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Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261250 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261250 (2021)
Many fundamental problems in data mining can be reduced to one or more NP-hard combinatorial optimization problems. Recent advances in novel technologies such as quantum and quantum-inspired hardware promise a substantial speedup for solving these pr
Autor:
Harjivan Kohli, Brandon Childs, Travis B. Sullivan, Artem Shevtsov, Eric Burks, Thomas Kalantzakos, Kimberly Rieger-Christ, Alex J. Vanni
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261505 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261505 (2021)
Purpose To better understand the pathophysiology of lichen sclerosus (LS) urethral stricture disease (USD), we aimed to investigate expression profiles of microRNAs (miRNAs) in tissue samples from men undergoing urethroplasty. Methods Urethral strict
Autor:
Banchob Sripa, Piti Ungarreevittaya, Chadamas Sakonsinsiri, Raynoo Thanan, Chawalit Pairojkul, Prakasit Sa Ngiamwibool, Sitthichai Iamsaard, Pirawan Poosekeaw
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259075 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259075 (2021)
Cholangiocarcinoma (CCA) is a group of heterogenous malignancies arising from bile duct epithelium with distinct pathological features. Adaptor proteins have implicated in cell proliferation, migration, and invasion of different cancer cells. The obj
Autor:
Kiyoko Takane, Yoko Hikiba, Chi Zhu, Yoichi Furukawa, Kiyoshi Yamaguchi, Makoto Hirata, Shin Maeda, Tsuneo Ikenoue, Xun Liu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257090 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257090 (2021)
Isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations and their key effector 2-hydroxyglutarate (2-HG) have been reported to promote oncogenesis in various human cancers. To elucidate molecular mechanism(s) associated with IDH1/2 mutations, we establis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252971 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252971 (2021)
A large number of studies have shown that the variation and disorder of miRNAs are important causes of diseases. The recognition of disease-related miRNAs has become an important topic in the field of biological research. However, the identification
Autor:
Mona Aarenstrup Karlsen, Estrid Høgdall, Guy Wayne Novotny, Ib Jarle Christensen, Claus Høgdall, Kira Philipsen Prahm
Publikováno v:
PLoS ONE
Prahm, K P, Høgdall, C K, Karlsen, M A, Christensen, I J, Novotny, G W & Høgdall, E 2021, ' MicroRNA characteristics in epithelial ovarian cancer ', Plos One, vol. 16, no. 6, e0252401, pp. 1-18 . https://doi.org/10.1371/journal.pone.0252401
PLoS ONE, Vol 16, Iss 6, p e0252401 (2021)
Prahm, K P, Høgdall, C K, Karlsen, M A, Christensen, I J, Novotny, G W & Høgdall, E 2021, ' MicroRNA characteristics in epithelial ovarian cancer ', Plos One, vol. 16, no. 6, e0252401, pp. 1-18 . https://doi.org/10.1371/journal.pone.0252401
PLoS ONE, Vol 16, Iss 6, p e0252401 (2021)
The purpose of the current study was to clarify differences in microRNA expression according to clinicopathological characteristics, and to investigate if miRNA profiles could predict cytoreductive outcome in patients with FIGO stage IIIC and IV ovar
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0249375 (2021)
PLoS ONE, Vol 16, Iss 5, p e0249375 (2021)
Background The prognosis of pancreatic cancer (PC) is relatively dismal due to the lack of effective therapy. In this study, we explored the specific functions and molecular mechanisms of miR-107 to uncover effective therapeutic targets for PC. Metho
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251515 (2021)
PLoS ONE, Vol 16, Iss 5, p e0251515 (2021)
Emerging evidence has shown that active enhancers are abundantly transcribed, generating long non-coding RNAs, called enhancer RNAs (eRNAs). While putative eRNAs are often observed from RNA sequencing, the roles of most eRNAs remain largely unknown.
Autor:
Tomohiro Nakayama, Yoko Suwabe, Naoya Yachiku, Mana Sugimura, Shinichi Namba, Manami Kuji, Hiroshi Sugiya, Taku Kitanaka, Tadayoshi Konno, Rei Nakano, Nanako Kitanaka
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0243859 (2021)
PLoS ONE, Vol 16, Iss 2, p e0243859 (2021)
The rate of glucose uptake dramatically increases in cancer cells even in the presence of oxygen and fully functioning mitochondria. Cancer cells produce ATP by glycolysis rather than oxidative phosphorylation under aerobic conditions, a process term
Autor:
Marat S. Pavlyukov, L. I. Patrushev, Mikhail I. Shakhparonov, Alina M. Gamisoniya, Ksenia Anufrieva, Ksenia V. Morozova, T. F. Kovalenko, Lyudmila A. Ozolinya, Mikhail Yu. Bobrov, Yulia E. Dobrokhotova
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 1, p e0243093 (2021)
PLoS ONE, Vol 16, Iss 1, p e0243093 (2021)
The processed pseudogene PTENP1 is involved in the regulation of the expression of the PTEN and acts as a tumor suppressor in many types of malignances. In our previous study we showed that PTENP1 methylation is present not only in tumor, but also in