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Autor:
Daniel R. Ambruso, Natalie J. Briones, Angelina F. Baroffio, John R. Murphy, Alexander D. Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L. Jones
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Autor:
Clara Dreyling, Martin Hasselmann
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262613 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262613 (2022)
The cellular energy metabolism is one of the most conserved processes, as it is present in all living organisms. Mitochondria are providing the eukaryotic cell with energy and thus their genome and gene expression has been of broad interest for a lon
Autor:
Jamie-Lee M. Thompson, Daniel W. D. West, Thomas M. Doering, Boris P. Budiono, Sarah J. Lessard, Lauren G. Koch, Steven L. Britton, Nuala M. Byrne, Matthew A. Brown, Kevin J. Ashton, Vernon G. Coffey
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0261723 (2022)
PLoS ONE, Vol 17, Iss 1, p e0261723 (2022)
Skeletal muscle atrophy is a physiological response to disuse, aging, and disease. We compared changes in muscle mass and the transcriptome profile after short-term immobilization in a divergent model of high and low responders to endurance training
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0263019 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE, Vol 17, Iss 1, p e0263019 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
Bacterial protein secretion is crucial to the maintenance of viability and pathogenicity. Although many bacterial secretion systems have been identified, the underlying mechanisms regulating their expression are less well explored. Yersinia entomopha
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261250 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261250 (2021)
Many fundamental problems in data mining can be reduced to one or more NP-hard combinatorial optimization problems. Recent advances in novel technologies such as quantum and quantum-inspired hardware promise a substantial speedup for solving these pr
Autor:
Blaine Harlan, Hui Gyu Park, Roman Spektor, Bethany Cummings, J. Thomas Brenna, Paul D. Soloway
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261783 (2021)
PLoS ONE, Vol 16, Iss 12 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261783 (2021)
PLoS ONE, Vol 16, Iss 12 (2021)
Obesity promotes type 2 diabetes and cardiometabolic pathologies. Vertical sleeve gastrectomy (VSG) is used to treat obesity resulting in long-term weight loss and health improvements that precede weight loss; however, the mechanisms underlying the i
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261215 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261215 (2021)
Dehydration Responsive Element Binding (DREB) regulates the expression of numerous stress-responsive genes, and hence plays a pivotal role in abiotic stress responses and tolerance in plants. The study aimed to develop a complete overview of the cis-
Autor:
Harjivan Kohli, Brandon Childs, Travis B. Sullivan, Artem Shevtsov, Eric Burks, Thomas Kalantzakos, Kimberly Rieger-Christ, Alex J. Vanni
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261505 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261505 (2021)
Purpose To better understand the pathophysiology of lichen sclerosus (LS) urethral stricture disease (USD), we aimed to investigate expression profiles of microRNAs (miRNAs) in tissue samples from men undergoing urethroplasty. Methods Urethral strict
Autor:
Qian Lin, Yang Liu, Simin Peng, Chunjie Liu, Tuo Lv, Liping Liao, Yinghui Li, Yanzhou Wang, Zhiyong Fan, Weiguo Wu, Jianguo Zeng, Huajiao Qiu, Xi He, Qiuzhong Dai
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12 (2021)
PLoS ONE, Vol 16, Iss 12, p e0259896 (2021)
PLoS ONE, Vol 16, Iss 12 (2021)
PLoS ONE, Vol 16, Iss 12, p e0259896 (2021)
Magnolol is a bioactive polyphenolic compound commonly found in Magnolia officinalis. The aim of this study is to clarify the contribution of the magnolol additive on the growth performance of Linwu ducklings aging from 7 to 28 d, comparing to the ef