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Autor:
Madsen, Ralitsa R, Erickson, Emily C, Rueda Palacio, Oscar, Robin, Xavier, Caldas, Carlos, Toker, Alex, Semple, Robert K, Vanhaesebroeck, Bart
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009876 (2021)
PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics
Madsen, R R, Erickson, E C, Rueda, O M, Robin, X, Caldas, C, Toker, A, Semple, R K & Vanhaesebroeck, B 2021, ' Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1009876
PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics
Madsen, R R, Erickson, E C, Rueda, O M, Robin, X, Caldas, C, Toker, A, Semple, R K & Vanhaesebroeck, B 2021, ' Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1009876
Funder: pten research foundation
Funder: cancer research uk; funder-id: http://dx.doi.org/10.13039/501100000289
A PI3K��-selective inhibitor has recently been approved for use in breast tumors harboring mutations in PIK3CA, the gene enc
Funder: cancer research uk; funder-id: http://dx.doi.org/10.13039/501100000289
A PI3K��-selective inhibitor has recently been approved for use in breast tumors harboring mutations in PIK3CA, the gene enc
Autor:
Andrew W. Murray, Marco Fumasoni
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 11, p e1009875 (2021)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 11, p e1009875 (2021)
In haploid budding yeast, evolutionary adaptation to constitutive DNA replication stress alters three genome maintenance modules: DNA replication, the DNA damage checkpoint, and sister chromatid cohesion. We asked how these trajectories depend on gen
Autor:
Chris Wallace
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009440 (2021)
PLoS Genetics
PLoS Genetics
In genome-wide association studies (GWAS) it is now common to search for, and find, multiple causal variants located in close proximity. It has also become standard to ask whether different traits share the same causal variants, but one of the popula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfbc0fd758d2e33cc583429e7183c180
Autor:
Hannah J Perrin, Swarooparani Vadlamudi, Kevin W Currin, Karen L. Mohlke, Gautam Kumar Pandey, Markku Laakso, Michael I. Love, Kenneth K Ng, Martin Wabitsch
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009865 (2021)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 10 (2021)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 10 (2021)
Chromatin accessibility and gene expression in relevant cell contexts can guide identification of regulatory elements and mechanisms at genome-wide association study (GWAS) loci. To identify regulatory elements that display differential activity acro
Autor:
Riga, Amalia, Cravo, Janine, Schmidt, Ruben, Pires, Helena R, Castiglioni, Victoria G, van den Heuvel, Sander, Boxem, Mike, Developmental Biology, Sub Developmental Biology
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009856 (2021)
PLoS Genetics, 17(10), 1. Public Library of Science
PLoS Genetics
PLoS Genetics, 17(10), 1. Public Library of Science
PLoS Genetics
The conserved adapter protein Scribble (Scrib) plays essential roles in a variety of cellular processes, including polarity establishment, proliferation, and directed cell migration. While the mechanisms through which Scrib promotes epithelial polari
Single-cell RNA-sequencing reveals pre-meiotic X-chromosome dosage compensation in Drosophila testis
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009728 (2021)
PLoS Genetics
PLoS Genetics
Dosage compensation equalizes X-linked expression between XY males and XX females. In male fruit flies, expression levels of the X-chromosome are increased approximately two-fold to compensate for their single X chromosome. In testis, dosage compensa
Autor:
Makoto Ohashi, Nicholas P. Pauly, Jillian A. Bristol, Nicholas Van Sciver, Shannon C. Kenney, Scott E. Nelson, Eric Johannsen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009783 (2021)
PLoS Pathogens
PLoS Pathogens
The Epstein-Barr virus (EBV) human herpesvirus is associated with B-cell and epithelial-cell malignancies, and both the latent and lytic forms of viral infection contribute to the development of EBV-associated tumors. Here we show that the Hippo sign
Autor:
Matthew T. Birnie, Alex Paterson, Diana A. Stavreva, YM Kershaw, Becky L. Conway-Campbell, Audrys G Pauza, Songjoon Baek, David Murphy, Mark F. Rogers, Benjamin P. Flynn, Sohyoung Kim, Gordon L. Hager, Stafford L. Lightman
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics
Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009529 (2021)
PLoS Genetics
PLoS Genetics
The Mediator coactivator complex is divided into four modules: head, middle, tail, and kinase. Deletion of the architectural subunit Med16 separates core Mediator (cMed), comprising the head, middle, and scaffold (Med14), from the tail. However, the
Autor:
Courtney N. Passow, Nicolas Rohner, James B. Jaggard, Katya L. Mack, Emma Y. Roback, Johanna E. Kowalko, Estephany Ferrufino, Alex C. Keene, Suzanne E. McGaugh, Sarah E. Smith, Brian D. Slaughter, Dai Tsuchiya, Jenna L. Persons, Bethany A. Stanhope
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009642 (2021)
PLoS Genetics
PLoS Genetics
Circadian rhythms are nearly ubiquitous throughout nature, suggesting they are critical for survival in diverse environments. Organisms inhabiting largely arrhythmic environments, such as caves, offer a unique opportunity to study the evolution of ci