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Autor:
Thomas F. McElrath, Aishwarya P. Yadama, Scott T. Weiss, Hooman Mirzakhani, Augusto A. Litonjua
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0227193 (2020)
PLoS ONE, Vol 15, Iss 1, p e0227193 (2020)
BackgroundWe conducted a literature review on the studies that investigated the relationship of preterm birth, including spontaneous preterm birth (sPTB), with vitamin D status. Overall, these studies demonstrated that the incidence of sPTB was assoc
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0227603 (2020)
PLoS ONE, Vol 15, Iss 1, p e0227603 (2020)
In-vitro studies with different Fanconi anemia (FA) cell lines and FANC gene silenced cell lines indicating involvement of mitochondria function in pathogenesis of FA have been reported. However, in-vivo studies have not been studied so far to unders
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0227596 (2020)
PLoS ONE, Vol 15, Iss 1, p e0227596 (2020)
High tibial osteotomy (HTO) is a well-established treatment for medial compartmental knee osteoarthritis. Several microRNAs (miRNAs) are involved in osteoarthritis progression and are useful as osteoarthritis-related biomarkers. In this prospective s
Autor:
Víctor Meza-Carmen, Martha I. Ramírez-Díaz, Soo Chan Lee, Irvin E. Jácome-Galarza, Carlos Pérez-Arques, Nancy Y. Reyes-Mares, Rafael Ortiz-Alvarado, J. Alberto Patiño-Medina, Marco I. Valle-Maldonado, Victoriano Garre, Jesús Campos-García, Verónica Anaya-Martínez, Rosa Elvira Nuñez-Anita
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0226682 (2019)
PLoS ONE, Vol 14, Iss 12, p e0226682 (2019)
Mucor circinelloides is one of the causal agents of mucormycosis, an emerging and high mortality rate fungal infection produced by asexual spores (sporangiospores) of fungi that belong to the order Mucorales. M. circinelloides has served as a model g
Autor:
Marti Jett, Allison Hoke, Jesse Lynch, Aarti Gautam, Rasha Hammamieh, Michael Levangie, Leanne Detwiler, Stacy-Ann Miller, Seshamalini Srinivasan, Bintu Sowe, Duncan E. Donohue
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0225137 (2019)
PLoS ONE, Vol 14, Iss 12, p e0225137 (2019)
Gene expression profiling using blood samples is a valuable tool for biomarker discovery in clinical studies. Different whole blood RNA collection and processing methods are highly variable and might confound comparisons of results across studies. Th
Autor:
Flávia de Oliveira Cardoso, Carla Junqueira Moragas Tellis, Iara dos Santos da Silva Oliveira, Maria Dutra Behrens, Fernando Almeida-Souza, Aracélio Viana Colares, Maria do Socorro dos Santos Chagas, Ana Lucia Abreu-Silva, Kátia da Silva Calabrese
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0225275 (2019)
PLoS ONE, Vol 14, Iss 12, p e0225275 (2019)
Species of the Vernonia genius are widely distributed across the world. In traditional communities, they are commonly used in popular medicine for the treatment of inflammatory diseases. The objective of the present study was to evaluate the anti-inf
Autor:
Min Hyeong Lee, So-Young Jung, Keum-Jin Yang, Joohyung Lee, Dohee Lee, Yoonho Kim, Dong-Kee Kim
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0226769 (2019)
PLoS ONE, Vol 14, Iss 12, p e0226769 (2019)
The production of reactive oxygen species (ROS) by cisplatin is one of the major mechanisms of cisplatin-induced cytotoxicity. We examined the preventive effect of α-lipoic acid (LA) on cisplatin-induced toxicity via its antioxidant effects on in vi
Autor:
Richard Kuo, Mark P. Stevens, Richard A. Bailey, Dominika Borowska, Lonneke Vervelde, Peter K. Kaiser, Kellie A. Watson
Publikováno v:
PLoS ONE
PLOS ONE
PLoS ONE, Vol 14, Iss 12, p e0225658 (2019)
Borowska, D, Kuo, R, Bailey, R A, Watson, K, Kaiser, P, Vervelde, L & Stevens, M 2019, ' Highly multiplexed quantitative PCR-based platform for evaluation of chicken immune responses ', PLoS ONE . https://doi.org/10.1371/journal.pone.0225658
PLOS ONE
PLoS ONE, Vol 14, Iss 12, p e0225658 (2019)
Borowska, D, Kuo, R, Bailey, R A, Watson, K, Kaiser, P, Vervelde, L & Stevens, M 2019, ' Highly multiplexed quantitative PCR-based platform for evaluation of chicken immune responses ', PLoS ONE . https://doi.org/10.1371/journal.pone.0225658
To address the need for sensitive high-throughput assays to analyse avian innate and adaptive immune responses, we developed and validated a highly multiplexed qPCR 96.96 Fluidigm Dynamic Array to analyse the transcription of chicken immune-related g
Autor:
Helena Dankova, Eva Sticova, Ondrej Seda, Pavel Trunecka, Denisa Erhartová, Monika Cahova, Marie Heczkova, Irena Míková, Julius Spicak
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 11, p e0224820 (2019)
PLoS ONE, Vol 14, Iss 11, p e0224820 (2019)
Background & aims MiR-33a has emerged as a critical regulator of lipid homeostasis in the liver. Genetic deficiency of miR-33a aggravates liver steatosis in a preclinical model of non-alcoholic fatty liver disease (NAFLD), and relative expression of
Autor:
Christoforos Nikolaou, Eralda Salataj, Charalampos G. Spilianakis, Chrysoula Stathopoulou, Róbert A. Hafþórsson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 11, p e0223759 (2019)
PLoS ONE, Vol 14, Iss 11, p e0223759 (2019)
microRNAs are of vital importance for the regulation of the adaptive and innate immune responses, modulating gene expression at the post transcriptional level. Although there is cumulative information regarding the steady state mature microRNA levels