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Autor:
Daniel R. Ambruso, Natalie J. Briones, Angelina F. Baroffio, John R. Murphy, Alexander D. Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L. Jones
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Autor:
Masanori A. Murayama, Erika Takada, Kenji Takai, Nagisa Arimitsu, Jun Shimizu, Tomoko Suzuki, Noboru Suzuki
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0260838 (2022)
PLoS ONE, Vol 17, Iss 1, p e0260838 (2022)
The immune checkpoint molecules such as PD-L1 and PD-L2 have a substantial contribution to cancer immunotherapy including breast cancer. Microarray expression profiling identified several molecular subtypes, namely luminal-type (with a good-prognosis
Autor:
Christy L. Rhine, Christopher Neil, Jing Wang, Samantha Maguire, Luke Buerer, Mitchell Salomon, Ijeoma C. Meremikwu, Juliana Kim, Natasha T. Strande, William G. Fairbrother
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 18, Iss 1 (2022)
PLoS Genetics, Vol 18, Iss 1, p e1009884 (2022)
PLoS Genetics, Vol 18, Iss 1 (2022)
PLoS Genetics, Vol 18, Iss 1, p e1009884 (2022)
To determine the contribution of defective splicing in Autism Spectrum Disorders (ASD), the most common neurodevelopmental disorder, a high throughput Massively Parallel Splicing Assay (MaPSY) was employed and identified 42 exonic splicing mutants ou
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262074 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262074 (2022)
Introduction Previous studies have demonstrated that cytokines, transforming growth factor (TGF-β1), and brain-derived neurotrophic factor (BDNF) can impact the intensity of pain in rodents. However, the roles of cytokines, TGF-β1 and BDNF in human
Autor:
Christopher J. Fields, Lu Li, Nicholas M. Hiers, Tianqi Li, Peike Sheng, Taha Huda, Jixiu Shan, Lauren Gay, Tongjun Gu, Jiang Bian, Michael S. Kilberg, Rolf Renne, Mingyi Xie
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 12, p e1009934 (2021)
PLoS Genetics, Vol 17, Iss 12, p e1009934 (2021)
MicroRNAs (miRNA) are short non-coding RNAs widely implicated in gene regulation. Most metazoan miRNAs utilize the RNase III enzymes Drosha and Dicer for biogenesis. One notable exception is the RNA polymerase II transcription start sites (TSS) miRNA
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261730 (2021)
In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 12, p e1009711 (2021)
PLoS Genetics, Vol 17, Iss 12, p e1009711 (2021)
Polycystic kidney disease is an inherited degenerative disease in which the uriniferous tubules are replaced by expanding fluid-filled cysts that ultimately destroy organ function. Autosomal dominant polycystic kidney disease (ADPKD) is the most comm
Autor:
Martin V. Hamann, Niklas Beschorner, Xuan-Khang Vu, Ilona Hauber, Ulrike C. Lange, Bjoern Traenkle, Philipp D. Kaiser, Daniel Foth, Carola Schneider, Hildegard Büning, Ulrich Rothbauer, Joachim Hauber
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 12, p e0261269 (2021)
PLoS ONE, Vol 16, Iss 12, p e0261269 (2021)
Adeno-associated viruses (AAV) are considered non-pathogenic in humans, and thus have been developed into powerful vector platforms for in vivo gene therapy. Although the various AAV serotypes display broad tropism, frequently infecting multiple tiss
Autor:
Kristin V. Carson-Chahhoud, Brian J. Smith, Matthew J. Peters, Malcolm P. Brinn, Faisal Ameer, Kuljit Singh, Robert Fitridge, John Litt, David Edwards, Simon A. Koblar, Jim Jannes, Antony J. Veale, Sharon Goldsworthy, Khin Hnin, Adrian J. Esterman
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231095 (2020)
PLoS ONE, Vol 15, Iss 4, p e0231095 (2020)
IntroductionVarenicline tartrate is superior for smoking cessation to other tobacco cessation therapies by 52 weeks, in the outpatient setting. We aimed to evaluate the long-term (104 week) efficacy following a standard course of inpatient-initiated
Autor:
Sho Yokoyama, Takashi Kojima, Rie Horai, Hideki Nakamura, Hiroyuki Sato, Yoshiki Tanaka, Yukihito Kato, Mari Mitamura, Kazuo Ichikawa, Kiyoshi Tanaka
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0260525 (2021)
PLoS ONE, Vol 16, Iss 11, p e0260525 (2021)
Purpose To evaluate the age-related change in color visual acuity (CVA) in normal eyes. Methods In total, 162 normal eyes (162 subjects, women: 52, men: 110, age range: 15–68 years) with best-corrected visual acuity (BCVA) ≥20/13 were enrolled. F