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pro vyhledávání: '"David Lyden"'
Autor:
Kevin C. De Braganca, Jill M. Kolesar, Yasmin Khakoo, Tanya M. Trippett, Kim Kramer, Shakeel Modak, Stephen Gilheeney, Brian H. Kushner, Oren J. Becher, Jason T. Huse, Nai-Kong V. Cheung, David Lyden, Nathan E. Millard, Sofia Haque, Ira J. Dunkel, Ivan Spasojevic
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178593 (2017)
PLoS ONE
PLoS ONE
The PI3K/Akt/mTOR signaling pathway is aberrantly activated in various pediatric tumors. We conducted a phase I study of the Akt inhibitor perifosine in patients with recurrent/refractory pediatric CNS and solid tumors. This was a standard 3+3 open-l