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Autor:
Peter E. M. Butler, Michelle Griffin, Esther Hansen, David Abraham, Ravi Kumar, Debbie F. Hunt, Christopher P. Denton, Caroline M. Ryan, Aurora Almadori
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0218068 (2019)
PLoS ONE, Vol 14, Iss 7, p e0218068 (2019)
Oro-facial fibrosis in systemic sclerosis (Scleroderma;SSc) has a major impact on mouth function, facial appearance, and patient quality of life. Lipotransfer is a method of reconstruction that can be used in the treatment of oro-facial fibrosis. The
Autor:
Taku Kitanaka, Nanako Kitanaka, Rei Nakano, Tomohiro Nakayama, Hiroshi Sugiya, Shinichi Namba, Kanae Sugiura, Tadayoshi Konno
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0220262 (2019)
PLoS ONE, Vol 14, Iss 7, p e0220262 (2019)
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of the immune response and inflammation. In this study, we investigated effect of the proinflammatory cytokine interleukin-1β (IL-1β) on IL-6 expression in canine dermal fibr
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0217580 (2019)
PLoS ONE, Vol 14, Iss 6, p e0217580 (2019)
Cebpa encodes a transcription factor (TF) that plays an instructive role in the development of multiple myeloid lineages. The expression of Cebpa itself is finely modulated, as Cebpa is expressed at high and intermediate levels in neutrophils and mac
Autor:
Marta Jezova, Katerina Adamkova, Renata Veselská, Petr Chlapek, Viera Dobrotkova, Jaroslav Sterba, Pavel Mazánek
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218269 (2019)
PLoS ONE, Vol 14, Iss 6, p e0218269 (2019)
Although the administration of retinoids represents an important part of treatment for children suffering from high-risk neuroblastomas, approximately 50% of these patients do not respond to this therapy or develop resistance to retinoids during trea
Autor:
Jeffrey Koury, Ana Ramirez, Chen Xie, Tom Ramos, Charli Dong, Chad Maki, Fari Izadyar, David Clark, Jerry Harb, Yvonne Drechsler, Jijun Hao, Gagandeep Kaur
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218670 (2019)
PLoS ONE, Vol 14, Iss 6, p e0218670 (2019)
Canine Atopic Dermatitis (AD) is a common complex and multifactorial disease involving immune dysregulation, genetic predisposition, skin barrier defects, environmental factors and allergic sensitization. To date, diagnosis of canine AD relies on a c
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0217680 (2019)
PLoS ONE, Vol 14, Iss 6, p e0217680 (2019)
The transcription elongation factor TFIIS is encoded by a three member gene family in vertebrates. Here we show that one member of this family, TCEA3, is upregulated during skeletal muscle differentiation and acts to promote gene activation by the my
Autor:
Bassam Badran, Eva Hamade, May F. Mrad, Charbel A. Mouawad, Aida Habib, Ayad A. Jaffa, Ghewa A. El-Achkar, Roberto Motterlini
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2019, 14 (5), pp.e0216405. ⟨10.1371/journal.pone.0216405⟩
PLoS ONE, Vol 14, Iss 5, p e0216405 (2019)
PLoS ONE, 2019, 14 (5), pp.e0216405. ⟨10.1371/journal.pone.0216405⟩
PLoS ONE, Public Library of Science, 2019, 14 (5), pp.e0216405. ⟨10.1371/journal.pone.0216405⟩
PLoS ONE, Vol 14, Iss 5, p e0216405 (2019)
PLoS ONE, 2019, 14 (5), pp.e0216405. ⟨10.1371/journal.pone.0216405⟩
International audience; Statins exert pleiotropic and beneficial anti-inflammatory and antioxidant effects. We have previously reported that macrophages treated with statins increased the expression of heme oxygenase-1 (HO-1), an inducible anti-infla
Autor:
Kristina N. Whisenhunt, Eranga N. Vithana, Neerja Karnani, Cheryl Ngo, Terri L. Young, Wei Jie Seow, Hong Pan, Stuart W. Tompson, Veluchamy A Barathi, Pirro G. Hysi, Seang-Mei Saw, Yap Seng Chong, Suh-Hang H. Juo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0214791 (2019)
PLoS ONE, Vol 14, Iss 5, p e0214791 (2019)
ObjectivesTo assess whether epigenetic mechanisms affecting gene expression may be involved in the pathogenesis of early-onset myopia, we performed genome-wide DNA methylation analyses of umbilical cord tissues, and assessed any associations between
Autor:
Ruth Davenport, W. Brad Barbazuk, Aaron Gabriel W. Sandoval, J. Lucas Boatwright, Jason O. Brant, Malcolm Maden
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0216228 (2019)
PLoS ONE, Vol 14, Iss 5, p e0216228 (2019)
The African spiny mouse, Acomys spp., is capable of scar-free dermal wound healing. Here, we have performed a comprehensive analysis of gene expression throughout wound healing following full-thickness excisional dermal wounds in both Acomys cahirinu
Autor:
Gerard W. Dougherty, Victor L. Jensen, Jan Frederik Scheel, Katarzyna Szymanska, Uwe Wolfrum, Radek Szklarczyk, Miriam Schmidts, Julie Kennedy, Erwin van Wijk, Brunella Franco, Toby J. Gibson, Machteld M. Oud, Chunmei Li, Nils J. Lambacher, Erik de Vrieze, Grischa Toedt, Teunis J. P. van Dam, Karsten Boldt, Heymut Omran, Yves Texier, Rachel H. Giles, Ronald Roepman, Kirsten A. Wunderlich, Sylvia E. C. van Beersum, Oliver E. Blacque, Thanh-Minh T. Nguyen, Konstantinos Koutroumpas, Hannie Kremer, Nicola Horn, Martijn A. Huynen, Michel R. Leroux, Gabrielle Wheway, Rim Hjeij, Philip L. Beales, Gisela G. Slaats, Robert B. Russell, Robin van der Lee, François Képès, Yasmin Wissinger, Barbara Knapp, Dorus A. Mans, Suzanne Rix, Marius Ueffing, Colin A. Johnson, Stef J.F. Letteboer, Victor Hernandez-Hernandez, Qianhao Lu, Jeroen van Reeuwijk
Publikováno v:
PLoS ONE
PLoS One, 14
PLoS One. Public Library of Science
PloS one
PLOS ONE
PLOS ONE, 14(5):0216705. Public Library of Science
PLoS ONE, Vol 14, Iss 5, p e0216705 (2019)
PLoS One, 14, 5
PLoS One, 14
PLoS One. Public Library of Science
PloS one
PLOS ONE
PLOS ONE, 14(5):0216705. Public Library of Science
PLoS ONE, Vol 14, Iss 5, p e0216705 (2019)
PLoS One, 14, 5
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wide range of genetic diseases collectively called ciliopathies. The current rate at which new ciliopathy genes are identified suggests that many ciliar