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Autor:
Daniel R. Ambruso, Natalie J. Briones, Angelina F. Baroffio, John R. Murphy, Alexander D. Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L. Jones
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced
Autor:
Banchob Sripa, Piti Ungarreevittaya, Chadamas Sakonsinsiri, Raynoo Thanan, Chawalit Pairojkul, Prakasit Sa Ngiamwibool, Sitthichai Iamsaard, Pirawan Poosekeaw
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259075 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0259075 (2021)
Cholangiocarcinoma (CCA) is a group of heterogenous malignancies arising from bile duct epithelium with distinct pathological features. Adaptor proteins have implicated in cell proliferation, migration, and invasion of different cancer cells. The obj
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0258903 (2021)
PLoS ONE, Vol 16, Iss 11, p e0258903 (2021)
Most transcription in Trypanosoma brucei is constitutive and polycistronic. Consequently, the parasite relies on post-transcriptional mechanisms, especially affecting translation initiation and mRNA decay, to control gene expression both at steady-st
Autor:
Roman A. Perez, Elia Bosch-Rué, Raquel Rodríguez-González, Leire Díez-Tercero, Begoña María Bosch-Canals
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE, Vol 16, Iss 10, p e0259125 (2021)
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE, Vol 16, Iss 10, p e0259125 (2021)
The use of copper (Cu2+) and cobalt (Co2+) has been described to stimulate blood vessel formation, a key process for the success of tissue regeneration. However, understanding how different concentrations of these ions affect cellular response is imp
Autor:
Meseret Abebe, Rawleigh Howe, Helina Mollalign, Katrin Bauer, Vincent C. Marconi, Wegene Tamene, Liya Wassie, Amha Kebede, Ulrich Sack
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258122 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258122 (2021)
Introduction PDL1 and its interaction with PD1 is implicated in immune dysfunction in TB and HIV. The expression of PDL1 on multiple subsets of monocytes as well as their associations with cytokines and microbial products have not been well studied.
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
Gluten-specific CD4+ T cells drive the pathogenesis of celiac disease and circulating gluten-specific T cells can be identified by staining with HLA-DQ:gluten tetramers. In this first single-cell RNA-seq study of tetramer-sorted T cells from untreate
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0249438 (2021)
PLoS ONE, Vol 16, Iss 9, p e0249438 (2021)
Muscle derived stem cells (MDSCs) and myoblast play an important role in myotube regeneration when muscle tissue is injured. However, these cells can be induced to differentiate into adipocytes once exposed to PPARγ activator like EPA and DHA that a
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257908 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257908 (2021)
In response to various stimuli, naïve macrophages usually polarize to M1 (classically activated) or M2 (alternatively activated) cells with distinct biological functions. Neuronal nitric oxide synthase (NOS1) is involved in M1 macrophage polarizatio
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0256996 (2021)
PLoS ONE, Vol 16, Iss 9, p e0256996 (2021)
Dyslipidemia, atherosclerosis, and cardiovascular events can be prevented, or treated, using statins, alone or in combination with ezetimibe. The aim of the study was to compare the direct pleiotropic effects of two commonly-used statins (atorvastati