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Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251408 (2021)
PLoS ONE
PLoS ONE
Aim Nephrolithiasis is a chronic metabolic condition affecting 10% of population worldwide. The present study aimed to investigate the possible protective role of candesartan (CAND) and sodium thiosulfate (STS) in ameliorating ethylene glycol (EG) in
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254167 (2021)
PLoS ONE
PLoS ONE
Dexamethasone provides benefits in patients with coronavirus disease 2019 (COVID-19), although data regarding immunological profiles and viral clearance are limited. This study aimed to evaluate for differences in biomarkers among patients with sever
Autor:
Stuart J. Armstrong, Mike Dennis, Geraint Davies, Faye Lanni, Susan A. Fotheringham, Debbie J Harris, Simon Clark, Ann Williams, Neil K Burton, Oliver Skinner, Nathan R Wiblin
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245922 (2021)
PLoS ONE
PLoS ONE
Optimised pre-clinical models are required for TB drug development to better predict the pharmacokinetics of anti-tuberculosis (anti-TB) drugs to shorten the time taken for novel drugs and combinations to be approved for clinical trial. Microdialysis
Autor:
Fabio Luise, Lucia Sammicheli, Irene Tassinari, Filippo Pieralli, Andrea Ungar, Chiara Beltrame, Riccardo Pini, Rossella Marcucci, Alessandro Milia, Francesca Innocenti, Margherita Giampieri, Alberto Fortini, Fulvio Pomero, Francesca Caldi, Antonio Mancini, Domenico Prisco, Antonio Faraone
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251966 (2021)
PLoS ONE
PLoS ONE
Objective The aim of this study was to assess the incidence of deep vein thrombosis (DVT) of the lower limbs, using serial compression ultrasound (CUS) surveillance, in acutely ill patients with COVID-19 pneumonia admitted to a non-ICU setting. Metho
Autor:
Roger S. Lo, Robert Dimatteo, Ariel M. Azhdam, Yining Liu, Lu Sun, Rong Rong Huang, Willy Hugo, Helena Escuin-Ordinas, Paige Krystofinski, Begoña Comin-Anduix, Antoni Ribas, Tatiana Segura, Philip O. Scumpia, Jordan J. Lee, Alistair J. Cochran
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252597 (2021)
PLoS ONE
PloS one, vol 16, iss 6
PLoS ONE
PloS one, vol 16, iss 6
Wound healing is a multi-step process to rapidly restore the barrier function. This process is often impaired in diabetic patients resulting in chronic wounds and amputation. We previously found that paradoxical activation of the mitogen-activated pr
Autor:
Maria do Socorro de Sousa Cartágenes, José Osvaldo Barbosa Neto, João Batista Santos Garcia, Lyvia Maria Rodrigues de Sousa Gomes, Rayanne Luiza Tajra Mualem Araújo, Nicolau Gregori Czeczko
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245194 (2021)
PLoS ONE
PLoS ONE
Pharmacological treatment of osteoarthritis is still inadequate due to the low efficacy of the drugs used. Dexmedetomidine via the intra-articular (i.a.) route might be an option for the treatment of osteoarthritis-associated pain. The present study
Autor:
Fabio García-García, Gabriela López-Herrera, Héctor Romero-Ramírez, Amayrani Abrego-Peredo, Claudia Sandoval-Montes, Mónica Flores-Muñoz, Enrique Espinosa, Juan Carlos Rodríguez-Alba
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233138 (2020)
PLoS ONE
PLoS ONE
Naringenin is flavonoid mainly found in citrus fruits which has shown several biological properties. In this work, we evaluated the therapeutic potential of the flavonoid Naringenin. Five-month-old B6.MRL-Faslpr/J lupus-prone mice were administered d
Autor:
Zhang Jinfang, Liu Chuiliang, Jiang Qunmeng, He Yuezhen, He Meiyi, Jia Zhenhua, Li Zhipeng, Wang Meirong
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241834 (2020)
PLoS ONE
PLoS ONE
Introduction Ultrasound-guided internal branch of the upper laryngeal nerve block (USG-guided iSLN block) have been used to decrease the perioperative stress response of intubation. It is more likely to be successful than blindly administered superio
Autor:
Shuchun Yu, Huafeng Wei, Maryellen F. Eckenhoff, Qingcheng Meng, Ge Liang, Yun Shi, Yan Wang, Jintao Wang
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229156 (2020)
PLoS ONE
PLoS ONE
Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent. Here, we studied whether the intranasal admin
Autor:
Ana Luiza Sarkis Vieira, Rafael Rocha de Andrade, Selma A S Kuckelhaus, Juliana Gusmão de Araujo, Eduardo Magalhães da Silva, Lucieny Silva Martins Serra, André Luiz Lopes Sampaio
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228943 (2020)
PLoS ONE
PLoS ONE
Introduction Age-related hearing loss (ARHL) is a consequence of aging of the auditory system. The best known mechanism of cell death in ARHL is apoptosis due to increased production of reactive oxygen species. In this context, it is hypothesized tha