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Autor:
Agata Poniewierska-Baran, Wojciech Marlicz, Karolina Skonieczna-Żydecka, Mariusz Z. Ratajczak, Rafal Bartoszewski, Sylwia Rzeszotek, Teresa Starzyńska
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0189337 (2018)
PLoS ONE
PLoS ONE
Background Colorectal cancer (CRC) is a leading cause of death in the western world, and its incidence increases with patient age. It is also known that with age there occur changes in the levels of certain hormones, including an increase in the secr
Autor:
Luca Braglia, Andrea Mozzarelli, Sally Maramotti, Stefania Croci, Alessandra Bisagni, F. Zanelli, Maria Pagano, Elena Tagliavini, Massimiliano Paci, Martina Bonacini
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196350 (2018)
PLoS ONE
PLoS ONE
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (gefitinib, erlotinib and afatinib) are indicated as first-line therapy in patients with non-small cell lung cancer (NSCLC) whose tumors harbor activating mutations in the EGFR gene.
Autor:
Jennifer Vogt, Jacqueline M. Tarrant, Priti S. Hegde, Annette T. Byrne, Monika A. Jarzabek, William R Proctor, Rajiv Raja, Jens Brodbeck, John W.M. Martens, Eric P. van der Stok, Cornelis Verhoef, Patrick Dicker, Rupal Desai, Dale Stevens, Gary Cain
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198099 (2018)
PLoS ONE
PLoS One (online), 13(6):e0198099. Public Library of Science
PLoS ONE
PLoS One (online), 13(6):e0198099. Public Library of Science
Drug-related sinusoidal dilatation (SD) is a common form of hepatotoxicity associated with oxaliplatin-based chemotherapy used prior to resection of colorectal liver metastases (CRLM). Recently, hepatic SD has also been associated with anti-delta lik
Autor:
Fadi Brimo, Miguel M. Burnier, Ana Beatriz Toledo Dias, Shraddha Solanki, Madhuri Koti, D. Robert Siemens, Jose Joao Mansure, Alice Yu, Wassim Kassouf
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205746 (2018)
PLoS ONE
PLoS ONE
Tumor-Infiltrating Lymphocytes (TILs) has been shown to be essential to predict disease outcome in several types of cancers. Moreover, the distribution of cytotoxic T lymphocytes (CD8+) and T cells in general (CD3+) have been used to establish an Imm
Autor:
Quentin Loyd, Liza J. Burton, Robin Roberts, Andrew Gacii, Maxine Harlemon, Nathan J. Bowen, Valerie Odero-Marah, Camille Ragin, Veronica Henderson, Ohuod Hawsawi, Simone M. Howard
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203855 (2018)
PLoS ONE
PLoS ONE
African Americans (AA) have higher death rates due to prostate and breast cancer as compared to Caucasian Americans (CA), and few biomarkers have been associated with this disparity. In our study we investigated whether epithelial-mesenchymal transit
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205846 (2018)
PLoS ONE
PLoS ONE
Introduction Among clinical challenges regarding human meningiomas is their propensity to recur even in cases with benign histology. Reliable biomarkers that can identify these cases are therefore highly desired. ErbB2/HER2 status is important in the
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205536 (2018)
PLoS ONE
PLoS ONE
Background Aldehyde dehydrogenase 1A1 (ALDH1A1) encodes an enzyme that oxidizes aldehydes to their corresponding carboxylic acids. In colorectal cancer ALDH1A1 marks cancer stem cells and plays putative roles in tumor progression and drug resistance.
Autor:
Narasimha Reddy Parine, Abdulrahman M Aljebreen, Maha Arafa, Ghadah Alamro, Ftoon Aljarbou, Sooad Al-Daihan, Nourah Almousa, Mohammed M. Alanazi, Abeer Al-Dbass, Shaheerah Alasirri, Arjumand S. Warsy, Abdullah Al-Amri, Othman Alharbi, Mohammad D. Bazzi, Nahla Azzam, Majid A Almadi, Jilani P. Shaik
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197154 (2018)
PLoS ONE
PLoS ONE
Background Colorectal cancer is the leading cause of cancer-related deaths in Saudi Arabia. Cancer has a multifactorial nature and can be described as a disease of altered gene expression. The profiling of gene expression has been used to identify ca
Autor:
Eran Sadot, T. Peter Kingham, Michael I. D’Angelica, Peter J. Allen, Andrea Ventura, Ronald P. DeMatteo, David S. Klimstra, Jian Zheng, William R. Jarnagin, Joana A. Vigidal, Vinod P. Balachandran
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200776 (2018)
PLoS ONE
PLoS ONE
Background Hepatocellular adenomas (HCA) are benign liver tumors that may transform into hepatocellular carcinoma (HCC), but the molecular drivers of this transformation remain ill-defined. This study evaluates the molecular changes in HCA and HCC an
Autor:
Susanta Roychoudhury, Supratim Ghosh, Shreya Sarkar, Chinmay Kumar Panda, Syam Sundar Mandal, Neyaz Alam, Kabita Chatterjee
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195937 (2018)
PLoS ONE
PLoS ONE
Head and neck squamous cell carcinoma (HNSCC) is a global disease and mortality burden, necessitating the elucidation of its molecular progression for effective disease management. The study aims to understand the molecular profile of three candidate