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Autor:
Madsen, Ralitsa R, Erickson, Emily C, Rueda Palacio, Oscar, Robin, Xavier, Caldas, Carlos, Toker, Alex, Semple, Robert K, Vanhaesebroeck, Bart
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009876 (2021)
PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics
Madsen, R R, Erickson, E C, Rueda, O M, Robin, X, Caldas, C, Toker, A, Semple, R K & Vanhaesebroeck, B 2021, ' Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1009876
PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics
Madsen, R R, Erickson, E C, Rueda, O M, Robin, X, Caldas, C, Toker, A, Semple, R K & Vanhaesebroeck, B 2021, ' Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1009876
Funder: pten research foundation
Funder: cancer research uk; funder-id: http://dx.doi.org/10.13039/501100000289
A PI3K��-selective inhibitor has recently been approved for use in breast tumors harboring mutations in PIK3CA, the gene enc
Funder: cancer research uk; funder-id: http://dx.doi.org/10.13039/501100000289
A PI3K��-selective inhibitor has recently been approved for use in breast tumors harboring mutations in PIK3CA, the gene enc
Autor:
Sivakanthan Kasinathan, Vivek Venkataramani, Pei Feng Cheng, Xiaoying Wu, Brian Freie, Patrick A. Carroll, Donald E. Ayer, Theresa Hedrich, Haiwei Gu, Vijay Ramani, Daniel Raftery, Charles H. Muller, Jay Shendure, James A. Dowdle, Robert N. Eisenman
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001085 (2021)
PLoS Biology
PLoS Biology
Male germ cell (GC) production is a metabolically driven and apoptosis-prone process. Here, we show that the glucose-sensing transcription factor (TF) MAX-Like protein X (MLX) and its binding partner MondoA are both required for male fertility in the
Autor:
Andrew Dhawan, Davis T. Weaver, Drew F. K. Williamson, Kathleen I. Pishas, Jacob G. Scott, Stephen L. Lessnick, Jessica A. Scarborough
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1008755 (2021)
PLoS Computational Biology
PLoS Computational Biology
MicroRNA (miRNA)-based therapies are an emerging class of targeted therapeutics with many potential applications. Ewing Sarcoma patients could benefit dramatically from personalized miRNA therapy due to inter-patient heterogeneity and a lack of drugg
Autor:
Euzenir Nunes Sarno, Andrej Benjak, Stewart T. Cole, Philippe Busso, Charlotte Avanzi, Thyago Leal-Calvo, Milton Ozório Moraes, Roberta Olmo Pinheiro, Mayara Abud Mendes
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009972 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009972 (2021)
Author summary
Despite effective treatment, leprosy is still a significant public health issue in more than 120 countries, with more than 200 000 new cases yearly. The disease is caused mainly by Mycobacterium leprae, a slow-growing bacillus sti
Despite effective treatment, leprosy is still a significant public health issue in more than 120 countries, with more than 200 000 new cases yearly. The disease is caused mainly by Mycobacterium leprae, a slow-growing bacillus sti
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1008874 (2021)
PLoS Computational Biology
PLoS Computational Biology
Respiratory viruses present major public health challenges, as evidenced by the 1918 Spanish Flu, the 1957 H2N2, 1968 H3N2, and 2009 H1N1 influenza pandemics, and the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Seve
Autor:
Makoto Ohashi, Nicholas P. Pauly, Jillian A. Bristol, Nicholas Van Sciver, Shannon C. Kenney, Scott E. Nelson, Eric Johannsen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009783 (2021)
PLoS Pathogens
PLoS Pathogens
The Epstein-Barr virus (EBV) human herpesvirus is associated with B-cell and epithelial-cell malignancies, and both the latent and lytic forms of viral infection contribute to the development of EBV-associated tumors. Here we show that the Hippo sign
Autor:
Pedro de Atauri, Josep Tarragó-Celada, Effrosyni Karakitsou, Marta Cascante, Carles Foguet, Míriam Tarrado-Castellarnau, Josep J. Centelles
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 7, p e1009234 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS Computational Biology, Vol 17, Iss 7, p e1009234 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
Metabolic adaptations to complex perturbations, like the response to pharmacological treatments in multifactorial diseases such as cancer, can be described through measurements of part of the fluxes and concentrations at the systemic level and indivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e997e2095349b1209609ba36d766280f
http://hdl.handle.net/2445/180774
http://hdl.handle.net/2445/180774
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001271 (2021)
PLoS Biology
PLoS Biology
Leukotriene B4 (LTB4) is secreted by chemotactic neutrophils, forming a secondary gradient that amplifies the reach of primary chemoattractants. This strategy increases the recruitment range for neutrophils and is important during inflammation. Here,
Autor:
Hyun-Min Kim, Sara E. Beese-Sims, Xiaojuan Zhang, Sisi Tian, Jingjie Chen, Nara Shin, Monica P. Colaiácovo
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009715 (2021)
PLoS Genetics
PLoS Genetics
Histone methylation is dynamically regulated to shape the epigenome and adjust central nuclear processes including transcription, cell cycle control and DNA repair. Lysine-specific histone demethylase 2 (LSD2) has been implicated in multiple types of
Autor:
Penelope A. Morel, Rosemary A. Aogo, Vivienne Crowe, Amber M. Smith, Morgan Craig, Amanda P. Smith, Xiaoyan Deng, Adrianne L. Jenner, Courtney L. Davis, Sofia Alfonso
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009753 (2021)
To understand the diversity of immune responses to SARS-CoV-2 and distinguish features that predispose individuals to severe COVID-19, we developed a mechanistic, within-host mathematical model and virtual patient cohort. Our results suggest that vir