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Autor:
Zhuonan Zhuang, Xiu Zhang, Yunfei Wang, Yong’an Chen, Xiaolong Deng, Hua Feng, Xuetao Yu, Xiaoqiang Fan, Long Peng, Jie Shen, Haibin Zhao
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 2, p e0149028 (2016)
PLoS ONE, Vol 11, Iss 2, p e0149028 (2016)
Pancreatic cancer is an aggressive disease with dismal prognosis. It is of paramount importance to understand the underlying etiological mechanisms and identify novel, consistent, and easy-to-apply prognostic factors for precision therapy. TUSC3 (tum
Autor:
Kouji Matsushima, Yutaka Inagaki, Takao Sato, Ah-Mee Park, Tatsuki Itoh, Tatsuya Tsukui, Kyosuke Kanai, Moisés Selman, Osamu Yoshie
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 2, p e0148998 (2016)
PLoS ONE, Vol 11, Iss 2, p e0148998 (2016)
Heat shock protein 27 (HSP27) is a member of the small molecular weight HSP family. Upon treatment with transforming growth factor β1 (TGF-β1), we observed upregulation of HSP27 along with that of α-smooth muscle actin (α-SMA), a marker of myofib
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0147380 (2016)
PLoS ONE, Vol 11, Iss 1, p e0147380 (2016)
BACKGROUND:Histone deacetylase 2 (HDAC2) is a class I histone deacetylase family member that plays a critical role in suppressing inflammatory gene expression in the airways, lung parenchyma, and alveolar macrophages in patients with chronic obstruct
Autor:
Linda Koshy Vaidyan, Yuki Yasumoto, Yui Yamamoto, Yu Katsuyama, Masaki Ogata, Yoshiteru Kagawa, Hirofumi Miyazaki, Majid Ebrahimi, Michiyasu Suzuki, Yuji Owada, Hirokazu Sadahiro
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147717 (2016)
PLoS ONE
PLoS ONE
Cellular metabolic changes, especially to lipid metabolism, have recently been recognized as a hallmark of various cancer cells. However, little is known about the significance of cellular lipid metabolism in the regulation of biological activity of
Autor:
Keisuke Kawasaki, Tsuyoshi Hachiya, Takeshi Iwaya, Kohei Kume, Risaburo Akasaka, Yukito Abiko, Satoshi Nishizuka, Takayuki Matsumoto, Kei Sato, Koki Otsuka, Teppei Matsuo
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146275 (2016)
PLoS ONE
PLoS ONE
Background Circulating tumor DNA (ctDNA) carries information on tumor burden. However, the mutation spectrum is different among tumors. This study was designed to examine the utility of ctDNA for monitoring tumor burden based on an individual mutatio
Autor:
Mu Sheng Zeng, Lihua Xu, Ming Song, Tian Run Liu, Ze Dong Hu, An Kui Yang, Man Zhi Li, Ping Han, Fu Jin Chen, Li Juan Hu, Qian Zhong
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40704 (2012)
PLoS ONE
PLoS ONE
Background To investigate the expression and role of special AT-rich sequence-binding protein-2 (SATB2) in laryngeal squamous cell carcinoma (LSCC) tissue and cell line (HEp2), and to evaluate the clinical and prognostic significance of SATB2 protein
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31802 (2012)
PLoS ONE
PLoS ONE
Reelin (RELN), which is a glycoprotein secreted by Cajal-Retzius cells of the developing cerebral cortex, plays an important role in neuronal migration, but its role in cell migration and cancer metastasis is largely unclear. Here, we showed that cel
Autor:
Yongzhan Nie, Shanhong Tang, Jie Liu, Kaichun Wu, Zheng Chen, Jie Ding, Guanghui Xu, Rui Fan, Lin Xia, Jiang Jin, Rui Du, Qian Bi, Liucun Gao, Shuhui Liang, Yongquan Shi, Daiming Fan
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40169 (2012)
PLoS ONE
PLoS ONE
Background Studies have been shown that miR-125a plays an important role in carcinogenesis, however, the role of miR-125a in hepatocellular carcinoma (HCC) remains elusive. Methodology/Principal Real time-PCR (qRT-PCR) was performed to test the signi
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46670 (2012)
PLoS ONE
PLoS ONE
We investigated the expression status of periostin in breast cancer stem cells and its clinical implications in order to lay a foundation for managing breast cancer. CD44+/CD24−/line- tumor cells (CSC) from clinical specimens were sorted using flow
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49439 (2012)
PLoS One, 7, 11
PLoS One, 7
PLOS ONE, 7(11):e49439. Public Library of Science
PLoS ONE
PLoS One, 7, 11
PLoS One, 7
PLOS ONE, 7(11):e49439. Public Library of Science
PLoS ONE
Contains fulltext : 109333.pdf (Publisher’s version ) (Open Access) Tribbles homolog 3 (TRIB3) is a scaffold protein activated under hypoxic conditions and involved in several cell survival and proliferation pathways. Recently, we reported opposite