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Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257908 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257908 (2021)
In response to various stimuli, naïve macrophages usually polarize to M1 (classically activated) or M2 (alternatively activated) cells with distinct biological functions. Neuronal nitric oxide synthase (NOS1) is involved in M1 macrophage polarizatio
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254674 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254674 (2021)
Trophoblast giant cells (TGCs), a mouse trophoblast subtype, have large amounts of cytoplasm and high ploidy levels via endocycles. The diverse functions and gene expression profiles of TGCs have been studied well, but their nuclear structures remain
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254731 (2021)
PLoS ONE, Vol 16, Iss 7, p e0254731 (2021)
Epidermis is the most outer layer of the skin and a physical barrier protecting the internal tissues from mechanical and environmental insults. The basal keratinocytes, which, through proliferation and differentiation, supply diverse cell types for e
Autor:
Xiangfan Zhang, Alexandre Boyer, Guillaume St-Jean, Adrien Levasseur, Makoto C. Nagano, Nour Abou Nader, Derek Boerboom
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251911 (2021)
PLoS ONE, Vol 16, Iss 5, p e0251911 (2021)
Spermatogenesis requires that a careful balance be maintained between the self-renewal of spermatogonial stem cells (SSCs) and their commitment to the developmental pathway through which they will differentiate into spermatozoa. Recently, a series of
Autor:
Stacey B. Andersen, Erica Lin, Matt Trau, Lars K. Nielsen, Panagiotis Chrysanthopoulos, Jessica L. Schwaber, Darren Korbie
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246107 (2021)
PLoS ONE, Vol 16, Iss 2, p e0246107 (2021)
With the exception of a few master transcription factors, regulators of neutrophil maturation are poorly annotated in the intermediate phenotypes between the granulocyte-macrophage progenitor (GMP) and the mature neutrophil phenotype. Additional chal
Autor:
Daniel Ferguson, Niladri S. Kar, Joseph A. DiDonato, James T. Ryaby, Nianli Zhang, Erik I. Waldorff
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0247659 (2021)
PLoS ONE, Vol 16, Iss 2, p e0247659 (2021)
Pulsed-electromagnetic-field (PEMF) treatment was found to enhance cellular differentiation of the mouse preosteoblast, MC3T3-E1, to a more osteoblastic phenotype. Differentiation genes such as Alp, BSPI, cFos, Ibsp, Osteocalcin, Pthr1 and Runx2 show
Autor:
Marzia Ognibene, Annalisa Pezzolo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0244069 (2020)
PLoS ONE, Vol 15, Iss 12, p e0244069 (2020)
In a previous study, we demonstrated that CHL1, the neuronal cell adhesion molecule close homolog of L1, acts as a tumor suppressor in human neuroblastoma (NB), a still highly lethal childhood malignancy, influencing its differentiation and prolifera
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0241685 (2020)
PLoS ONE, Vol 15, Iss 11, p e0241685 (2020)
The efficiency of cell reprogramming in two-dimensional (2D) cultures is limited. Given that cellular stemness is intimately related to microenvironmental changes, 3D cell cultures have the potential of overcoming this limited capacity by allowing ce
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0241367 (2020)
PLoS ONE, Vol 15, Iss 11, p e0241367 (2020)
Epigenetics plays a fundamental role in cellular development and differentiation; epigenetic mechanisms, such as DNA methylation, are involved in gene regulation and the exquisite nuance of expression changes seen in the journey from pluripotency to
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e88757 (2014)
PLoS ONE, Vol 15, Iss 10, p e0240732 (2020)
PLoS ONE, Vol 9, Iss 2, p e88757 (2014)
PLoS ONE, Vol 15, Iss 10, p e0240732 (2020)
Hmga2 protein belongs to the non-histone chromosomal high-mobility group (HMG) protein family. HMG proteins have been shown to function as architectural transcription regulators, facilitating enhanceosome formation on a variety of mammalian promoters