Zobrazeno 1 - 10
of 695
pro vyhledávání: '"11"'
Autor:
Eliza Kwiatkowska-Borowczyk, Anna Kowalik, Andrzej Marszałek, Hanna Dams-Kozlowska, Andrzej Mackiewicz, Sebastian Adamczyk, Ewa Leporowska, Anna Lewandowska, Katarzyna Gryska
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154520 (2016)
PLoS ONE
PLoS ONE
The incidence of cancer is constantly increasing. Chemo/radiotherapy is one of major methods of treating cancer. Although adverse chemo/radiotherapy events, such as anemia and neutropenia, can be successfully cured, thrombocytopenia is still problema
Autor:
Si Jian Lin, Shi Yao Wen, Jiang Hua Dai, Fen Fen Yao, Yi Cheng Zhou, Rong Ping Zhou, Wen Bing Wan, Hui Bing Ruan, Jun Luo, Jin Xu, Hui Ling Zuo, Mei Lan Zhu, Wei Song
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0166751 (2016)
PLoS ONE
PLoS ONE
Cortex Eucommiae is used worldwide in traditional medicine, various constituents of Cortex Eucommiae, such as chlorogenic acid (CGA), has been reported to exert anti-osteoporosis activity in China, but the mechanism about their contribution to the ov
Autor:
Brian Y. Lee, Paul Timpson, Anita Ledger, Andrew M. K. Law, Andrew R. Green, Robert Salomon, Samantha R. Oakes, Matthew J. Naylor, Fatima Valdes-Mora, Ewan K.A. Millar, Alexander Swarbrick, C. Marcelo Sergio, Zoya Kikhtyak, Brian Rabinovich, Catherine L. Piggin, Christina Cho, Adelaide I. J. Young, Sandra A O'Toole, Susan J. Clark, Warren Kaplan, Christopher J. Ormandy, Julia Margaret Wendy Gee, James R.W. Conway, Tatyana Chtanova, Astrid Magenau, Heather J. Lee, David Herrmann, David Gallego-Ortega, Ian O. Ellis, Daniel L. Roden, Stephanie L. Allerdice
Publikováno v:
PLoS Biology, Vol 13, Iss 12, p e1002330 (2015)
PLoS Biology
PLoS Biology
During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional determinant of tumor subt
Autor:
Valentina Federici, Cesare Peschle, Laura Fontana, Serena Giovinazzi, Doriana Fruci, Matteo Forloni, Micol E. Fiori, Renata Boldrini, Alberto Donfrancesco, Loredana Cifaldi, Sonia Albini, Patrizio Giacomini
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2236 (2008)
PLoS ONE
PLoS ONE
We identified a key oncogenic pathway underlying neuroblastoma progression: specifically, MYCN, expressed at elevated level, transactivates the miRNA 17-5p-92 cluster, which inhibits p21 and BIM translation by interaction with their mRNA 3' UTRs. Ove
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 10, Iss 5, p e1004364 (2014)
PLoS Genetics, Vol 10, Iss 5, p e1004364 (2014)
Loss of PTPN11/SHP2 in mice or in human metachondromatosis (MC) patients causes benign cartilage tumors on the bone surface (exostoses) and within bones (enchondromas). To elucidate the mechanisms underlying cartilage tumor formation, we investigated
Autor:
Nahoko Iwata, Sean C. Godar, Marco Bortolato, Todd E. Morgan, Rob McConnell, David A. Davis, Caleb E. Finch, Jean C. Shih, Constantinos Sioutas, Thomas Sander, Payam Pakbin, Kiros Berhane
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64128 (2013)
PLoS ONE
PLoS ONE
Emerging evidence suggests that excessive exposure to traffic-derived air pollution during pregnancy may increase the vulnerability to neurodevelopmental alterations that underlie a broad array of neuropsychiatric disorders. We present a mouse model
Publikováno v:
PloS one, vol 14, iss 11
PLoS ONE, Vol 14, Iss 11, p e0224497 (2019)
PLoS ONE
PLoS ONE, Vol 14, Iss 11, p e0224497 (2019)
PLoS ONE
The placenta is a dynamic organ which undergoes extensive remodeling throughout pregnancy to support, protect and nourish the developing fetus. Despite the importance of the placenta, very little is known about its gene expression beyond very early p
Autor:
Hector H. Garcia, Oscar H. Del Brutto
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009883 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
Neurocysticercosis (NCC), the infection of the nervous system by the cystic larvae of Taenia solium, is a highly pleomorphic disease because of differences in the number and anatomical location of lesions, the viability of parasites, and the severity
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009892 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009892 (2021)
Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and morbidity in sub-Saharan Africa. We hypothesised that recent findings of neurological features and parasite brain infiltration occurring at much e
Autor:
Przemyslaw Blyszczuk, Nazmi Krasniqi, Gabriela Kania, Beatrice Beck-Schimmer, Björn Müller-Edenborn, Urs Eriksson, Philipp Jakob, Elena Osto
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154699 (2016)
PLoS ONE
PLoS ONE, 11 (5)
PLoS ONE
PLoS ONE, 11 (5)
Rationale Perioperative myocardial ischemia is common in high-risk patients. The use of interventional revascularisation or even thrombolysis is limited in this patient subset due to exceedingly high bleeding risks. Blockade of voltage-gated sodium c