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Autor:
Madsen, Ralitsa R, Erickson, Emily C, Rueda Palacio, Oscar, Robin, Xavier, Caldas, Carlos, Toker, Alex, Semple, Robert K, Vanhaesebroeck, Bart
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009876 (2021)
PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics
Madsen, R R, Erickson, E C, Rueda, O M, Robin, X, Caldas, C, Toker, A, Semple, R K & Vanhaesebroeck, B 2021, ' Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1009876
PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics
Madsen, R R, Erickson, E C, Rueda, O M, Robin, X, Caldas, C, Toker, A, Semple, R K & Vanhaesebroeck, B 2021, ' Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1009876
Funder: pten research foundation
Funder: cancer research uk; funder-id: http://dx.doi.org/10.13039/501100000289
A PI3K��-selective inhibitor has recently been approved for use in breast tumors harboring mutations in PIK3CA, the gene enc
Funder: cancer research uk; funder-id: http://dx.doi.org/10.13039/501100000289
A PI3K��-selective inhibitor has recently been approved for use in breast tumors harboring mutations in PIK3CA, the gene enc
Autor:
Sivakanthan Kasinathan, Vivek Venkataramani, Pei Feng Cheng, Xiaoying Wu, Brian Freie, Patrick A. Carroll, Donald E. Ayer, Theresa Hedrich, Haiwei Gu, Vijay Ramani, Daniel Raftery, Charles H. Muller, Jay Shendure, James A. Dowdle, Robert N. Eisenman
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001085 (2021)
PLoS Biology
PLoS Biology
Male germ cell (GC) production is a metabolically driven and apoptosis-prone process. Here, we show that the glucose-sensing transcription factor (TF) MAX-Like protein X (MLX) and its binding partner MondoA are both required for male fertility in the
Autor:
Andrew Dhawan, Davis T. Weaver, Drew F. K. Williamson, Kathleen I. Pishas, Jacob G. Scott, Stephen L. Lessnick, Jessica A. Scarborough
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1008755 (2021)
PLoS Computational Biology
PLoS Computational Biology
MicroRNA (miRNA)-based therapies are an emerging class of targeted therapeutics with many potential applications. Ewing Sarcoma patients could benefit dramatically from personalized miRNA therapy due to inter-patient heterogeneity and a lack of drugg
Autor:
Euzenir Nunes Sarno, Andrej Benjak, Stewart T. Cole, Philippe Busso, Charlotte Avanzi, Thyago Leal-Calvo, Milton Ozório Moraes, Roberta Olmo Pinheiro, Mayara Abud Mendes
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009972 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009972 (2021)
Author summary
Despite effective treatment, leprosy is still a significant public health issue in more than 120 countries, with more than 200 000 new cases yearly. The disease is caused mainly by Mycobacterium leprae, a slow-growing bacillus sti
Despite effective treatment, leprosy is still a significant public health issue in more than 120 countries, with more than 200 000 new cases yearly. The disease is caused mainly by Mycobacterium leprae, a slow-growing bacillus sti
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1008874 (2021)
PLoS Computational Biology
PLoS Computational Biology
Respiratory viruses present major public health challenges, as evidenced by the 1918 Spanish Flu, the 1957 H2N2, 1968 H3N2, and 2009 H1N1 influenza pandemics, and the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Seve
Autor:
Makoto Ohashi, Nicholas P. Pauly, Jillian A. Bristol, Nicholas Van Sciver, Shannon C. Kenney, Scott E. Nelson, Eric Johannsen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009783 (2021)
PLoS Pathogens
PLoS Pathogens
The Epstein-Barr virus (EBV) human herpesvirus is associated with B-cell and epithelial-cell malignancies, and both the latent and lytic forms of viral infection contribute to the development of EBV-associated tumors. Here we show that the Hippo sign
Autor:
Edgar Kozlova, Bojan Losic, Johann von Felden, Swan N. Thung, Ismail Labgaa, Marina Ruiz de Galarreta, Sebastiao N. Martins-Filho, Teresa Garcia-Lezana, Erin Bresnahan, Amaia Lujambio, Carlos Villacorta-Martin, Daniela Sia, Amanda J. Craig, Myron Schwartz, Delia D'Avola, Gabriela Hernandez-Meza, Josep M. Llovet, Mehmet Eren Ahsen, Augusto Villanueva
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009589 (2021)
PLoS Genetics
PLoS Genetics
Cancer testis antigens (CTAs) are an extensive gene family with a unique expression pattern restricted to germ cells, but aberrantly reactivated in cancer tissues. Studies indicate that the expression (or re-expression) of CTAs within the MAGE-A fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1cfc57210ada270637321ca4b62142
http://hdl.handle.net/2445/194960
http://hdl.handle.net/2445/194960
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009670 (2021)
PLoS Pathogens
PLoS Pathogens
KDM4A is a histone lysine demethylase that has been described as an oncogene in various types of cancer. The importance of KDM4A-mediated epigenetic regulation in tumorigenesis is just emerging. Here, by using Kaposi’s sarcoma associated herpesviru
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008960 (2021)
PLoS Computational Biology
PLoS Computational Biology
A wide variety of 1) parametric regression models and 2) co-expression networks have been developed for finding gene-by-gene interactions underlying complex traits from expression data. While both methodological schemes have their own well-known bene
Autor:
Zaoke He, Tao Wu, Xiangyu Zhao, Huimin Li, Shixiang Wang, Ziyu Tao, Kai Wu, Minfang Song, Xue-Song Liu
Publikováno v:
PLoS Genetics, Vol 17, Iss 5, p e1009557 (2021)
PLoS Genetics
PLoS Genetics
Genome alteration signatures reflect recurring patterns caused by distinct endogenous or exogenous mutational events during the evolution of cancer. Signatures of single base substitution (SBS) have been extensively studied in different types of canc