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Autor:
Sivakanthan Kasinathan, Vivek Venkataramani, Pei Feng Cheng, Xiaoying Wu, Brian Freie, Patrick A. Carroll, Donald E. Ayer, Theresa Hedrich, Haiwei Gu, Vijay Ramani, Daniel Raftery, Charles H. Muller, Jay Shendure, James A. Dowdle, Robert N. Eisenman
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001085 (2021)
PLoS Biology
PLoS Biology
Male germ cell (GC) production is a metabolically driven and apoptosis-prone process. Here, we show that the glucose-sensing transcription factor (TF) MAX-Like protein X (MLX) and its binding partner MondoA are both required for male fertility in the
Autor:
Euzenir Nunes Sarno, Andrej Benjak, Stewart T. Cole, Philippe Busso, Charlotte Avanzi, Thyago Leal-Calvo, Milton Ozório Moraes, Roberta Olmo Pinheiro, Mayara Abud Mendes
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009972 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009972 (2021)
Author summary
Despite effective treatment, leprosy is still a significant public health issue in more than 120 countries, with more than 200 000 new cases yearly. The disease is caused mainly by Mycobacterium leprae, a slow-growing bacillus sti
Despite effective treatment, leprosy is still a significant public health issue in more than 120 countries, with more than 200 000 new cases yearly. The disease is caused mainly by Mycobacterium leprae, a slow-growing bacillus sti
Autor:
Makoto Ohashi, Nicholas P. Pauly, Jillian A. Bristol, Nicholas Van Sciver, Shannon C. Kenney, Scott E. Nelson, Eric Johannsen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009783 (2021)
PLoS Pathogens
PLoS Pathogens
The Epstein-Barr virus (EBV) human herpesvirus is associated with B-cell and epithelial-cell malignancies, and both the latent and lytic forms of viral infection contribute to the development of EBV-associated tumors. Here we show that the Hippo sign
Autor:
Hyun-Min Kim, Sara E. Beese-Sims, Xiaojuan Zhang, Sisi Tian, Jingjie Chen, Nara Shin, Monica P. Colaiácovo
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009715 (2021)
PLoS Genetics
PLoS Genetics
Histone methylation is dynamically regulated to shape the epigenome and adjust central nuclear processes including transcription, cell cycle control and DNA repair. Lysine-specific histone demethylase 2 (LSD2) has been implicated in multiple types of
Autor:
Edgar Kozlova, Bojan Losic, Johann von Felden, Swan N. Thung, Ismail Labgaa, Marina Ruiz de Galarreta, Sebastiao N. Martins-Filho, Teresa Garcia-Lezana, Erin Bresnahan, Amaia Lujambio, Carlos Villacorta-Martin, Daniela Sia, Amanda J. Craig, Myron Schwartz, Delia D'Avola, Gabriela Hernandez-Meza, Josep M. Llovet, Mehmet Eren Ahsen, Augusto Villanueva
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009589 (2021)
PLoS Genetics
PLoS Genetics
Cancer testis antigens (CTAs) are an extensive gene family with a unique expression pattern restricted to germ cells, but aberrantly reactivated in cancer tissues. Studies indicate that the expression (or re-expression) of CTAs within the MAGE-A fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1cfc57210ada270637321ca4b62142
http://hdl.handle.net/2445/194960
http://hdl.handle.net/2445/194960
Autor:
Fatemeh Mirzapourshafiyi, Yukinori Kametani, Masanori Nakayama, Takao Hikita, Yosuke Hasegawa
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1008398 (2021)
PLoS Computational Biology
PLoS Computational Biology
Blood flow governs transport of oxygen and nutrients into tissues. Hypoxic tissues secrete VEGFs to promote angiogenesis during development and in tissue homeostasis. In contrast, tumors enhance pathologic angiogenesis during growth and metastasis, s
Autor:
Michela Grillo, Natalia A. Riobo-Del Galdo, Robert E. Hill, Malgorzata Kubiak, David Mellis, Elaine Kinsella, Donald Salter, Ioanna Ch. Georgiou, Katherine Staines, Silvia Peluso, Rob van't Hof, Anna Thornburn, Natalie Dora, Stuart H. Ralston, Colin Farquharson, Mark Ditzel
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009275 (2021)
PLOS GENETICS
Mellis, D, Staines, K, Peluso, S, Georgiou, I C, Dora, N, Kubiak, M, van't Hof, R, Grillo, M, Farquharson, C, Kinsella, E, Thornburn, A, Ralston, S H, Salter, D M, Riobo-Del Galdo, N A, Hill, R E & Ditzel, M 2021, ' Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis. ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1009275
