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Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0249438 (2021)
PLoS ONE, Vol 16, Iss 9, p e0249438 (2021)
Muscle derived stem cells (MDSCs) and myoblast play an important role in myotube regeneration when muscle tissue is injured. However, these cells can be induced to differentiate into adipocytes once exposed to PPARγ activator like EPA and DHA that a
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257908 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257908 (2021)
In response to various stimuli, naïve macrophages usually polarize to M1 (classically activated) or M2 (alternatively activated) cells with distinct biological functions. Neuronal nitric oxide synthase (NOS1) is involved in M1 macrophage polarizatio
Autor:
Christel Rousseaux, Paolo Spagnolo, Silvia Speca, Caroline Dubuquoy, Pierre Desreumaux, Philippe Chavatte
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257281 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257281 (2021)
The development of more effective, better tolerated drug treatments for progressive pulmonary fibrosis (of which idiopathic pulmonary fibrosis is the most common and severe form) is a research priority. The peroxisome proliferator-activated receptor
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0256299 (2021)
PLoS ONE, Vol 16, Iss 8, p e0256299 (2021)
Tamoxifen is an estrogen receptor (ER) ligand with widespread use in clinical and basic research settings. Beyond its application in treating ER-positive cancer, tamoxifen has been co-opted into a powerful approach for temporal-specific genetic alter
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254674 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254674 (2021)
Trophoblast giant cells (TGCs), a mouse trophoblast subtype, have large amounts of cytoplasm and high ploidy levels via endocycles. The diverse functions and gene expression profiles of TGCs have been studied well, but their nuclear structures remain
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254731 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254731 (2021)
Epidermis is the most outer layer of the skin and a physical barrier protecting the internal tissues from mechanical and environmental insults. The basal keratinocytes, which, through proliferation and differentiation, supply diverse cell types for e
Autor:
Xiangfan Zhang, Alexandre Boyer, Guillaume St-Jean, Adrien Levasseur, Makoto C. Nagano, Nour Abou Nader, Derek Boerboom
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251911 (2021)
PLoS ONE, Vol 16, Iss 5, p e0251911 (2021)
Spermatogenesis requires that a careful balance be maintained between the self-renewal of spermatogonial stem cells (SSCs) and their commitment to the developmental pathway through which they will differentiate into spermatozoa. Recently, a series of
Autor:
Fumio Takei, Itziar Martinez-Gonzalez, Catherine A. Steer, Laura Mathä, Hanjoo Shim, Yi Han Yin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 3, p e0214286 (2019)
PLoS ONE, Vol 16, Iss 5, p e0252257 (2021)
PLoS ONE, Vol 14, Iss 3, p e0214286 (2019)
PLoS ONE, Vol 16, Iss 5, p e0252257 (2021)
Epidemiological studies have shown sex differences in prevalence of non-allergic asthma. Recent reports demonstrated negative effects of androgen signaling on group 2 innate lymphoid cells (ILC2s), explaining a potential mechanism behind sex bias in
Autor:
Diva Denelle Spadacci-Morena, Anuska Marcelino Alvares Saraiva, Fabiana Toshie de Camargo Konno, Elizabeth Cristina Perez, Luciane Costa Dalboni, Jéssica Feliciana Codeceira, Maria Anete Lallo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0247658 (2021)
PLoS ONE, Vol 16, Iss 3, p e0247658 (2021)
Microsporidia are recognized as opportunistic pathogens in individuals with immunodeficiencies, especially related to T cells. Although the activity of CD8+ T lymphocytes is essential to eliminate these pathogens, earlier studies have shown significa
Autor:
Sari Honda, Akiko Kojima-Yuasa, Kasumi Fujita, Shigenori Kumazawa, Takumi Sonoda, Isao Matsui-Yuasa, Toshio Norikura
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0248073 (2021)
PLoS ONE, Vol 16, Iss 3, p e0248073 (2021)
研究グループは、ココアパウダーやコーヒーパウダーの代替品としても用いられるカロブパウダー抽出物が抗肥満効果を有することを、細胞レベルおよび動物レベルで解明しました。