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Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0239108 (2021)
PLoS ONE
PLoS ONE
Retinal inflammation accelerates photoreceptor cell death caused by retinal degeneration. Minocycline, a semisynthetic broad-spectrum tetracycline antibiotic, has been previously reported to rescue photoreceptor cell death in retinal degeneration. We
Autor:
Fabio García-García, Gabriela López-Herrera, Héctor Romero-Ramírez, Amayrani Abrego-Peredo, Claudia Sandoval-Montes, Mónica Flores-Muñoz, Enrique Espinosa, Juan Carlos Rodríguez-Alba
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233138 (2020)
PLoS ONE
PLoS ONE
Naringenin is flavonoid mainly found in citrus fruits which has shown several biological properties. In this work, we evaluated the therapeutic potential of the flavonoid Naringenin. Five-month-old B6.MRL-Faslpr/J lupus-prone mice were administered d
Autor:
Deniz A. Ucar, Elizabeth C. Martin, Bridgette M. Collins-Burow, Matthew E. Burow, Sukhmani Gill, Hope E. Burks, Adam I. Riker, Henri Wathieu, Lucio Miele, Steven Elliott, Bruce A. Bunnell, Margarite D. Matossian, Rachel A. Sabol, Luis Del Valle, Jovanny Zabaleta, Tiffany C. Chang
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0226464 (2020)
PLoS ONE
PLoS ONE
Metaplastic breast carcinoma (MBC) is a clinically aggressive and rare subtype of breast cancer, with similar features to basal-like breast cancers. Due rapid growth rates and characteristic heterogeneity, MBC is often unresponsive to standard chemot
Autor:
Suzanne Mashtoub, Gordon S. Howarth, Lauren C. Chartier, Michelle L. Hebart, Alexandra L. Whittaker
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0228413 (2020)
PLoS ONE
PLoS ONE
Behavioural indicators of affective state, including burrowing, clinical scores and the Mouse Grimace Score have not yet been validated in mouse models of chronic gastrointestinal disease. Additionally, a comparison of these methods has not been char
Autor:
Toshio Mochizuki, Tomochika Maoka, Seiji Hashimoto, Takao Koike, Tetsuya Kawata, Takashi Shigematsu
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242332 (2020)
PLoS ONE
PLoS ONE
We have reported previously that renal hemodynamic abnormalities exist in the prediabetic stage of type II diabetic rats. At this prediabetic stage these rats have hyperinsulinemia, insulin resistance and metabolic syndrome. It is well known that ins
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258579 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258579 (2021)
Vitamin D3 (VD3) induces intestinal CYP3A that metabolizes orally administered anti-leukemic chemotherapeutic substrates dexamethasone (DEX) and dasatinib potentially causing a vitamin-drug interaction. To determine the impact of VD3 status on system
Autor:
Annu Devi, Kriti Negi, Gobardhan Das, Sultan Tousif, Ashima Bhaskar, Anand Ranganathan, Dhiraj Kumar Singh, Barnani Moitra, Ved Prakash Dwivedi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009805 (2021)
PLoS Pathogens
PLoS Pathogens
Tuberculosis (TB) remains a major health problem throughout the world with one third of the population latently infected and ~1.74 million deaths annually. Current therapy consists of multiple antibiotics and a lengthy treatment regimen, which is ass
Autor:
Keigo Kawashima, Chise Tateno, Federica Moalli, Hideyoshi Harashima, Ian Baudi, Yasuhito Tanaka, Masanori Isogawa, Hiroyasu Ito, Masaya Onishi, Matteo Iannacone, Yuji Ishida, Takaji Wakita, Tetsuya Ishikawa, Yusuke Sato
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009228 (2021)
PLoS Pathogens
PLoS Pathogens
Virus infection, such as hepatitis B virus (HBV), occasionally causes endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is counteractive machinery to ER stress, and the failure of UPR to cope with ER stress results in cell death.
Autor:
Kai Man Cheng, Ashley N. Chandra, Sayanthooran Saravanabavan, Katrina Chau, Jennifer Q. J. Zhang, Benjamin S. Rayner, Gopala K. Rangan, Aarya Raghubanshi, Alexandra Munt, Yunjia Zhang, Annette T. Y. Wong
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0248400 (2021)
PLoS ONE
PLoS ONE
Augmentation of endogenous nitric oxide (NO) synthesis, either by the classical L-arginine-NO synthase pathway, or the recently discovered entero-salivary nitrate-nitrite-NO system, may slow the progression of autosomal dominant polycystic kidney dis
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218543 (2019)
PLoS ONE
PLoS ONE
Spirulina platensis is a blue-green algae with potential anti-obesity effects. In this study, the anti-obesity effects of whole Spirulina platensis (WSP), Spirulina platensis protein (SPP) and Spirulina platensis protein hydrolysate (SPPH) were compa