PLoS Genetics
PLOS GENETICS
Mellis, D, Staines, K, Peluso, S, Georgiou, I C, Dora, N, Kubiak, M, van't Hof, R, Grillo, M, Farquharson, C, Kinsella, E, Thornburn, A, Ralston, S H, Salter, D M, Riobo-Del Galdo, N A, Hill, R E & Ditzel, M 2021, ' Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis. ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1009275
PLoS Genetics
Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is the mammalian homologue of the E3 ubiquitin-protein ligase Hyd, a negative regulator of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a52668b3bca56103d39e02d6dfc082
https://eprints.whiterose.ac.uk/173526/1/journal.pgen.1009275.pdf
https://eprints.whiterose.ac.uk/173526/1/journal.pgen.1009275.pdf
Autor:
Ane Birgitte Telén Andersen, Reza Rafiolsadat Serizawa, Berit Andersen, Lise Grupe Larsen, Dorthe Ejersbo, Tonje Johansen, Hanne Nørgaard Heje, Petra Hall Viborg, Gry St-Martin, Marianne Waldstrøm, Kirsten Marie Jochumsen, Jette Christensen, Elsebeth Lynge
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246902 (2021)
St-Martin, G, Viborg, P H, Telén Andersen, A B, Andersen, B, Christensen, J, Ejersbo, D, Heje, H N, Jochumsen, K M, Johansen, T, Larsen, L G, Lynge, E, Serizawa, R R & Waldstrøm, M 2021, ' Histological outcomes in HPV-screened elderly women in Denmark ', PLoS ONE, vol. 16, e0246902 . https://doi.org/10.1371/journal.pone.0246902
St-Martin, G, Viborg, P H, Telén Andersen, A B, Andersen, B, Christensen, J, Ejersbo, D, Heje, H N, Jochumsen, K M, Johansen, T, Larsen, L G, Lynge, E, Serizawa, R R & Waldstrøm, M 2021, ' Histological outcomes in HPV-screened elderly women in Denmark ', PLOS ONE, vol. 16, no. 2, e0246902 . https://doi.org/10.1371/journal.pone.0246902
PLoS ONE
St-Martin, G, Viborg, P H, Andersen, A B T, Andersen, B, Christensen, J, Ejersbo, D, Heje, H N, Jochumsen, K M, Johansen, T, Larsen, L G, Lynge, E, Serizawa, R R & Waldstrøm, M 2021, ' Histological outcomes in HPV-screened elderly women in Denmark ', P L o S One, vol. 16, no. 2, 0246902 . https://doi.org/10.1371/journal.pone.0246902
St-Martin, G, Viborg, P H, Telén Andersen, A B, Andersen, B, Christensen, J, Ejersbo, D, Heje, H N, Jochumsen, K M, Johansen, T, Larsen, L G, Lynge, E, Serizawa, R R & Waldstrøm, M 2021, ' Histological outcomes in HPV-screened elderly women in Denmark ', PLoS ONE, vol. 16, e0246902 . https://doi.org/10.1371/journal.pone.0246902
St-Martin, G, Viborg, P H, Telén Andersen, A B, Andersen, B, Christensen, J, Ejersbo, D, Heje, H N, Jochumsen, K M, Johansen, T, Larsen, L G, Lynge, E, Serizawa, R R & Waldstrøm, M 2021, ' Histological outcomes in HPV-screened elderly women in Denmark ', PLOS ONE, vol. 16, no. 2, e0246902 . https://doi.org/10.1371/journal.pone.0246902
PLoS ONE
St-Martin, G, Viborg, P H, Andersen, A B T, Andersen, B, Christensen, J, Ejersbo, D, Heje, H N, Jochumsen, K M, Johansen, T, Larsen, L G, Lynge, E, Serizawa, R R & Waldstrøm, M 2021, ' Histological outcomes in HPV-screened elderly women in Denmark ', P L o S One, vol. 16, no. 2, 0246902 . https://doi.org/10.1371/journal.pone.0246902
Introduction Danish women exit cervical cancer screening at age 65 years, but 23% of cervical cancer cases occur beyond this age. In addition, due to gradual implementation of cervical cancer screening, older women are underscreened by today´s stand
Autor:
Bhavik Patel, Sara Bolivar-Wagers, Nami Iwamoto, Mario Roederer, Cristina Bergamaschi, Kaimei Song, George N. Pavlakis, Rosemarie D. Mason, Edward A. Berger
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248973 (2021)
PLoS ONE
PLoS ONE
Achieving a functional cure is an important goal in the development of HIV therapy. Eliciting HIV-specific cellular immune responses has not been sufficient to achieve durable removal of HIV-infected cells due to the restriction on effective immune r
Autor:
Anne Reynaud, Stéphanie Gachet, Claire Catherinet, C. Tran Quang, Hind Medyouf, Diana Passaro, Charlène Lasgi, Jacques Ghysdael
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254184 (2021)
PLoS ONE
PLoS ONE
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with few available targeted therapies. We previously reported that the phosphatase calcineurin (Cn) is required for LIC (leukemia Initiating Capacity) potential of T-ALL pointing