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Autor:
Daniel R. Ambruso, Natalie J. Briones, Angelina F. Baroffio, John R. Murphy, Alexander D. Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L. Jones
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Autor:
Blaine Harlan, Hui Gyu Park, Roman Spektor, Bethany Cummings, J. Thomas Brenna, Paul D. Soloway
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261783 (2021)
PLoS ONE, Vol 16, Iss 12 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261783 (2021)
PLoS ONE, Vol 16, Iss 12 (2021)
Obesity promotes type 2 diabetes and cardiometabolic pathologies. Vertical sleeve gastrectomy (VSG) is used to treat obesity resulting in long-term weight loss and health improvements that precede weight loss; however, the mechanisms underlying the i
Autor:
Harjivan Kohli, Brandon Childs, Travis B. Sullivan, Artem Shevtsov, Eric Burks, Thomas Kalantzakos, Kimberly Rieger-Christ, Alex J. Vanni
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261505 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261505 (2021)
Purpose To better understand the pathophysiology of lichen sclerosus (LS) urethral stricture disease (USD), we aimed to investigate expression profiles of microRNAs (miRNAs) in tissue samples from men undergoing urethroplasty. Methods Urethral strict
Autor:
Tze Chiew Christie Soo, Subha Bhassu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258655 (2021)
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258655 (2021)
Diseases have remained the major issue for shrimp aquaculture industry for decades by which different shrimp species demonstrated alternative disease resistance or tolerance. However, there had been insufficient studies on the underlying host mechani
Autor:
Gina R. Rayat, Yulian Wu, Wenlong Huang, Kaja Matovinovic, Kunsong Chen, Xian Li, Mazzen Black, Jack H. Jhamandas, Nancy Gupta, Wen Fu, Jennifer Croden, Josue Rodrigues Silva
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258208 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258208 (2021)
Islet transplantation is being considered as an alternative treatment for type 1 diabetes. Despite recent progress, transplant recipients continue to experience progressive loss of insulin independence. Cyanidin-3-O-Glucoside (C3G) has shown to be pr
Autor:
Meseret Abebe, Rawleigh Howe, Helina Mollalign, Katrin Bauer, Vincent C. Marconi, Wegene Tamene, Liya Wassie, Amha Kebede, Ulrich Sack
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258122 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258122 (2021)
Introduction PDL1 and its interaction with PD1 is implicated in immune dysfunction in TB and HIV. The expression of PDL1 on multiple subsets of monocytes as well as their associations with cytokines and microbial products have not been well studied.
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
Gluten-specific CD4+ T cells drive the pathogenesis of celiac disease and circulating gluten-specific T cells can be identified by staining with HLA-DQ:gluten tetramers. In this first single-cell RNA-seq study of tetramer-sorted T cells from untreate
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257908 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257908 (2021)
In response to various stimuli, naïve macrophages usually polarize to M1 (classically activated) or M2 (alternatively activated) cells with distinct biological functions. Neuronal nitric oxide synthase (NOS1) is involved in M1 macrophage polarizatio
Autor:
Takumi Kayukawa, Mikio Yoshiyama, Kiyoshi Kimura, Gaku Akiduki, Kazuyo Watanabe, Kakeru Yokoi, Masatsugu Hatakeyama, Hiroko Hoshida
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257770 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257770 (2021)
Cultured cells are a very powerful tool for investigating biological events in vitro; therefore, cell lines have been established not only in model insect species, but also in non-model species. However, there are few reports on the establishment of
Autor:
Xueying Shi, Qianyi Chen, Zeng Fen, Nan Yang, Shifeng Fang, Shilin Xia, Yuankuan Jiang, Yingming Chu, Jingrong Lin, Jingyuan Zheng
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0255293 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
PLoS ONE, Vol 16, Iss 8, p e0255293 (2021)
PLoS ONE, Vol 16, Iss 8 (2021)
Uveal melanoma (UVM), the most common primary intraocular malignancy, has a high mortality because of a high propensity to metastasize. Our study analyzed prognostic value and immune-related characteristics of CARD11 in UVM, hoping to provide a poten