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Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009840 (2021)
bioRxiv
PLoS Pathogens
bioRxiv
PLoS Pathogens
COVID-19 vaccines based on the Spike protein of SARS-CoV-2 have been developed that appear to be largely successful in stopping infection. However, therapeutics that can help manage the disease are still required until immunity has been achieved glob
Autor:
Matthew T. Birnie, Alex Paterson, Diana A. Stavreva, YM Kershaw, Becky L. Conway-Campbell, Audrys G Pauza, Songjoon Baek, David Murphy, Mark F. Rogers, Benjamin P. Flynn, Sohyoung Kim, Gordon L. Hager, Stafford L. Lightman
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics
Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam
Autor:
Hilary Ranson, Gareth J Lycett, Linda Grigoraki, Ruth Cowlishaw, Tony Nolan, Martin J. Donnelly
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009556 (2021)
PLoS Genetics
PLoS Genetics
Insecticide resistance in Anopheles mosquitoes is a major obstacle in maintaining the momentum in reducing the malaria burden; mitigating strategies require improved understanding of the underlying mechanisms. Mutations in the target site of insectic
Autor:
Ndeye Marie Sene, Alioune Gaye, Diawo Diallo, Ibrahima Dia, Yamar Ba, El Hadji Malick Ngom, Mawlouth Diallo, Konstantinos Mavridis, John Vontas, Cheikh Tidiane Diagne, El Hadji Ndiaye
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009393 (2021)
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases
Aedes aegypti is the main epidemic vector of arboviruses in Africa. In Senegal, control activities are mainly limited to mitigation of epidemics, with limited information available for Ae. aegypti populations. A better understanding of the current Ae
Autor:
H. L. Lee, Rosilawati Rasli, Ruziyatul Aznieda Azmi, Mohd Zainuldin Taib, Nurulhusna Ab Hamid, Siti Futri Farahininajua Fikri, Nur Ayuni Nazarudin, Nazni Wasi Ahmad, Yoon Ling Cheong, Rusydi Najmuddin Norzali, Afiq Ahnaf Hafisool, Topek Omar, Khairul Asuad Muhamed, Nur Fadillah Hamdan, Harith Aswad Ismail, M. Khairuddin Che Ibrahim, Roziah Ali
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009205 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background In Malaysia, dengue remains a top priority disease and usage of insecticides is the main method for dengue vector control. Limited baseline insecticide resistance data in dengue hotspots has prompted us to conduct this study. The present s
Autor:
Montserrat Esteve, Joana Pérez de San Román, Felix Junyent, María J. Ramírez, Grasa Mm, Angelo Ledda, Francisco J. Gil-Bea, José Gulfo
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246930 (2021)
Universidad de Barcelona
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246930 (2021)
Corticosteroid-binding globulin (CBG) is the specific carrier of circulating glucocorticoids, but evidence suggests that it also plays an active role in modulating tissue glucocorticoid activity. CBG polymorphisms affecting its expression or affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa6b1310837c928c1c27d4dc46919cf
http://hdl.handle.net/2445/175036
http://hdl.handle.net/2445/175036
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009064 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Several issues have been identified with the current programs for the elimination of onchocerciasis that target only transmission by using mass drug administration (MDA) of the drug ivermectin. Alternative and/or complementary treatment regimens as p
Autor:
Guy Roger Ndong Atome, Sylvain Godreuil, Arsène Mabika Mabika, Jean Jules Tewa, Jean Constant Obague Mbeang, Paul Yannick Bitome Essono, Jean Ulrich Muandze Nzambe, Pierre Philippe Mbehang Nguema, François Bretagnolle, Richard Onanga
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0257994 (2021)
PLoS ONE
PLoS ONE
Data on the prevalence of antibiotic resistance in Enterobacteriaceae in African wildlife are still relatively limited. The aim of this study was to estimate the prevalence of phenotypic intrinsic and acquired antimicrobial resistance of enterobacter
Autor:
Rachel E. Carlisle, Sarah Liu, Ming Chan Zhang, Chao Lu, Jeffrey G. Dickhout, Andy Phan, Elise Brimble, Salwa Farooqi
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260519 (2021)
PLoS ONE
PLoS ONE
Endoplasmic reticulum (ER) stress is associated with acute kidney injury (AKI) caused by various mechanisms, including antibiotics, non-steroidal anti-inflammatory drugs, cisplatin, and radiocontrast. Tunicamycin (TM) is a nucleoside antibiotic that
Autor:
Qiuju Huang, Zhongqiu Liu, Xiaoxiao Qi, Yanmin Zhang, Linlin Lu, Jiahao Chen, Ying Wang, Jian-Hua Deng, Jiada Han, Dawei Wang, Feng Qian, Elaine Lai-Han Leung
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249276 (2021)
PLoS ONE
PLoS ONE
Aconitine (AC) is the primary bioactive and secondary metabolite alkaloidin of Aconitum species which is accounted for more than 60% of the total diester-diterpenoid alkaloids in Aconite. To evaluate the analgesic effects of AC, 4 different pain mode