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Autor:
Newton G. Peres, Anna B. Erazo, Meghanashree M. Shreenivas, Sven Engel, Shaun R. McColl, Sammy Bedoui, Ian Comerford, Irmgard Förster, Paul G. Whitney, Dianna M Hocking, Stephen J. McSorley, Andreas Kupz, Thomas Gebhardt, Richard A. Strugnell, Nancy Wang
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1010004 (2021)
PLoS Pathogens
PLoS pathogens, vol 17, iss 10
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS Pathogens
PLoS pathogens, vol 17, iss 10
PLoS Pathogens, Vol 17, Iss 10 (2021)
While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD4+ T cells, identifying circulating protective cells has proved very difficult, inhibiting steps to identify key antigen
Autor:
Omar S. Akbari, Hideji Fujiwara, Damian Juncaj, Dihong Lu, Martin J. Boulanger, Susan Nguyen, Chaitra Bhat, Harpal Dhillon, Adler R. Dillman, Raghavendran Ramaswamy, Anna Buchman, Naoki Yamanaka, Shyon Nasrolahi, Sophia C. Parks
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1010027 (2021)
PLoS pathogens, vol 17, iss 10
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS pathogens, vol 17, iss 10
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10 (2021)
Parasitic nematodes cause significant morbidity and mortality globally. Excretory/secretory products (ESPs) such as fatty acid- and retinol- binding proteins (FARs) are hypothesized to suppress host immunity during nematode infection, yet little is k
Autor:
Hubertine M. E. Willems, Andrew C. Dixson, Glen E. Palmer, Junyan Liu, Stefanie Allert, Francisco N. Barrera, Brian M. Peters, Helene Tournu, Jonathan P. Richardson, Jian Miao, Christian DeJarnette, Bernhard Hube, David J. Lowes, Katherine S. Barker, Zhenbo Xu, Julian R. Naglik, Emily A. Sansevere
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009884 (2021)
PLoS Pathogens
PLoS Pathogens
Vulvovaginal candidiasis (VVC), caused primarily by the human fungal pathogen Candida albicans, results in significant quality-of-life issues for women worldwide. Candidalysin, a toxin derived from a polypeptide (Ece1p) encoded by the ECE1 gene, play
Autor:
Ingrid Alexandre de Abreu Brito, Tarcísio Fontenele de Brito, Mateus Berni, Maira Arruda Cardoso, Nicola Iovino, Attilio Pane, Fides Zenk, Vitor Lima Coelho
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009780 (2021)
PLoS Pathogens
PLoS Pathogens
Triatomine assassin bugs comprise hematophagous insect vectors of Trypanosoma cruzi, the causative agent of Chagas disease. Although the microbiome of these species has been investigated to some extent, only one virus infecting Triatoma infestans has
Autor:
Deanna L. Gibson, Joannie M. Allaire, Franziska A. Graef, Hyungjun Yang, Candice Quin, Martin Stahl, Kevan Jacobson, Else S. Bosman, Hongbing Yu, Elena F. Verdu, Justin Y.H. Chan, Mimi T. Y. Kuan, Bruce A. Vallance, Larissa Sbaglia Celiberto, Shauna M. Crowley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8 (2021)
PLoS Pathogens, Vol 17, Iss 8, p e1009719 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 8, p e1009719 (2021)
PLoS Pathogens
Reducing food intake is a common host response to infection, yet it remains unclear whether fasting is detrimental or beneficial to an infected host. Despite the gastrointestinal tract being the primary site of nutrient uptake and a common route for
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009699 (2021)
PLoS Pathogens
PLoS Pathogens
Globally, there are several million individuals with life-threatening invasive fungal diseases such as candidiasis, aspergillosis, cryptococcosis, Pneumocystis pneumonia (PCP), and mucormycosis. The mortality rate for these diseases generally exceeds
Autor:
Quynh Phung, Lorenzo Giacani, Nicole A P Lieberman, Alexander L. Greninger, Lauren C. Tantalo, Emily Romeis
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009612 (2021)
PLoS Pathogens
PLoS Pathogens
Despite more than a century of research, genetic manipulation of Treponema pallidum subsp. pallidum (T. pallidum), the causative agent of syphilis, has not been successful. The lack of genetic engineering tools has severely limited understanding of t
Autor:
André Alex Grassmann, Anthony A. Provatas, Melissa J. Caimano, Amit Luthra, Justin D. Radolf, Ashley M. Groshong, Melissa A. McLain
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009725 (2021)
PLoS Pathogens
PLoS Pathogens
In this study, we examined the relationship between c-di-GMP and its only known effector protein, PlzA, in Borrelia burgdorferi during the arthropod and mammalian phases of the enzootic cycle. Using a B. burgdorferi strain expressing a plzA point mut
Autor:
Cheng Peng, Xuzhuo Duan, Min Yang, Huitao Cheng, Shaowen Wang, Fengqi Huang, Qiwei Qin, Qing Wang, Huihong Zhao, Huirong Yang
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009665 (2021)
PLoS Pathogens
PLoS Pathogens
Viral nervous necrosis (VNN) is an acute and serious fish disease caused by nervous necrosis virus (NNV) which has been reported massive mortality in more than fifty teleost species worldwide. VNN causes damage of necrosis and vacuolation to central
Autor:
John D. Ventura, Abishek Chandrashekar, Peter Abbink, Noe B. Mercado, Rafael De La Barrera, Kenneth H. Eckels, Nelson L. Michael, Erica N. Borducchi, Michael P. Busch, Zhenfeng Li, Dan H. Barouch, Kayvon Modjarrad, Rafael A. Larocca
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009673 (2021)
PLoS Pathogens
PLoS Pathogens
Pre-existing immunity to flaviviruses can influence the outcome of subsequent flavivirus infections. Therefore, it is critical to determine whether baseline DENV immunity may influence subsequent ZIKV infection and the protective efficacy of ZIKV vac