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Autor:
Agata Poniewierska-Baran, Wojciech Marlicz, Karolina Skonieczna-Żydecka, Mariusz Z. Ratajczak, Rafal Bartoszewski, Sylwia Rzeszotek, Teresa Starzyńska
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0189337 (2018)
PLoS ONE
PLoS ONE
Background Colorectal cancer (CRC) is a leading cause of death in the western world, and its incidence increases with patient age. It is also known that with age there occur changes in the levels of certain hormones, including an increase in the secr
Autor:
Luca Braglia, Andrea Mozzarelli, Sally Maramotti, Stefania Croci, Alessandra Bisagni, F. Zanelli, Maria Pagano, Elena Tagliavini, Massimiliano Paci, Martina Bonacini
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196350 (2018)
PLoS ONE
PLoS ONE
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (gefitinib, erlotinib and afatinib) are indicated as first-line therapy in patients with non-small cell lung cancer (NSCLC) whose tumors harbor activating mutations in the EGFR gene.
Autor:
Jennifer Vogt, Jacqueline M. Tarrant, Priti S. Hegde, Annette T. Byrne, Monika A. Jarzabek, William R Proctor, Rajiv Raja, Jens Brodbeck, John W.M. Martens, Eric P. van der Stok, Cornelis Verhoef, Patrick Dicker, Rupal Desai, Dale Stevens, Gary Cain
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198099 (2018)
PLoS ONE
PLoS One (online), 13(6):e0198099. Public Library of Science
PLoS ONE
PLoS One (online), 13(6):e0198099. Public Library of Science
Drug-related sinusoidal dilatation (SD) is a common form of hepatotoxicity associated with oxaliplatin-based chemotherapy used prior to resection of colorectal liver metastases (CRLM). Recently, hepatic SD has also been associated with anti-delta lik
Autor:
Fadi Brimo, Miguel M. Burnier, Ana Beatriz Toledo Dias, Shraddha Solanki, Madhuri Koti, D. Robert Siemens, Jose Joao Mansure, Alice Yu, Wassim Kassouf
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205746 (2018)
PLoS ONE
PLoS ONE
Tumor-Infiltrating Lymphocytes (TILs) has been shown to be essential to predict disease outcome in several types of cancers. Moreover, the distribution of cytotoxic T lymphocytes (CD8+) and T cells in general (CD3+) have been used to establish an Imm
Autor:
Quentin Loyd, Liza J. Burton, Robin Roberts, Andrew Gacii, Maxine Harlemon, Nathan J. Bowen, Valerie Odero-Marah, Camille Ragin, Veronica Henderson, Ohuod Hawsawi, Simone M. Howard
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203855 (2018)
PLoS ONE
PLoS ONE
African Americans (AA) have higher death rates due to prostate and breast cancer as compared to Caucasian Americans (CA), and few biomarkers have been associated with this disparity. In our study we investigated whether epithelial-mesenchymal transit
Autor:
Ying-Erh Chou, Hui-Ling Chiou, Chih-Tien Chen, Chia-Hsuan Chou, Hsiang-Lin Lee, Shun-Fa Yang, Po-Hui Wang
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198967 (2018)
Background WNT1-inducible signaling pathway protein 1 (WISP1) is a member of CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression is associated with carcinogenesis. In the current study, we focused on examining WISP1 si
Autor:
Christine Rappaport-Fürhauser, Robert Zeillinger, Daniela Muhr, Yen Y. Tan, Jalid Sehouli, Daphne Gschwantler-Kaulich, Marie-Therese Kastner, Sigrid Weingartshofer, Dietmar Pils, Elena Ioana Braicu, Lorenz Semmler, Christian F. Singer
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196142 (2018)
PLoS ONE
PLoS ONE
Screening for ovarian cancer (OC) in women at high risk consists of a combination of carbohydrate antigen 125 (CA125) and transvaginal ultrasound, despite their low sensitivity and specificity. This could be improved by the combination of several bio
Autor:
Julia X. Day, Ming Chen, Jinliang Li, Lizhong Dai, Limin Peng, Shouman Wang, Hui Jiang, Xunxun Xu, Jun Wang, Yueliang Xie, Guoli Li, Xinwu Guo, Lili Tang, Zhi Xiao
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203495 (2018)
Breast cancer, one of the most frequently occurring cancers worldwide, is the leading cause of cancer-related death among women. AKT1, PIK3CA, PTEN and TP53 mutations were common observed in breast cancer representing potential clinical biomarkers fo
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205536 (2018)
PLoS ONE
PLoS ONE
Background Aldehyde dehydrogenase 1A1 (ALDH1A1) encodes an enzyme that oxidizes aldehydes to their corresponding carboxylic acids. In colorectal cancer ALDH1A1 marks cancer stem cells and plays putative roles in tumor progression and drug resistance.
Autor:
Narasimha Reddy Parine, Abdulrahman M Aljebreen, Maha Arafa, Ghadah Alamro, Ftoon Aljarbou, Sooad Al-Daihan, Nourah Almousa, Mohammed M. Alanazi, Abeer Al-Dbass, Shaheerah Alasirri, Arjumand S. Warsy, Abdullah Al-Amri, Othman Alharbi, Mohammad D. Bazzi, Nahla Azzam, Majid A Almadi, Jilani P. Shaik
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197154 (2018)
PLoS ONE
PLoS ONE
Background Colorectal cancer is the leading cause of cancer-related deaths in Saudi Arabia. Cancer has a multifactorial nature and can be described as a disease of altered gene expression. The profiling of gene expression has been used to identify ca