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Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009041 (2020)
PLoS Genetics
PLoS Genetics
Through transfection of short single-stranded oligodeoxyribonucleotides (ssODNs) small genomic alterations can be introduced into mammalian cells with high precision. ssODNs integrate into the genome during DNA replication, but the resulting heterodu
Autor:
Yoshifumi Iwahashi, Masaru Nishino, Fidele Y. Musangile, Shin-ichi Murata, Kenji Warigaya, Fumiyoshi Kojima, Yuichi Takahashi, Yuichi Kinoshita, Ibu Matsuzaki
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236373 (2020)
PLoS ONE
PLoS ONE
The diagnosis of patients with malignancies relies on the results of a clinical cytological examination. To enhance the diagnostic qualities of cytological examinations, it is important to have a detailed analysis of the cell's characteristics. There
Autor:
Adele Khavari, Allen J. Ehrlicher
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221753 (2019)
PLoS ONE
PLoS ONE
Measuring pressures within complex multi-cellular environments is critical for studying mechanobiology as these forces trigger diverse biological responses, however, these studies are difficult as a deeply embedded yet well-calibrated probe is requir
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219078 (2019)
PLoS ONE
PLoS ONE
This study compared the relative cellular uptake of 80 nm silver nanoparticles (AgNP) with four different coatings including: branched polyethyleneimine (bPEI), citrate (CIT), polyvinylpyrrolidone (PVP), and polyethylene glycol (PEG). A gold nanopart
Autor:
Biljana Stojković, Marcos Gouveia, Špela Zemljič Jokhadar, Rui D. M. Travasso, Tjaša Sorčan, Mirjana Liovic, Marko Vidak, Jure Derganc
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0231606 (2020)
PLoS ONE
PLoS ONE
Keratin intermediate filaments are the principal structural element of epithelial cells. Their importance in providing bulk cellular stiffness is well recognized, but their role in the mechanics of cell cortex is less understood. In this study, we th
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237328 (2020)
PLoS ONE
PLoS ONE, Public Library of Science, 2020, ⟨10.1371/journal.pone.0237328⟩
PLoS ONE, 2020, ⟨10.1371/journal.pone.0237328⟩
PLoS ONE
PLoS ONE, Public Library of Science, 2020, ⟨10.1371/journal.pone.0237328⟩
PLoS ONE, 2020, ⟨10.1371/journal.pone.0237328⟩
International audience; α-Synuclein (αSyn) fibrils spread from one neuronal cell to another. This prion-like phenomenon is believed to contribute to the progression of the pathology in Parkinson's disease and other synucleinopathies. The binding of
Autor:
Hideaki Yoshida, Tomoko Haba, Shigeru Iida, Seiji Saito, Keiko Hiraishi, Nobuaki Takahashi, Hiroshi Namisaki, Yoshitaka Tanaka
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0229027 (2020)
PLoS ONE, Vol 15, Iss 3, p e0229027 (2020)
Human immunoglobulin G isotype 4 (IgG4) antibodies are suitable for use in either the antagonist or agonist format because their low effector functions prevent target cytotoxicity or unwanted cytokine secretion. However, while manufacturing therapeut
Autor:
Toni Montonen, Viviana P. Ribeiro, Anirban Roy, Sandra Pina, Joana Silva-Correia, Ana Oliveira, Jari Hyttinen, Cristiana Gonçalves, Hajer Radhouani, Joaquim M. Oliveira, Rui L. Reis
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194441 (2018)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS ONE
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS ONE
Timely and spatially-regulated injectable hydrogels, able to suppress growing tumors in response to conformational transitions of proteins, are of great interest in cancer research and treatment. Herein, we report rapidly responsive silk fibroin (SF)
Autor:
Florian Rüker, Mathias Gotsmy, Gordana Wozniak-Knopp, Jan Walther Perthold, Katharina Stadlbauer, Gerhard Stadlmayr, Stefan Becker
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195442 (2018)
PLoS ONE
PLoS ONE
We have designed a complete antibody-like construct where the CH1 and Cκ domains are exchanged for a pair of the CH3 domains and efficient pairing of the heavy and light variable domain is achieved using “Knobs-into-Holes” strategy. This constru
Autor:
Peter B. Dervan, Nathanael Kane, Nicholas G. Nickols, Nicolas Kummer, Silvia Diaz-Perez, Fei Yang, Alexis A. Kurmis
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196803 (2018)
PLoS ONE
PloS one, vol 13, iss 5
PLoS ONE
PloS one, vol 13, iss 5
Pyrrole-imidazole (Py-Im) polyamides are synthetic non-genotoxic minor groove-binding small molecules. We hypothesized that Py-Im polyamides can modulate the cellular response to ionizing radiation. Pre-treatment of cells with a Py-Im polyamide prior