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Autor:
H. L. Lee, Rosilawati Rasli, Ruziyatul Aznieda Azmi, Mohd Zainuldin Taib, Nurulhusna Ab Hamid, Siti Futri Farahininajua Fikri, Nur Ayuni Nazarudin, Nazni Wasi Ahmad, Yoon Ling Cheong, Rusydi Najmuddin Norzali, Afiq Ahnaf Hafisool, Topek Omar, Khairul Asuad Muhamed, Nur Fadillah Hamdan, Harith Aswad Ismail, M. Khairuddin Che Ibrahim, Roziah Ali
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009205 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background In Malaysia, dengue remains a top priority disease and usage of insecticides is the main method for dengue vector control. Limited baseline insecticide resistance data in dengue hotspots has prompted us to conduct this study. The present s
Autor:
Qiuju Huang, Zhongqiu Liu, Xiaoxiao Qi, Yanmin Zhang, Linlin Lu, Jiahao Chen, Ying Wang, Jian-Hua Deng, Jiada Han, Dawei Wang, Feng Qian, Elaine Lai-Han Leung
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249276 (2021)
PLoS ONE
PLoS ONE
Aconitine (AC) is the primary bioactive and secondary metabolite alkaloidin of Aconitum species which is accounted for more than 60% of the total diester-diterpenoid alkaloids in Aconite. To evaluate the analgesic effects of AC, 4 different pain mode
Autor:
Alison Pan, Susanne M. Steggerda, Tony T. Huang, Tracy Y. Wang, Weiqun Li, Natalija Sotirovska, Matt Gross, Francesco Parlati, Devansh Singh, Jason J. Chen, Ethan Emberley, Andrew Mackinnon, Rosalyn Dang
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259241 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
Dysregulated metabolism is a hallmark of cancer that manifests through alterations in bioenergetic and biosynthetic pathways to enable tumor cell proliferation and survival. Tumor cells exhibit high rates of glycolysis, a phenomenon known as the Warb
Autor:
Alfredo Q. Antoniazzi, Lady Katerine Serrano Mujica, Carolina dos Santos Amaral, Suzan Gonçalves Rosa, Cristina W. Nogueira, Valério M. Portela, William Schoenau, M. F. Fiorenza, Natalia P. Smirnova, Fabio V. Comim, Gabrielle Rebeca Everling Correa
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257418 (2021)
PLoS ONE
PLoS ONE
One of the major causes of early pregnancy loss is heat stress. In ruminants, interferon tau (IFNT) is the embryo signal to the mother. Once the interferon signaling pathway is activated, it drives gene expression for interferon-stimulated genes (ISG
Autor:
Ningyong Xu, Viktoriya Pastukh, Mikhail Alexeyev, Troy Stevens, Dhananjay T. Tambe, Linn Ayers
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250095 (2021)
PLoS ONE
PLoS ONE
Collective migration of endothelial cells is important for wound healing and angiogenesis. During such migration, each constituent endothelial cell coordinates its magnitude and direction of migration with its neighbors while retaining intercellular
Autor:
M. V. C. Pacheco, F.A.S. Silva, Sebastião de Campos Valadares Filho, G.A.P. Souza, L. A. Godoi, A. C. B. Menezes, Nathalia Veloso Trópia, J. P. Schoonmaker, Luciana Navajas Rennó, Mário Fonseca Paulino, P. Pucetti, B. C. Silva
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259414 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0259414 (2021)
PLoS ONE
An experiment was conducted to evaluate the feed intake, nutrient digestibility and selected rumen parameters in feedlot bulls fed diets containing different feed additives. Six rumen-cannulated Nellore bulls (age = 8 ± 1.0 months; initial BW = 225
Autor:
Nasrullah Jan, Arshad Khan, Hassan Shah, Safiullah Khan, Ahsan Ali, Asadullah Madni, Muhammad Abdur Rahim, Abdul Jabar
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258141 (2021)
PLoS ONE
PLoS ONE
The present study is associated with the development of proliposomes and liposomal derived gel for enhanced solubility and permeability of diacerein. Proliposomes were developed by thin film hydration method and converted into the liposomal derived g
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250126 (2021)
PLoS ONE
PLoS ONE
Amino acid metabolism plays an important role in controlling blood pressure by regulating the production of NO and ROS. The present study examined amino acid levels in the serum of Dahl SS rats and SS.13BN rats fed a low or high salt diet. We observe
Autor:
Mohamed A. Morsy, Anroop B. Nair, Nagaraja Sreeharsha, Mahesh Attimarad, Shery Jacob, Katharigatta N. Venugopala, Sumeet Gupta, Bandar E. Al-Dhubiab, Jigar Shah, Pottathil Shinu
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248857 (2021)
PLoS ONE
PLoS ONE
In situ gels have been extensively explored as ocular drug delivery system to enhance bioavailability and efficacy. The objective of present study was to design, formulate and evaluate ion-activated in situ gel to enhance the ocular penetration and t
Autor:
Swaha Satpathy, Arjun Patra, Bharti Ahirwar, Muhammad Delwar Hussain, Mohsin Kazi, Mohammed S. Aldughaim
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0240068 (2021)
PLoS ONE
PLoS ONE
Pueraria tuberosa (Roxb. ex Willd.) DC., known as Indian Kudzu belongs to family Fabaceae and it is solicited as “Rasayana” drugs in Ayurveda. In the present study, we analyzed the efficacy of an ethyl acetate fraction from the tuber extract of P