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Autor:
Guido E. Moro, Alessandra Coscia, Enrico Bertino, Stefano Sottemano, Manuela Donalisio, Giulia Maiocco, Federica Capitani, Andrea Civra, Paola Tonetto, David Lembo, Rachele Francese, Nicola Volpi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008713 (2020)
PLOS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
The benefits of human milk are mediated by multiple nutritional, trophic, and immunological components, able to promote infant’s growth, maturation of its immature gut, and to confer protection against infections. Despite these widely recognized pr
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1009007 (2020)
PLoS Pathogens
PLoS Pathogens
All symptoms of malaria disease are associated with the asexual blood stages of development, involving cycles of red blood cell (RBC) invasion and egress by the Plasmodium spp. merozoite. Merozoite invasion is rapid and is actively powered by a paras
Autor:
Vish Nene, Claudia Daubenberger, Richard P. Bishop, Roger Pelle, Kyle Tretina, Joana C. Silva, James B. Munro, Donald P. Knowles, Luke J. Tallon, W. Ivan Morrison, Jonathan Crabtree, Elliott F. Drabek, Hanzel T. Gotia, Elias Awino, Olukemi O. Ifeonu, Nicholas C. Palmateer, Joshua Orvis
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008781 (2020)
Palmateer, N C, Tretina, K, Orvis, J, Ifeonu, O O, Crabtree, J, Drabék, E, Pelle, R, Awino, E, Gotia, H T, Munro, J B, Tallon, L, Morrison, W I, Daubenberger, C A, Nene, V, Knowles, D P, Bishop, R P & Silva, J C 2020, ' Capture-based enrichment of Theileria parva DNA enables full genome assembly of first buffalo-derived strain and reveals exceptional intra-specific genetic diversity ', PLoS Neglected Tropical Diseases, vol. 14, no. 10, pp. e0008781 . https://doi.org/10.1371/journal.pntd.0008781
PLoS Neglected Tropical Diseases
Palmateer, N C, Tretina, K, Orvis, J, Ifeonu, O O, Crabtree, J, Drabék, E, Pelle, R, Awino, E, Gotia, H T, Munro, J B, Tallon, L, Morrison, W I, Daubenberger, C A, Nene, V, Knowles, D P, Bishop, R P & Silva, J C 2020, ' Capture-based enrichment of Theileria parva DNA enables full genome assembly of first buffalo-derived strain and reveals exceptional intra-specific genetic diversity ', PLoS Neglected Tropical Diseases, vol. 14, no. 10, pp. e0008781 . https://doi.org/10.1371/journal.pntd.0008781
PLoS Neglected Tropical Diseases
Theileria parva is an economically important, intracellular, tick-transmitted parasite of cattle. A live vaccine against the parasite is effective against challenge from cattle-transmissible T. parva but not against genotypes originating from the Afr
Autor:
Fawn B. Whittle, David J. Pintel, Trupti Joshi, Matthew S. Fuller, Kinjal Majumder, Juexin Wang, Maria Boftsi
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1009002 (2020)
PLoS Pathogens
PLoS Pathogens
The autonomous parvovirus Minute Virus of Mice (MVM) localizes to cellular DNA damage sites to establish and sustain viral replication centers, which can be visualized by focal deposition of the essential MVM non-structural phosphoprotein NS1. How su
Autor:
Mohammad R. Seyedsayamdost, Zemer Gitai, Chen Zhang, Geoffrey D. Vrla, Mark Esposito, Yibin Kang
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008867 (2020)
PLoS Pathogens
PLoS Pathogens
Surface attachment, an early step in the colonization of multiple host environments, activates the virulence of the human pathogen P. aeruginosa. However, the downstream toxins that mediate surface-dependent P. aeruginosa virulence remain unclear, as
Autor:
Kei Sato, Mahoko Takahashi Ueda, Keiya Uriu, Yusuke Kosugi, Reuben S. Harris, Yusuke Nakano, Yoshio Koyanagi, Shumpei Nagaoka, Hirofumi Aso, Keito Mitsumune, Yoriyuki Konno, Andrew Soper, Jumpei Ito, Naoko Misawa, So Nakagawa, Izumi Kimura, Terumasa Ikeda, Keisuke Yamamoto, Soma Shimizu, Guillermo Juarez-Fernandez, Ryuichi Kumata
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008812 (2020)
PLoS Pathogens
PLoS Pathogens
The APOBEC3 deaminases are potent inhibitors of virus replication and barriers to cross-species transmission. For simian immunodeficiency virus (SIV) to transmit to a new primate host, as happened multiple times to seed the ongoing HIV-1 epidemic, th
Autor:
Blandina T. Mmbaga, Gabriel M. Shirima, Matthew J. Denwood, Olubunmi Rhoda Aminu, Ruth N. Zadoks, Tiziana Lembo, Suzanna Lewis, Taya Forde, Roman Biek, Ireen Kiwelu, Deogratius Mshanga
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008655 (2020)
Aminu, O R, Lembo, T, Zadoks, R N, Biek, R, Lewis, S, Kiwelu, I, Mmbaga, B T, Mshanga, D, Shirima, G, Denwood, M & Forde, T L 2020, ' Practical and effective diagnosis of animal anthrax in endemic low-resource settings ', P L o S Neglected Tropical Diseases, vol. 14, no. 9, e0008655 . https://doi.org/10.1371/journal.pntd.0008655
PLoS Neglected Tropical Diseases
Aminu, O R, Lembo, T, Zadoks, R N, Biek, R, Lewis, S, Kiwelu, I, Mmbaga, B T, Mshanga, D, Shirima, G, Denwood, M & Forde, T L 2020, ' Practical and effective diagnosis of animal anthrax in endemic low-resource settings ', P L o S Neglected Tropical Diseases, vol. 14, no. 9, e0008655 . https://doi.org/10.1371/journal.pntd.0008655
PLoS Neglected Tropical Diseases
Anthrax threatens human and animal health, and people’s livelihoods in many rural communities in Africa and Asia. In these areas, anthrax surveillance is challenged by a lack of tools for on-site detection. Furthermore, cultural practices and infra
Autor:
David J. Sullivan, Jay Padalia, Laura Ann Leaton, Laura Farr, Shannon Moonah, Debbie-Ann Shirley, Swagata Ghosh, Aditya Singh
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008952 (2020)
PLoS Pathogens
PLoS Pathogens
Understanding how the protozoan protein degradation pathway is regulated could uncover new parasite biology for drug discovery. We found the COP9 signalosome (CSN) conserved in multiple pathogens such as Leishmania, Trypanosoma, Toxoplasma, and used
Autor:
Shiv D. Kale, Nuria Tubau-Juni, Josep Bassaganya-Riera, Raquel Hontecillas, Bridget Kastelberg, Austin Leung, Tariq Ayubi, Andrew Leber
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008854 (2020)
Aspergillus fumigatus is an opportunistic fungal pathogen of immunocompromised patient populations. Mortality is thought to be context-specific and occurs via both enhanced fungal growth and immunopathogenesis. NLRX1 is a negative regulator of immune
Autor:
Shunze Jia, Yan-Ting Liang, Yun Gao, Huabing Wang, Hideki Kawasaki, Yun-Cai Liu, Yu Tang, Yusong Xu
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1008980 (2020)
PLoS Genetics
PLoS Genetics
The complex stripes and patterns of insects play key roles in behavior and ecology. However, the fine-scale regulation mechanisms underlying pigment formation and morphological divergence remain largely unelucidated. Here we demonstrated that imagina