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Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178703 (2017)
PLoS ONE
PLoS ONE
Background Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis and the number of PDAC-related deaths is rising. Recently the tumour stroma and in particular one of its main components, hyaluronan (HA), have attracted considerable attention
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187635 (2017)
PLoS ONE
PLoS ONE
Invasion and metastasis are direct causes of mortality in patients with breast cancer and require reciprocal interactions between cancer cells and the extracellular matrix (ECM). Periostin, a fasciclin-containing adhesive ECM glycoprotein, is frequen
Autor:
Xin Zhang, Jiachun Lu, Lei Yang, Xiaoxiao Lu, Di Wu, Xiaoxuan Ling, Qingqing Nong, Fuman Qiu, Wenxiang Fang, Lisha Zhang, Binyao Yang, Xiaoliang Chen, Yifeng Zhou, Yongfang Wei, Jiansong Chen
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005955 (2016)
PLoS Genetics
PLoS Genetics
Accumulated evidence indicates that rare variants exert a vital role on predisposition and progression of human diseases, which provides neoteric insights into disease etiology. In the current study, based on three independently retrospective studies
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154739 (2016)
PLoS ONE
PLoS ONE
Purpose To analyze the clinical features and prognostic factors associated with the survival of patients with a very rare occurrence of brain metastasis (BM) from differentiated thyroid cancer (DTC). Methods and Materials A total of 37 patients with
Autor:
Sverre H. Torp, Theo L. Winther
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185217 (2017)
PLoS ONE
PLoS ONE
Background The 2016 WHO histopathological grading includes a substantial within-variation in recurrence risk, and is thus insufficient to predict prognosis after initial surgery of patients suffering from meningiomas. The aim of this study was to com
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126875 (2015)
PLoS ONE
PLoS ONE
Cyclin B1, a mitotic cyclin, has been implicated in malignances. However, its contribution to colorectal cancer invasion and metastasis are still not well understood. Here, we demonstrated that the invasion and metastasis of colorectal cancer is regu
Autor:
Feng Hong, Yanling Liang, Xinying Wang, Zhiqing Wang, Liang Peng, Kequan Chen, Shasha Su, Cassie Chang, Bo Jiang, Haitao Qin, Huabao Xiong, Zhongqiu Wang, Yan Liang, Wei Gong, Jieqiong Zhou, Weihua Han
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143513 (2015)
PLoS ONE
PLoS ONE
Objective Leucine-rich-repeat-containing G-protein-coupled receptor 5 (lgr5) is a candidate marker for colorectal cancer stem cells (CSC). In the current study, we investigated the methylation status within thelgr5 promoter and evaluated its relation
Autor:
Jie Chen, Qing Lv, Lijuan Yin, Yanping Wang, Yan Qiu, Xiao Rong Zhong, Hong Zheng, Ling Deng, Hui Fen Huang, Hong Bu, Ting Luo
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120511 (2015)
PLoS ONE
PLoS ONE
Background Abnormal activation of PI3K/AKT/mTOR (PAM) pathway, caused by PIK3CA mutation, KRAS mutation, PTEN loss, or AKT1 mutation, is one of the most frequent signaling abnormalities in breast carcinoma. However, distribution and frequencies of mu
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125976 (2015)
PLoS ONE
PLoS ONE
Oral squamous cell carcinoma (OSCC) comprises a subset of head and neck squamous cell carcinoma (HNSCC) with poor therapeutic outcomes and high glycolytic dependency. Neoadjuvant chemotherapy regimens of docetaxel, cisplatin and 5-fluorouracil (TPF)
Autor:
Masakazu Yashiro, Go Masuda, Tsuyoshi Hasegawa, Tamami Morisaki, Hiroaki Kasashima, Masaichi Ohira, Hirohisa Nakamae, Haruhito Kinoshita, Masayuki Hino, Tatsunari Fukuoka, Takahiko Nakane, Kosei Hirakawa
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178635 (2017)
PLoS ONE
PLoS ONE
Purpose It was reported that the chemokine (C-X-C motif) ligand 1 (CXCL1) from cancer cells stimulated the recruitment of bone marrow-derived mesenchymal cells (BM-MCs) into tumor stroma via chemokine (C-X-C motif) receptor 2 (CXCR2) signaling. We co