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Autor:
Adriana Temporão, Terry K. Smith, Rafael Luis, Miguel Prudêncio, Margarida Sanches-Vaz, Luisa M. Figueiredo, Helena Nunes-Cabaço
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009912 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009912 (2021)
PLoS Neglected Tropical Diseases
© 2021 Temporão et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are
Autor:
Hubertine M. E. Willems, Andrew C. Dixson, Glen E. Palmer, Junyan Liu, Stefanie Allert, Francisco N. Barrera, Brian M. Peters, Helene Tournu, Jonathan P. Richardson, Jian Miao, Christian DeJarnette, Bernhard Hube, David J. Lowes, Katherine S. Barker, Zhenbo Xu, Julian R. Naglik, Emily A. Sansevere
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009884 (2021)
PLoS Pathogens
PLoS Pathogens
Vulvovaginal candidiasis (VVC), caused primarily by the human fungal pathogen Candida albicans, results in significant quality-of-life issues for women worldwide. Candidalysin, a toxin derived from a polypeptide (Ece1p) encoded by the ECE1 gene, play
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009699 (2021)
PLoS Pathogens
PLoS Pathogens
Globally, there are several million individuals with life-threatening invasive fungal diseases such as candidiasis, aspergillosis, cryptococcosis, Pneumocystis pneumonia (PCP), and mucormycosis. The mortality rate for these diseases generally exceeds
Autor:
Michiel Vanhooydonck, Geert Goeminne, Andreja Rajkovic, Lore Pottie, Wouter Van Gool, Bert Callewaert, Franz-Georg Hanisch, Paul Coucke, Patrick Sips
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009603 (2021)
PLOS GENETICS
PLoS Genetics
PLOS GENETICS
PLoS Genetics
The inability to maintain a strictly regulated endo(lyso)somal acidic pH through the proton-pumping action of the vacuolar-ATPases (v-ATPases) has been associated with various human diseases including heritable connective tissue disorders. Autosomal
Autor:
John D. Ventura, Abishek Chandrashekar, Peter Abbink, Noe B. Mercado, Rafael De La Barrera, Kenneth H. Eckels, Nelson L. Michael, Erica N. Borducchi, Michael P. Busch, Zhenfeng Li, Dan H. Barouch, Kayvon Modjarrad, Rafael A. Larocca
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009673 (2021)
PLoS Pathogens
PLoS Pathogens
Pre-existing immunity to flaviviruses can influence the outcome of subsequent flavivirus infections. Therefore, it is critical to determine whether baseline DENV immunity may influence subsequent ZIKV infection and the protective efficacy of ZIKV vac
Autor:
Peter Simmonds, M. Azim Ansari
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009596 (2021)
PLoS Pathogens
PLoS Pathogens
The rapid evolution of RNA viruses has been long considered to result from a combination of high copying error frequencies during RNA replication, short generation times and the consequent extensive fixation of neutral or adaptive changes over short
Autor:
Rohan Bhargava, Christine Pourciau, Tony Romeo, Autumn S. Dove, Daniel M. Czyż, Alfonso S. Vaziriyan-Sani, Emily T. Donahue, Michael J. Gebhardt, Alyssa C. Walker, Garrett L. Ellward
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009510 (2021)
PLoS Pathogens
PLoS Pathogens
Protein conformational diseases are characterized by misfolding and toxic aggregation of metastable proteins, often culminating in neurodegeneration. Enteric bacteria influence the pathogenesis of neurodegenerative diseases; however, the complexity o
Autor:
Brian J. Geiss, Gregory D. Ebel, Nicole R Sexton, Shijun Zhan, Savannah M. Rocha, Tawfik A. Aboellail, Rebekah C. Kading, Tony Schountz, Todd A. Bass, Juliette Lewis, Joel Rovnak, Olve B. Peersen, Bradly Burke, Anna C. Fagre, Ronald B. Tjalkens, Miles Eckley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009585 (2021)
PLoS Pathogens
PLoS Pathogens
Coronavirus disease-19 (COVID-19) emerged in late 2019 in China and rapidly became pandemic. As with other coronaviruses, a preponderance of evidence suggests the virus originated in horseshoe bats (Rhinolophus spp.) and may have infected an intermed
Autor:
Christiane Riedel, Bevan Sawatsky, Karl-Klaus Conzelmann, Anika Schopf, Martina Oberhuber, Kevin Wittwer, Rosalía Santos-Mandujano, Dominic H. Banda, Verena Pfaffinger, Alexandru A. Hennrich, Christian K. Pfaller
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009064 (2021)
PLoS pathogens, 17(4):e1009064
PLoS Pathogens
PLoS pathogens, 17(4):e1009064
PLoS Pathogens
Vaccines of outstanding efficiency, safety, and public acceptance are needed to halt the current SARS-CoV-2 pandemic. Concerns include potential side effects caused by the antigen itself and safety of viral DNA and RNA delivery vectors. The large SAR
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009535 (2021)
PLoS Genetics
PLoS Genetics
It has become increasingly clear that retrotransposons (RTEs) are more widely expressed in somatic tissues than previously appreciated. RTE expression has been implicated in a myriad of biological processes ranging from normal development and aging,