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Autor:
Pedro de Atauri, Josep Tarragó-Celada, Effrosyni Karakitsou, Marta Cascante, Carles Foguet, Míriam Tarrado-Castellarnau, Josep J. Centelles
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 7, p e1009234 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS Computational Biology, Vol 17, Iss 7, p e1009234 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
Metabolic adaptations to complex perturbations, like the response to pharmacological treatments in multifactorial diseases such as cancer, can be described through measurements of part of the fluxes and concentrations at the systemic level and indivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e997e2095349b1209609ba36d766280f
http://hdl.handle.net/2445/180774
http://hdl.handle.net/2445/180774
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001271 (2021)
PLoS Biology
PLoS Biology
Leukotriene B4 (LTB4) is secreted by chemotactic neutrophils, forming a secondary gradient that amplifies the reach of primary chemoattractants. This strategy increases the recruitment range for neutrophils and is important during inflammation. Here,
Autor:
Hyun-Min Kim, Sara E. Beese-Sims, Xiaojuan Zhang, Sisi Tian, Jingjie Chen, Nara Shin, Monica P. Colaiácovo
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009715 (2021)
PLoS Genetics
PLoS Genetics
Histone methylation is dynamically regulated to shape the epigenome and adjust central nuclear processes including transcription, cell cycle control and DNA repair. Lysine-specific histone demethylase 2 (LSD2) has been implicated in multiple types of
Autor:
Penelope A. Morel, Rosemary A. Aogo, Vivienne Crowe, Amber M. Smith, Morgan Craig, Amanda P. Smith, Xiaoyan Deng, Adrianne L. Jenner, Courtney L. Davis, Sofia Alfonso
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009753 (2021)
To understand the diversity of immune responses to SARS-CoV-2 and distinguish features that predispose individuals to severe COVID-19, we developed a mechanistic, within-host mathematical model and virtual patient cohort. Our results suggest that vir
Autor:
Andrei V. Zvyagin, Ewa M. Goldys, Zahra Khabir, Hamidreza Aboulkheyr Es, Jean Paul Thiery, Maxim U. Gavrilov, Ayad G. Anwer, Anna Guller, Vlada S. Rozova, Majid Ebrahimi Warkiani, Anastasiya I. Sokolova
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009193 (2021)
PLoS Computational Biology
PLoS Computational Biology
Epithelial-mesenchymal transition (EMT) and its reverse process, mesenchymal-epithelial transition (MET), are believed to play key roles in facilitating the metastatic cascade. Metastatic lesions often exhibit a similar epithelial-like state to that
Autor:
Zhifu Chen, Yue Yuan, Zhuo Zhao, Haiming Jing, Lang-Huan Lei, Xiaokai Zhang, Hao Zeng, Jinyong Zhang, Qingshan Xiong, Quanming Zou, Xiaoli Zhang, Qiang Gou, Jintao Zou
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009752 (2021)
PLoS Pathogens
PLoS Pathogens
Highly immunogenic exotoxins are used as carrier proteins because they efficiently improve the immunogenicity of polysaccharides. However, their efficiency with protein antigens remains unclear. In the current study, the candidate antigen PA0833 from
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009766 (2021)
PLoS Pathogens
PLoS Pathogens
Neutralizing antibodies to the SARS CoV-2 spike proteins have been issued Emergency Use Authorizations and are a likely mechanism of vaccines to prevent COVID-19. However, benefit of treatment with monoclonal antibodies has only been observed in clin
Autor:
Longhua Guo, Elaine Huang, Ana Alcaraz, Leonid Kruglyak, Sandra Duarte-Vogel, Joshua S. Bloom, Katarina Ho, Zain Kashif, Xinshu Grace Xiao, Steve Sykes, Elise Pham
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009580 (2021)
PLoS Genetics
PLoS genetics, vol 17, iss 6
PLoS Genetics
PLoS genetics, vol 17, iss 6
The squamates (lizards and snakes) are close relatives of birds and mammals, with more than 10,000 described species that display extensive variation in a number of important biological traits, including coloration, venom production, and regeneration
Autor:
Rui D. M. Travasso, Mohammad Reza Salimpour, Ebrahim Shirani, Madjid Soltani, Sahar Jafari Nivlouei, João Carvalho
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009081 (2021)
PLoS Computational Biology
PLoS Computational Biology
The dynamics of tumor growth and associated events cover multiple time and spatial scales, generally including extracellular, cellular and intracellular modifications. The main goal of this study is to model the biological and physical behavior of tu
Autor:
Salvatore Alaimo, Alfredo Pulvirenti, Alessandro La Ferlita, Alfredo Ferro, Philip N. Tsichlis, Bud Mishra, Oksana B. Serebrennikova, Gioacchino P. Marceca, Rosaria Valentina Rapicavoli
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009069 (2021)
PLoS Computational Biology
PLoS Computational Biology
Despite the unprecedented growth in our understanding of cell biology, it still remains challenging to connect it to experimental data obtained with cells and tissues’ physiopathological status under precise circumstances. This knowledge gap often