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Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009490 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009490 (2021)
Treatment and control of schistosomiasis depends on a single drug, praziquantel, but this is not ideal for several reasons including lack of potency against the juvenile stage of the parasite, dose size, and risk of resistance. We have optimised the
Publikováno v:
PLoS Biology
PLoS Biology, Vol 14, Iss 1, p e1002336 (2016)
PLoS Biology, Vol 14, Iss 1, p e1002336 (2016)
Leukotriene B4 (LTB4) is secreted by chemotactic neutrophils, forming a secondary gradient that amplifies the reach of primary chemoattractants. This strategy increases the recruitment range for neutrophils and is important during inflammation. Here,
Autor:
Rafael Rodrigues Lima, Marília Afonso Rabelo Buzalaf, Bruna Puty, Leonardo Oliveira Bittencourt, Iago César da Costa Nogueira, Edivaldo Herculano Corrêa de Oliveira
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0251200 (2021)
Repositório Digital do Instituto Evandro Chagas (Patuá)
Instituto Evandro Chagas (IEC)
instacron:IEC
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE, Vol 16, Iss 6, p e0251200 (2021)
Repositório Digital do Instituto Evandro Chagas (Patuá)
Instituto Evandro Chagas (IEC)
instacron:IEC
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
This study was supported by the Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico ? Brasil (CNPq) (grant no. 435093/ 2018-5) and the Coordination of Personal Improvement of Higher Education ? (CAPES) Brasil (Finance Code 001). Federal Uni
Autor:
Shuqin Li, Meiting Wang, Yingdong Song, Wei Zhang, Fanghong Shao, Xiaolin Liang, Ge Shan, Xiangting Wang, Junxia Lu, Bowen Zhang, Meng Gong, Wei Wang, Yan Jin, Zhi Zhang
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 6, p e3001297 (2021)
PLoS Biology, Vol 19, Iss 6, p e3001297 (2021)
Recent studies have shown that long noncoding RNAs (lncRNAs) are critical regulators in the central nervous system (CNS). However, their roles in the cerebellum are currently unclear. In this work, we identified the isoform 204 of lncRNA Gm2694 (desi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252895 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252895 (2021)
Illicit drugs are known to affect central nervous system (CNS). Majorly psychostimulants such as cocaine, methamphetamine (METH) and opioids such as morphine are known to induce epigenetic changes of histone modifications and chromatin remodeling whi
Autor:
Gough G. Au, Angela R. Harrison, Glenn A. Marsh, Gregory W. Moseley, Stephen M. Rawlinson, Cassandra T. David, Megan Dearnley, Diane Green, Shawn Todd
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
PLoS Pathogens, Vol 17, Iss 6, p e1009636 (2021)
Many viruses target signal transducers and activators of transcription (STAT) 1 and 2 to antagonise antiviral interferon signalling, but targeting of signalling by other STATs/cytokines, including STAT3/interleukin 6 that regulate processes important
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252587 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252587 (2021)
Living organisms are continuously under threat from a vast array of DNA-damaging agents, which impact genome DNA. DNA replication machinery stalls at damaged template DNA. The stalled replication fork is restarted via bypass replication by translesio
Autor:
Virginie Doyen, Jean-François Fils, Thanh Le Chi, Olivier Michel, Hoa Nhu Thi, Hiep Tran Thi Mong, Phuong Thi Ngoc Huynh, Carine Truyens, Francis Corazza, Carole Nagant
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252921 (2021)
PLoS ONE, Vol 16, Iss 6 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252921 (2021)
Background Like other helminths, hookworms (HW) induce a regulatory immune response able to modulate and dampen reactivity of the host to antigens. No data about the evolution of the immune response after treatment are available. We aim to phenotype
Autor:
Nathan A. Moore, Giulia Dowgier, Liliana Echavarría-Consuegra, Katherine A. Brown, Ian Brierley, Andrew E. Firth, Nicole Doyle, Charlotte Lefèvre, Sarah Keep, Georgia M. Cook, Nerea Irigoyen, Erica Bickerton, Stuart G. Siddell, Krzysztof Franaszek, Benjamin G. Hale, Idoia Busnadiego
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009644 (2021)
PLoS Pathogens, Vol 17, Iss 6, p e1009644 (2021)
Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load. We have used RNA sequencing and ribosom
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253218 (2021)
PLoS ONE, Vol 16, Iss 6, p e0253218 (2021)
Mounting evidence suggests that Lactobacillus species may not necessarily be the sine qua non of healthy cervicovaginal microbiota (CVM), especially among reproductive-age African women. A majority of African women have high-diversity non-Lactobacill