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Autor:
Christopher A. Smith, Paul A. Humphreys, Mark A. Naven, Steven Woods, Fabrizio E. Mancini, Julieta O’Flaherty, Qing-Jun Meng, Susan J. Kimber
Publikováno v:
Smith, C A, Humphreys, P A, Naven, M A, Woods, S, Mancini, F E, O'Flaherty, J, Meng, Q-J & Kimber, S J 2023, ' Directed differentiation of hPSCs through a simplified lateral plate mesoderm protocol for generation of articular cartilage progenitors ', PLoS ONE, vol. 18, no. 1, e0280024 . https://doi.org/10.1371/journal.pone.0280024
Developmentally, the articular joints are derived from lateral plate (LP) mesoderm. However, no study has produced both LP derived prechondrocytes and preosteoblasts from human pluripotent stem cells (hPSC) through a common progenitor in a chemically
Autor:
May Nak Lau, Wijenthiran Kunasekaran, Yue Yuan On, Li Jin Tan, Nurshafiqah Athirah Zaharin, Sarah H. A. Ghani, Sabri Musa, Roziana M. Razi, Gokula Mohan
The objective of this study was to compare the characteristics of Dental Pulp Stem Cells (DPSCs) derived from healthy human permanent teeth with those that were orthodontically-intruded to serve as potential Mesenchymal Stem Cells (MSC). Recruited su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb7254142dcaed5c1c28e75bdff6b22
https://www.repository.cam.ac.uk/handle/1810/344864
https://www.repository.cam.ac.uk/handle/1810/344864
Autor:
Jianghong Cheng, Jia Liang, Yingzhe Li, Xia Gao, Mengjun Ji, Mengying Liu, Yingpu Tian, Gensheng Feng, Wenbo Deng, Haibin Wang, Shuangbo Kong, Zhongxian Lu
Publikováno v:
PLoS Genetics, Vol 18, Iss 1, p e1010018 (2022)
PLoS Genetics
PLoS Genetics
Approximately 75% of failed pregnancies are considered to be due to embryo implantation failure or defects. Nevertheless, the explicit signaling mechanisms governing this process have not yet been elucidated. Here, we found that conditional deletion
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1009600 (2021)
PLoS Pathogens
PLoS Pathogens
Kaposi’s sarcoma (KS) is an angioproliferative and invasive tumor caused by Kaposi’s sarcoma-associated herpesvirus (KSHV). The cellular origin of KS tumor cells remains contentious. Recently, evidence has accrued indicating that KS may arise fro
Autor:
Makoto Ohashi, Nicholas P. Pauly, Kathleen R. Makielski, Shannon C. Kenney, Paul F. Lambert, Sai Wah Tsao, Denis Lee, Nicholas Van Sciver, Dhananjay M. Nawandar, Eric Johannsen, Jillian A. Bristol
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 11, p e1010045 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 11, p e1010045 (2021)
Epstein-Barr virus (EBV) is a human herpesvirus that causes infectious mononucleosis and contributes to both B-cell and epithelial-cell malignancies. EBV-infected epithelial cell tumors, including nasopharyngeal carcinoma (NPC), are largely composed
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11, p e1009579 (2021)
PLoS Computational Biology
PLoS Computational Biology
Organisms are composed of various cell types with specific states. To obtain a comprehensive understanding of the functions of organs and tissues, cell types have been classified and defined by identifying specific marker genes. Statistical tests are
Autor:
Hannah J Perrin, Swarooparani Vadlamudi, Kevin W Currin, Karen L. Mohlke, Gautam Kumar Pandey, Markku Laakso, Michael I. Love, Kenneth K Ng, Martin Wabitsch
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009865 (2021)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 10 (2021)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 10 (2021)
Chromatin accessibility and gene expression in relevant cell contexts can guide identification of regulatory elements and mechanisms at genome-wide association study (GWAS) loci. To identify regulatory elements that display differential activity acro
Autor:
Nakanoh, Shota, Kadiwala, Juned, Pinte, Laetitia, Morell, Carola Maria, Lenaerts, An-Sofie, Vallier, Ludovic
Publikováno v:
PLOS ONE. 17:e0269122
Acknowledgements: We thank Stephany Brown for the technical supports, Dr. Toshihiko Fujimori for discussion and Fatima Lugtu for English proofreading.
Funder: European Research Council
Funder: Cambridge Hospitals National Institute for Heal
Funder: European Research Council
Funder: Cambridge Hospitals National Institute for Heal
Autor:
Hiraku Tsujimoto, Naoko Katagiri, Yoshihiro Ijiri, Ben Sasaki, Yoshifumi Kobayashi, Akira Mima, Makoto Ryosaka, Kenichiro Furuyama, Yoshiya Kawaguchi, Kenji Osafune
Publikováno v:
PLOS ONE. 17:e0275600
Cell therapies using human induced pluripotent stem cell (hiPSC)-derived nephron progenitor cells (NPCs) are expected to ameliorate acute kidney injury (AKI). However, using hiPSC-derived NPCs clinically is a challenge because hiPSCs themselves are t
Autor:
Matthieu Valet, Patrick Narbonne
Publikováno v:
PLOS Genetics. 18:e1010434
Within living organisms, stem cells respond to various cues, including to niche signals and growth factors. Niche signals originate from the stem cell’s microenvironment and promote the undifferentiated state by preventing differentiation, allowing