza, Songjoon Baek, David Murphy, Mark F. Rogers, Benjamin P. Flynn, Sohyoung Kim, Gordon L. Hager, Stafford L. Lightman
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics
Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009110 (2021)
PLoS Computational Biology
PLoS Computational Biology
Ethanol is one of the most widely used recreational substances in the world and due to its ubiquitous use, ethanol abuse has been the cause of over 3.3 million deaths each year. In addition to its effects, ethanol’s primary metabolite, acetaldehyde
Autor:
Hilary Ranson, Gareth J Lycett, Linda Grigoraki, Ruth Cowlishaw, Tony Nolan, Martin J. Donnelly
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009556 (2021)
PLoS Genetics
PLoS Genetics
Insecticide resistance in Anopheles mosquitoes is a major obstacle in maintaining the momentum in reducing the malaria burden; mitigating strategies require improved understanding of the underlying mechanisms. Mutations in the target site of insectic
Autor:
Ndeye Marie Sene, Alioune Gaye, Diawo Diallo, Ibrahima Dia, Yamar Ba, El Hadji Malick Ngom, Mawlouth Diallo, Konstantinos Mavridis, John Vontas, Cheikh Tidiane Diagne, El Hadji Ndiaye
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009393 (2021)
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases
Aedes aegypti is the main epidemic vector of arboviruses in Africa. In Senegal, control activities are mainly limited to mitigation of epidemics, with limited information available for Ae. aegypti populations. A better understanding of the current Ae
Autor:
H. L. Lee, Rosilawati Rasli, Ruziyatul Aznieda Azmi, Mohd Zainuldin Taib, Nurulhusna Ab Hamid, Siti Futri Farahininajua Fikri, Nur Ayuni Nazarudin, Nazni Wasi Ahmad, Yoon Ling Cheong, Rusydi Najmuddin Norzali, Afiq Ahnaf Hafisool, Topek Omar, Khairul Asuad Muhamed, Nur Fadillah Hamdan, Harith Aswad Ismail, M. Khairuddin Che Ibrahim, Roziah Ali
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009205 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background In Malaysia, dengue remains a top priority disease and usage of insecticides is the main method for dengue vector control. Limited baseline insecticide resistance data in dengue hotspots has prompted us to conduct this study. The present s
Autor:
Montserrat Esteve, Joana Pérez de San Román, Felix Junyent, María J. Ramírez, Grasa Mm, Angelo Ledda, Francisco J. Gil-Bea, José Gulfo
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246930 (2021)
Universidad de Barcelona
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246930 (2021)
Corticosteroid-binding globulin (CBG) is the specific carrier of circulating glucocorticoids, but evidence suggests that it also plays an active role in modulating tissue glucocorticoid activity. CBG polymorphisms affecting its expression or affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa6b1310837c928c1c27d4dc46919cf
http://hdl.handle.net/2445/175036
http://hdl.handle.net/2445/175036