Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jan B. Koenderink"'
Autor:
Jan B. Koenderink, Frans G. M. Russel, Ron H.J. Mathijssen, Marcel M. Verbeek, Laurens F. M. Verscheijden, Saskia N. de Wildt, Carlijn H. C. Litjens
Publikováno v:
Plos Computational Biology, 17
Plos Computational Biology, 17, 3
PLoS Computational Biology, 17(3):e1008786. Public Library of Science
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 3, p e1008786 (2021)
Plos Computational Biology, 17, 3
PLoS Computational Biology, 17(3):e1008786. Public Library of Science
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 3, p e1008786 (2021)
Morphine is a widely used opioid analgesic, which shows large differences in clinical response in children, even when aiming for equivalent plasma drug concentrations. Age-dependent brain disposition of morphine could contribute to this variability,
Publikováno v:
Plos Computational Biology, 15, e1007117
PLoS Computational Biology, 15(6):e1007117. Public Library of Science
Plos Computational Biology, 15, 6, pp. e1007117
PLoS Computational Biology
PLoS Computational Biology, Vol 15, Iss 6, p e1007117 (2019)
PLoS Computational Biology, 15(6):e1007117. Public Library of Science
Plos Computational Biology, 15, 6, pp. e1007117
PLoS Computational Biology
PLoS Computational Biology, Vol 15, Iss 6, p e1007117 (2019)
Different pediatric physiologically-based pharmacokinetic (PBPK) models have been described incorporating developmental changes that influence plasma drug concentrations. Drug disposition into cerebrospinal fluid (CSF) is also subject to age-related